Understanding the human ehrlichiosisis and standing out a causal agent: anaplasma phagocytophilum
Introduction: Anaplasma phagocytophilum is an obligatory intracytoplasmatic bacteriathat belong to Rickettsiales order and that has been recognized as a cause of humandisease. Most of symptomatic patients report exposure to ticks (vector) one or twoweeks before the beginning of the disease. They pre...
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| Format: | Article |
| Language: | Spanish |
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Universidad de Cartagena
2013-06-01
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| Series: | Revista Ciencias Biomédicas |
| Subjects: | |
| Online Access: | http://revistacienciasbiomedicas.com/index.php/revciencbiomed/article/view/265/210 |
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| author | Hernández-Ayazo Helí Marien-Clarete Said |
| author_facet | Hernández-Ayazo Helí Marien-Clarete Said |
| author_sort | Hernández-Ayazo Helí |
| collection | DOAJ |
| description | Introduction: Anaplasma phagocytophilum is an obligatory intracytoplasmatic bacteriathat belong to Rickettsiales order and that has been recognized as a cause of humandisease. Most of symptomatic patients report exposure to ticks (vector) one or twoweeks before the beginning of the disease. They present a febrile disease, however theclinical status extends since asymptomatic infection until fatal disease.Clinical case: Male patient with prolonged fever and with negative proofs in the searchof hepatitis, malaria, dengue, leptospirosis and typhoid disease. In the peripheralblood smear with Wright’s stain, there were found granulocytes with intracytoplasmatic vacuoles called morulae (microcolonies of Anaplasma phagocytophilum). Diagnosticimpression was Human Granulocytic Anaplasmosis (HGA). Treatment with tetracyclinewas done and good evolution was reported.Conclusion: HGA should be a disease to have present in patients with prolonged febrileprofile. A detailed clinical history with information about exposure to ticks should begotten. It is important an early diagnosis to establish the differences with other similarinfections and to apply promptly indicated antibiotic therapy. Rev.cienc.biomed.2013;4(1):165-169RESUMEN:Introducción: Anaplasma phagocytophilum es una bacteria intracitoplasmática obligadaque pertenece al orden Rickettsiales, reconocido como causante de enfermedaden humanos. Pacientes sintomáticos reportan exposición a las garrapatas (vector) unao dos semanas antes del inicio de la enfermedad. Presentan una enfermedad febril, noobstante el rango clínico se extiende desde infección asintomática hasta enfermedadfatal.Caso clínico: paciente masculino con cuadro febril prolongado. Pruebas negativas enla búsqueda de hepatitis, paludismo, dengue, leptospirosis y enfermedad tifoidea. Enel extendido de sangre periférica, con tinción de Wright se encontraron granulocitoscon vacuolas intracitoplasmáticas llamadas mórulas (microcolonias de Anaplasmaphagocytophilum). La impresión diagnóstica fue Anaplasmosis Humana Granulocítica(AHG). Se realizó tratamiento con tetraciclina presentándose buena evolución.Conclusión: la AHG debe ser una entidad a tener presente en los pacientes con cuadrofebril prolongado. Se debe obtener una historia clínica detallada buscando la exposicióna garrapatas. Es importante el diagnóstico temprano, establecer las diferencias conotras infecciones similares y aplicar prontamente la antibioticoterapia indicada. Rev.cienc.biomed. 2013;4(1):165-169 |
| first_indexed | 2024-12-22T00:56:15Z |
| format | Article |
| id | doaj.art-8e2ed6e41da64bc39d629252c7aabb51 |
| institution | Directory Open Access Journal |
| issn | 2215-7840 |
| language | Spanish |
| last_indexed | 2024-12-22T00:56:15Z |
| publishDate | 2013-06-01 |
| publisher | Universidad de Cartagena |
| record_format | Article |
| series | Revista Ciencias Biomédicas |
