Toxicological Evaluations of a Popular Polyherbal Remedy-STC30 in Wistar Rats
Background: There is a rising trend in the use of herbal stem cell remedies among the populace due to the belief that such remedies have all-encompassing health benefits, and without side effects. However, there is little or no scientific data reported on their safety profile. This study addressed t...
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| Format: | Article |
| Language: | English |
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Arak University of Medical Sciences
2023-07-01
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| Series: | Iranian Journal of Toxicology |
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| Online Access: | https://ijt.arakmu.ac.ir/article-1-1229-en.html |
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| author | Earnest Oghenesuvwe Erhirhie Jennifer Nneoma Okafor Maureen Chinaecherem Nwafor Chukwuebuka Ozioma Ajaegbo heophine C. Akunne |
| author_facet | Earnest Oghenesuvwe Erhirhie Jennifer Nneoma Okafor Maureen Chinaecherem Nwafor Chukwuebuka Ozioma Ajaegbo heophine C. Akunne |
| author_sort | Earnest Oghenesuvwe Erhirhie |
| collection | DOAJ |
| description | Background: There is a rising trend in the use of herbal stem cell remedies among the populace due to the belief that such remedies have all-encompassing health benefits, and without side effects. However, there is little or no scientific data reported on their safety profile. This study addressed the toxicological effects of STC-30, one of the popular polyherbal stem cell remedies used in several countries of the world including Nigeria, Ghana, Australia, among others.
Methods: The acute toxicity test was carried out using Up and Down Procedure. For the sub-acute toxicity test, a total of 28 animals were used in four groups of seven each. The groups consisted of control, low dose (77.5 mg/kg), medium dose (155 mg/kg) and high dose (310 mg/kg). At the end of administration for 30-days, animals were sacrificed, and blood, kidneys and liver tissue samples were collected for hematological, biochemical and histopathological analyses.
Results: Acute toxicity test revealed no obvious toxicity or death at 5000 mg/kg. There was no significant alteration (P>0.05) in body weight gain, feed and water intakes, relative organ weights, urea, sodium, potassium, chloride, total protein and albumin, malondialdehyde (MDA), and white blood cells. However, significant reductions (P<0.05) were noted in creatinine and aspartate aminotransferase (AST), hematocrit, hemoglobin, red blood cell and mean corpuscular hemoglobin only at high dose (doubled therapeutic dose) compared to the controls. There were no abnormal changes in liver, kidney and heart histology.
Conclusion: Administration of STC-30 at the recommended dosage did not exert deleterious effects, but doubled therapeutic doses may be harmful to the red blood cells. |
| first_indexed | 2024-03-11T18:43:52Z |
| format | Article |
| id | doaj.art-8e2a107546b44dd48e797db65edbd0fa |
| institution | Directory Open Access Journal |
| issn | 2008-2967 2251-9459 |
| language | English |
| last_indexed | 2024-03-11T18:43:52Z |
| publishDate | 2023-07-01 |
| publisher | Arak University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Toxicology |
| spelling | doaj.art-8e2a107546b44dd48e797db65edbd0fa2023-10-12T06:44:03ZengArak University of Medical SciencesIranian Journal of Toxicology2008-29672251-94592023-07-011731910.61186/IJT.17.3.1Toxicological Evaluations of a Popular Polyherbal Remedy-STC30 in Wistar RatsEarnest Oghenesuvwe Erhirhie0Jennifer Nneoma Okafor1Maureen Chinaecherem Nwafor2Chukwuebuka Ozioma Ajaegbo3heophine C. Akunne4 Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Chukwuemeka Odumegwu Ojukwu University, Igbariam, NigeriaDepartment of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Chukwuemeka Odumegwu Ojukwu University, Igbariam, Nigeria Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Chukwuemeka Odumegwu Ojukwu University, Igbariam, NigeriaDepartment of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Chukwuemeka Odumegwu Ojukwu University, Igbariam, NigeriaDepartment of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, NigeriaBackground: There is a rising trend in the use of herbal stem cell remedies among the populace due to the belief that such remedies have all-encompassing health benefits, and without side effects. However, there is little or no scientific data reported on their safety profile. This study addressed the toxicological effects of STC-30, one of the popular polyherbal stem cell remedies used in several countries of the world including Nigeria, Ghana, Australia, among others. Methods: The acute toxicity test was carried out using Up and Down Procedure. For the sub-acute toxicity test, a total of 28 animals were used in four groups of seven each. The groups consisted of control, low dose (77.5 mg/kg), medium dose (155 mg/kg) and high dose (310 mg/kg). At the end of administration for 30-days, animals were sacrificed, and blood, kidneys and liver tissue samples were collected for hematological, biochemical and histopathological analyses. Results: Acute toxicity test revealed no obvious toxicity or death at 5000 mg/kg. There was no significant alteration (P>0.05) in body weight gain, feed and water intakes, relative organ weights, urea, sodium, potassium, chloride, total protein and albumin, malondialdehyde (MDA), and white blood cells. However, significant reductions (P<0.05) were noted in creatinine and aspartate aminotransferase (AST), hematocrit, hemoglobin, red blood cell and mean corpuscular hemoglobin only at high dose (doubled therapeutic dose) compared to the controls. There were no abnormal changes in liver, kidney and heart histology. Conclusion: Administration of STC-30 at the recommended dosage did not exert deleterious effects, but doubled therapeutic doses may be harmful to the red blood cells.https://ijt.arakmu.ac.ir/article-1-1229-en.htmlhematologyhistopathologykidneys and liver biomarkersstc30toxicity |
| spellingShingle | Earnest Oghenesuvwe Erhirhie Jennifer Nneoma Okafor Maureen Chinaecherem Nwafor Chukwuebuka Ozioma Ajaegbo heophine C. Akunne Toxicological Evaluations of a Popular Polyherbal Remedy-STC30 in Wistar Rats Iranian Journal of Toxicology hematology histopathology kidneys and liver biomarkers stc30 toxicity |
| title | Toxicological Evaluations of a Popular Polyherbal Remedy-STC30 in Wistar Rats |
| title_full | Toxicological Evaluations of a Popular Polyherbal Remedy-STC30 in Wistar Rats |
| title_fullStr | Toxicological Evaluations of a Popular Polyherbal Remedy-STC30 in Wistar Rats |
| title_full_unstemmed | Toxicological Evaluations of a Popular Polyherbal Remedy-STC30 in Wistar Rats |
| title_short | Toxicological Evaluations of a Popular Polyherbal Remedy-STC30 in Wistar Rats |
| title_sort | toxicological evaluations of a popular polyherbal remedy stc30 in wistar rats |
| topic | hematology histopathology kidneys and liver biomarkers stc30 toxicity |
| url | https://ijt.arakmu.ac.ir/article-1-1229-en.html |
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