The clinical value of carcinoembryonic antigen for tumor metastasis assessment in lung cancer
Background Carcinoembryonic antigen (CEA) as a diagnostic or prognostic marker has been widely studied in patients with lung cancer. However, the relationship between serum CEA and tumor metastasis in lung cancer remains controversial. This study aimed to investigate the ability of serum CEA to asse...
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PeerJ Inc.
2019-08-01
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| Online Access: | https://peerj.com/articles/7433.pdf |
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| author | Jiasi Wang Yanpeng Chu Jie Li Tingjie Wang Liangli Sun Pingfei Wang Xiangdong Fang Fanwei Zeng Junfeng Wang Fanxin Zeng |
| author_facet | Jiasi Wang Yanpeng Chu Jie Li Tingjie Wang Liangli Sun Pingfei Wang Xiangdong Fang Fanwei Zeng Junfeng Wang Fanxin Zeng |
| author_sort | Jiasi Wang |
| collection | DOAJ |
| description | Background Carcinoembryonic antigen (CEA) as a diagnostic or prognostic marker has been widely studied in patients with lung cancer. However, the relationship between serum CEA and tumor metastasis in lung cancer remains controversial. This study aimed to investigate the ability of serum CEA to assess tumor metastasis in lung cancer patients. Methods We performed a retrospective analysis of 238 patients diagnosed with lung cancer from January to December 2016 at pneumology department of Dazhou Central Hospital (Dazhou, China). Serum CEA levels were quantified in each patient at the time of diagnosis of lung cancer. Metastasis was confirmed by computed tomography (CT), and/or positron emission tomography (PET) and/or surgery or other necessary detecting methods. Results Of the 213 patients eligible for final analysis, 128 were diagnosed with metastasis and 85 were diagnosed without metastasis. Compared to non-metastatic patients, the serum CEA was markedly higher in patients with metastasis (p < 0.001), and the area under the curve (AUC) was 0.724 (95% CI [0.654–0.793]). Subsequent analyses regarding the number and location of tumor metastases showed that CEA also had clinical value for multiple metastases versus single metastasis (AUC = 0.780, 95% CI [0.699–0.862]) and distant metastasis versus non-distant metastasis (AUC = 0.815, 95% CI [0.733–0.897]). In addition, we found that tumor size, histology diagnosis, age and gender had no impact on the assessment performance of CEA. Conclusion Our study suggested the serum CEA as a valuable marker for tumor metastases assessment in newly diagnosed lung cancer patients, which could have some implications in clinical application. |
| first_indexed | 2024-03-09T06:41:27Z |
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| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:41:27Z |
| publishDate | 2019-08-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj.art-8e3006bdbd814e609f0c6aa6f5026e4f2023-12-03T10:50:51ZengPeerJ Inc.PeerJ2167-83592019-08-017e743310.7717/peerj.7433The clinical value of carcinoembryonic antigen for tumor metastasis assessment in lung cancerJiasi Wang0Yanpeng Chu1Jie Li2Tingjie Wang3Liangli Sun4Pingfei Wang5Xiangdong Fang6Fanwei Zeng7Junfeng Wang8Fanxin Zeng9Department of Clinical Laboratory, Dazhou Central Hospital, Dazhou, Sichuan, ChinaDepartment of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan, ChinaDepartment of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan, ChinaDepartment of Clinical Laboratory, Dazhou Central Hospital, Dazhou, Sichuan, ChinaDepartment of Clinical Laboratory, Dazhou Central Hospital, Dazhou, Sichuan, ChinaDepartment of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan, ChinaDepartment of Oncology, Dazhou Central Hospital, Dazhou, Sichuan, ChinaDepartment of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan, ChinaDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The NetherlandsDepartment of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan, ChinaBackground Carcinoembryonic antigen (CEA) as a diagnostic or prognostic marker has been widely studied in patients with lung cancer. However, the relationship between serum CEA and tumor metastasis in lung cancer remains controversial. This study aimed to investigate the ability of serum CEA to assess tumor metastasis in lung cancer patients. Methods We performed a retrospective analysis of 238 patients diagnosed with lung cancer from January to December 2016 at pneumology department of Dazhou Central Hospital (Dazhou, China). Serum CEA levels were quantified in each patient at the time of diagnosis of lung cancer. Metastasis was confirmed by computed tomography (CT), and/or positron emission tomography (PET) and/or surgery or other necessary detecting methods. Results Of the 213 patients eligible for final analysis, 128 were diagnosed with metastasis and 85 were diagnosed without metastasis. Compared to non-metastatic patients, the serum CEA was markedly higher in patients with metastasis (p < 0.001), and the area under the curve (AUC) was 0.724 (95% CI [0.654–0.793]). Subsequent analyses regarding the number and location of tumor metastases showed that CEA also had clinical value for multiple metastases versus single metastasis (AUC = 0.780, 95% CI [0.699–0.862]) and distant metastasis versus non-distant metastasis (AUC = 0.815, 95% CI [0.733–0.897]). In addition, we found that tumor size, histology diagnosis, age and gender had no impact on the assessment performance of CEA. Conclusion Our study suggested the serum CEA as a valuable marker for tumor metastases assessment in newly diagnosed lung cancer patients, which could have some implications in clinical application.https://peerj.com/articles/7433.pdfSerum carcinoembryonic antigenLung cancerTumor metastasisPerformance of assessmentReceiver operating characteristic |
| spellingShingle | Jiasi Wang Yanpeng Chu Jie Li Tingjie Wang Liangli Sun Pingfei Wang Xiangdong Fang Fanwei Zeng Junfeng Wang Fanxin Zeng The clinical value of carcinoembryonic antigen for tumor metastasis assessment in lung cancer PeerJ Serum carcinoembryonic antigen Lung cancer Tumor metastasis Performance of assessment Receiver operating characteristic |
| title | The clinical value of carcinoembryonic antigen for tumor metastasis assessment in lung cancer |
| title_full | The clinical value of carcinoembryonic antigen for tumor metastasis assessment in lung cancer |
| title_fullStr | The clinical value of carcinoembryonic antigen for tumor metastasis assessment in lung cancer |
| title_full_unstemmed | The clinical value of carcinoembryonic antigen for tumor metastasis assessment in lung cancer |
| title_short | The clinical value of carcinoembryonic antigen for tumor metastasis assessment in lung cancer |
| title_sort | clinical value of carcinoembryonic antigen for tumor metastasis assessment in lung cancer |
| topic | Serum carcinoembryonic antigen Lung cancer Tumor metastasis Performance of assessment Receiver operating characteristic |
| url | https://peerj.com/articles/7433.pdf |
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