| spelling | doaj.art-8e2ed6e41da64bc39d629252c7aabb512022-12-21T18:44:18ZspaUniversidad de CartagenaRevista Ciencias Biomédicas2215-78402013-06-0141165169Understanding the human ehrlichiosisis and standing out a causal agent: anaplasma phagocytophilumHernández-Ayazo HelíMarien-Clarete SaidIntroduction: Anaplasma phagocytophilum is an obligatory intracytoplasmatic bacteriathat belong to Rickettsiales order and that has been recognized as a cause of humandisease. Most of symptomatic patients report exposure to ticks (vector) one or twoweeks before the beginning of the disease. They present a febrile disease, however theclinical status extends since asymptomatic infection until fatal disease.Clinical case: Male patient with prolonged fever and with negative proofs in the searchof hepatitis, malaria, dengue, leptospirosis and typhoid disease. In the peripheralblood smear with Wright’s stain, there were found granulocytes with intracytoplasmatic vacuoles called morulae (microcolonies of Anaplasma phagocytophilum). Diagnosticimpression was Human Granulocytic Anaplasmosis (HGA). Treatment with tetracyclinewas done and good evolution was reported.Conclusion: HGA should be a disease to have present in patients with prolonged febrileprofile. A detailed clinical history with information about exposure to ticks should begotten. It is important an early diagnosis to establish the differences with other similarinfections and to apply promptly indicated antibiotic therapy. Rev.cienc.biomed.2013;4(1):165-169RESUMEN:Introducción: Anaplasma phagocytophilum es una bacteria intracitoplasmática obligadaque pertenece al orden Rickettsiales, reconocido como causante de enfermedaden humanos. Pacientes sintomáticos reportan exposición a las garrapatas (vector) unao dos semanas antes del inicio de la enfermedad. Presentan una enfermedad febril, noobstante el rango clínico se extiende desde infección asintomática hasta enfermedadfatal.Caso clínico: paciente masculino con cuadro febril prolongado. Pruebas negativas enla búsqueda de hepatitis, paludismo, dengue, leptospirosis y enfermedad tifoidea. Enel extendido de sangre periférica, con tinción de Wright se encontraron granulocitoscon vacuolas intracitoplasmáticas llamadas mórulas (microcolonias de Anaplasmaphagocytophilum). La impresión diagnóstica fue Anaplasmosis Humana Granulocítica(AHG). Se realizó tratamiento con tetraciclina presentándose buena evolución.Conclusión: la AHG debe ser una entidad a tener presente en los pacientes con cuadrofebril prolongado. Se debe obtener una historia clínica detallada buscando la exposicióna garrapatas. Es importante el diagnóstico temprano, establecer las diferencias conotras infecciones similares y aplicar prontamente la antibioticoterapia indicada. Rev.cienc.biomed. 2013;4(1):165-169http://revistacienciasbiomedicas.com/index.php/revciencbiomed/article/view/265/210EhrlichiosesCommunicable DiseasesEmergingAnaplasma phagocytophilumIxodes. |
| spellingShingle | Hernández-Ayazo Helí Marien-Clarete Said Understanding the human ehrlichiosisis and standing out a causal agent: anaplasma phagocytophilum Revista Ciencias Biomédicas Ehrlichioses Communicable Diseases Emerging Anaplasma phagocytophilum Ixodes. |
| title | Understanding the human ehrlichiosisis and standing out a causal agent: anaplasma phagocytophilum |
| title_full | Understanding the human ehrlichiosisis and standing out a causal agent: anaplasma phagocytophilum |
| title_fullStr | Understanding the human ehrlichiosisis and standing out a causal agent: anaplasma phagocytophilum |
| title_full_unstemmed | Understanding the human ehrlichiosisis and standing out a causal agent: anaplasma phagocytophilum |
| title_short | Understanding the human ehrlichiosisis and standing out a causal agent: anaplasma phagocytophilum |
| title_sort | understanding the human ehrlichiosisis and standing out a causal agent anaplasma phagocytophilum |
| topic | Ehrlichioses Communicable Diseases Emerging Anaplasma phagocytophilum Ixodes. |
| url | http://revistacienciasbiomedicas.com/index.php/revciencbiomed/article/view/265/210 |
| work_keys_str_mv | AT hernandezayazoheli understandingthehumanehrlichiosisisandstandingoutacausalagentanaplasmaphagocytophilum AT marienclaretesaid understandingthehumanehrlichiosisisandstandingoutacausalagentanaplasmaphagocytophilum |