Diagnostic Performance of Extrahepatic Protein Induced by Vitamin K Absence in the Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Background and Objectives: the early diagnosis of hepatocellular carcinoma (HCC) benefits from the use of alpha-fetoprotein (AFP) together with imaging diagnosis using abdominal ultrasonography, CT, and MRI, leading to improved early detection of HCC. A lot of progress has been made in the field, bu...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/5/816 |
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| author | Mirela Georgiana Perne Adela-Viviana Sitar-Tăut Teodora Gabriela Alexescu Lorena Ciumărnean Mircea-Vasile Milaciu Sorina-Cezara Coste Calin-Vasile Vlad Angela Cozma Dan-Andrei Sitar-Tăut Olga Hilda Orăşan Alexandra Crăciun |
| author_facet | Mirela Georgiana Perne Adela-Viviana Sitar-Tăut Teodora Gabriela Alexescu Lorena Ciumărnean Mircea-Vasile Milaciu Sorina-Cezara Coste Calin-Vasile Vlad Angela Cozma Dan-Andrei Sitar-Tăut Olga Hilda Orăşan Alexandra Crăciun |
| author_sort | Mirela Georgiana Perne |
| collection | DOAJ |
| description | Background and Objectives: the early diagnosis of hepatocellular carcinoma (HCC) benefits from the use of alpha-fetoprotein (AFP) together with imaging diagnosis using abdominal ultrasonography, CT, and MRI, leading to improved early detection of HCC. A lot of progress has been made in the field, but some cases are missed or late diagnosed in advanced stages of the disease. Therefore, new tools (serum markers, imagistic technics) are continually being reconsidered. Serum alpha-fetoprotein (AFP), protein induced by vitamin K absence or antagonist II (PIVKA II) diagnostic accuracy for HCC (global and early disease) has been investigated (in a separate or cumulative way). The purpose of the present study was to determine the performance of PIVKA II compared to AFP. Materials and Methods: systematic research was conducted in PubMed, Web of Science, Embase, Medline and the Cochrane Central Register of Controlled Trials, taking into consideration articles published between 2018 and 2022. Results: a total number of 37 studies (5037 patients with HCC vs. 8199 patients—control group) have been included in the meta-analysis. PIVKA II presented a better diagnostic accuracy in HCC diagnostic vs. alpha-fetoprotein (global PIVKA II AUROC 0.851 vs. AFP AUROC 0.808, respectively, 0.790 vs. 0.740 in early HCC cases). The conclusion from a clinical point of view, concomitant use of PIVKA II and AFP can bring useful information, added to that brought by ultrasound examination. |
| first_indexed | 2024-03-11T07:28:53Z |
| format | Article |
| id | doaj.art-8e2fe6cf2c53421398786bddbf7bdb20 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T07:28:53Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-8e2fe6cf2c53421398786bddbf7bdb202023-11-17T07:28:36ZengMDPI AGDiagnostics2075-44182023-02-0113581610.3390/diagnostics13050816Diagnostic Performance of Extrahepatic Protein Induced by Vitamin K Absence in the Hepatocellular Carcinoma: A Systematic Review and Meta-AnalysisMirela Georgiana Perne0Adela-Viviana Sitar-Tăut1Teodora Gabriela Alexescu2Lorena Ciumărnean3Mircea-Vasile Milaciu4Sorina-Cezara Coste5Calin-Vasile Vlad6Angela Cozma7Dan-Andrei Sitar-Tăut8Olga Hilda Orăşan9Alexandra Crăciun104th Medical Clinic, Internal Medicine Department, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy Victor Babes Street, 400347 Cluj-Napoca, Romania4th Medical Clinic, Internal Medicine Department, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy Victor Babes Street, 400347 Cluj-Napoca, Romania4th Medical Clinic, Internal Medicine Department, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy Victor Babes Street, 400347 Cluj-Napoca, Romania4th Medical Clinic, Internal Medicine Department, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy Victor Babes Street, 400347 Cluj-Napoca, Romania4th Medical Clinic, Internal Medicine Department, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy Victor Babes Street, 400347 Cluj-Napoca, Romania4th Medical Clinic, Internal Medicine Department, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy Victor Babes Street, 400347 Cluj-Napoca, Romania4th Medical Clinic, Internal Medicine Department, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy Victor Babes Street, 400347 Cluj-Napoca, Romania4th Medical Clinic, Internal Medicine Department, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy Victor Babes Street, 400347 Cluj-Napoca, RomaniaDepartment of Business Information Systems, Faculty of Economics and Business Administration, Babeş-Bolyai University, 58–60 Theodor Mihaly Street, 400591 Cluj-Napoca, Romania4th Medical Clinic, Internal Medicine Department, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy Victor Babes Street, 400347 Cluj-Napoca, RomaniaDiscipline of Medical Biochemistry, 3rd Department—Molecular Sciences, Faculty of Medicine, “Iuliu Haţieganu” University of Medicine and Pharmacy, Victor Babes Street, 400347 Cluj-Napoca, RomaniaBackground and Objectives: the early diagnosis of hepatocellular carcinoma (HCC) benefits from the use of alpha-fetoprotein (AFP) together with imaging diagnosis using abdominal ultrasonography, CT, and MRI, leading to improved early detection of HCC. A lot of progress has been made in the field, but some cases are missed or late diagnosed in advanced stages of the disease. Therefore, new tools (serum markers, imagistic technics) are continually being reconsidered. Serum alpha-fetoprotein (AFP), protein induced by vitamin K absence or antagonist II (PIVKA II) diagnostic accuracy for HCC (global and early disease) has been investigated (in a separate or cumulative way). The purpose of the present study was to determine the performance of PIVKA II compared to AFP. Materials and Methods: systematic research was conducted in PubMed, Web of Science, Embase, Medline and the Cochrane Central Register of Controlled Trials, taking into consideration articles published between 2018 and 2022. Results: a total number of 37 studies (5037 patients with HCC vs. 8199 patients—control group) have been included in the meta-analysis. PIVKA II presented a better diagnostic accuracy in HCC diagnostic vs. alpha-fetoprotein (global PIVKA II AUROC 0.851 vs. AFP AUROC 0.808, respectively, 0.790 vs. 0.740 in early HCC cases). The conclusion from a clinical point of view, concomitant use of PIVKA II and AFP can bring useful information, added to that brought by ultrasound examination.https://www.mdpi.com/2075-4418/13/5/816hepatocellular carcinomaPIVKA IIalpha-fetoproteindiagnosis |
| spellingShingle | Mirela Georgiana Perne Adela-Viviana Sitar-Tăut Teodora Gabriela Alexescu Lorena Ciumărnean Mircea-Vasile Milaciu Sorina-Cezara Coste Calin-Vasile Vlad Angela Cozma Dan-Andrei Sitar-Tăut Olga Hilda Orăşan Alexandra Crăciun Diagnostic Performance of Extrahepatic Protein Induced by Vitamin K Absence in the Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis Diagnostics hepatocellular carcinoma PIVKA II alpha-fetoprotein diagnosis |
| title | Diagnostic Performance of Extrahepatic Protein Induced by Vitamin K Absence in the Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis |
| title_full | Diagnostic Performance of Extrahepatic Protein Induced by Vitamin K Absence in the Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis |
| title_fullStr | Diagnostic Performance of Extrahepatic Protein Induced by Vitamin K Absence in the Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Diagnostic Performance of Extrahepatic Protein Induced by Vitamin K Absence in the Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis |
| title_short | Diagnostic Performance of Extrahepatic Protein Induced by Vitamin K Absence in the Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis |
| title_sort | diagnostic performance of extrahepatic protein induced by vitamin k absence in the hepatocellular carcinoma a systematic review and meta analysis |
| topic | hepatocellular carcinoma PIVKA II alpha-fetoprotein diagnosis |
| url | https://www.mdpi.com/2075-4418/13/5/816 |
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