Donor Age and Non-Relapse Mortality: Study of Their Association after HLA-Matched Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome
The purpose of this retrospective study was to study the correlation between donor age (DA) and non-relapse mortality (NRM) and relapse incidence (RI) among patients treated with allogeneic hematopoietic cell transplantation (aHCT) for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) i...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/29/8/470 |
| _version_ | 1827628628985249792 |
|---|---|
| author | Yasmine Kadri Michelle Phan Nadia Bambace Léa Bernard Sandra Cohen Jean-Sébastien Delisle Thomas Kiss Sylvie Lachance Denis-Claude Roy Guy Sauvageau Olivier Veilleux Jean Roy Imran Ahmad |
| author_facet | Yasmine Kadri Michelle Phan Nadia Bambace Léa Bernard Sandra Cohen Jean-Sébastien Delisle Thomas Kiss Sylvie Lachance Denis-Claude Roy Guy Sauvageau Olivier Veilleux Jean Roy Imran Ahmad |
| author_sort | Yasmine Kadri |
| collection | DOAJ |
| description | The purpose of this retrospective study was to study the correlation between donor age (DA) and non-relapse mortality (NRM) and relapse incidence (RI) among patients treated with allogeneic hematopoietic cell transplantation (aHCT) for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) in a single Canadian center. Data from 125 consecutive patients transplanted with a matched related or unrelated donor between 2015 and 2020 were analyzed using multivariable models. After a median follow-up of 2.8 years, the cumulative incidences of NRM and relapse were 19% and 35% at 5 years. Despite being independently associated with NRM and relapse-free survival (RFS), DA was not associated with RI. The independent determinants of NRM in addition to DA were patient age and hematopoietic cell transplantation comorbidity index (HCT-CI), independently of donor kinship. The effect of DA on NRM was found to be significantly increased over the age of 50 years. DA was not associated with incidence of acute graft-versus-host disease (aGVHD) but showed an association with the occurrence of chronic GVHD (cGVHD). In conclusion, younger donors should be favored to limit NRM and increase RFS in HLA-matched aHCT. The etiological mechanisms behind the association of DA with higher NRM remain to be elucidated. |
| first_indexed | 2024-03-09T13:36:09Z |
| format | Article |
| id | doaj.art-8e30afbb32ae4e7d91ee3b004756ff18 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T13:36:09Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-8e30afbb32ae4e7d91ee3b004756ff182023-11-30T21:11:51ZengMDPI AGCurrent Oncology1198-00521718-77292022-08-012985955596210.3390/curroncol29080470Donor Age and Non-Relapse Mortality: Study of Their Association after HLA-Matched Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic SyndromeYasmine Kadri0Michelle Phan1Nadia Bambace2Léa Bernard3Sandra Cohen4Jean-Sébastien Delisle5Thomas Kiss6Sylvie Lachance7Denis-Claude Roy8Guy Sauvageau9Olivier Veilleux10Jean Roy11Imran Ahmad12Département de Médecine, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, CanadaDépartement de Pharmacologie & Physiologie, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, CanadaDépartement de Médecine, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, CanadaDépartement de Médecine, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, CanadaDépartement de Médecine, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, CanadaDépartement de Médecine, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, CanadaDépartement de Médecine, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, CanadaDépartement de Médecine, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, CanadaDépartement de Médecine, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, CanadaDépartement de Médecine, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, CanadaDépartement de Médecine, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, CanadaDépartement de Médecine, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, CanadaDépartement de Médecine, Faculté de Médecine, Université de Montréal, Montreal, QC H3T 1J4, CanadaThe purpose of this retrospective study was to study the correlation between donor age (DA) and non-relapse mortality (NRM) and relapse incidence (RI) among patients treated with allogeneic hematopoietic cell transplantation (aHCT) for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) in a single Canadian center. Data from 125 consecutive patients transplanted with a matched related or unrelated donor between 2015 and 2020 were analyzed using multivariable models. After a median follow-up of 2.8 years, the cumulative incidences of NRM and relapse were 19% and 35% at 5 years. Despite being independently associated with NRM and relapse-free survival (RFS), DA was not associated with RI. The independent determinants of NRM in addition to DA were patient age and hematopoietic cell transplantation comorbidity index (HCT-CI), independently of donor kinship. The effect of DA on NRM was found to be significantly increased over the age of 50 years. DA was not associated with incidence of acute graft-versus-host disease (aGVHD) but showed an association with the occurrence of chronic GVHD (cGVHD). In conclusion, younger donors should be favored to limit NRM and increase RFS in HLA-matched aHCT. The etiological mechanisms behind the association of DA with higher NRM remain to be elucidated.https://www.mdpi.com/1718-7729/29/8/470acute myeloid leukemiamyelodysplastic syndromeallogenic hematopoietic cell transplantationdonor agenon-relapse mortalitygraft-versus-host disease |
| spellingShingle | Yasmine Kadri Michelle Phan Nadia Bambace Léa Bernard Sandra Cohen Jean-Sébastien Delisle Thomas Kiss Sylvie Lachance Denis-Claude Roy Guy Sauvageau Olivier Veilleux Jean Roy Imran Ahmad Donor Age and Non-Relapse Mortality: Study of Their Association after HLA-Matched Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome Current Oncology acute myeloid leukemia myelodysplastic syndrome allogenic hematopoietic cell transplantation donor age non-relapse mortality graft-versus-host disease |
| title | Donor Age and Non-Relapse Mortality: Study of Their Association after HLA-Matched Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome |
| title_full | Donor Age and Non-Relapse Mortality: Study of Their Association after HLA-Matched Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome |
| title_fullStr | Donor Age and Non-Relapse Mortality: Study of Their Association after HLA-Matched Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome |
| title_full_unstemmed | Donor Age and Non-Relapse Mortality: Study of Their Association after HLA-Matched Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome |
| title_short | Donor Age and Non-Relapse Mortality: Study of Their Association after HLA-Matched Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome |
| title_sort | donor age and non relapse mortality study of their association after hla matched allogeneic hematopoietic cell transplantation for acute myeloid leukemia and myelodysplastic syndrome |
| topic | acute myeloid leukemia myelodysplastic syndrome allogenic hematopoietic cell transplantation donor age non-relapse mortality graft-versus-host disease |
| url | https://www.mdpi.com/1718-7729/29/8/470 |
| work_keys_str_mv | AT yasminekadri donorageandnonrelapsemortalitystudyoftheirassociationafterhlamatchedallogeneichematopoieticcelltransplantationforacutemyeloidleukemiaandmyelodysplasticsyndrome AT michellephan donorageandnonrelapsemortalitystudyoftheirassociationafterhlamatchedallogeneichematopoieticcelltransplantationforacutemyeloidleukemiaandmyelodysplasticsyndrome AT nadiabambace donorageandnonrelapsemortalitystudyoftheirassociationafterhlamatchedallogeneichematopoieticcelltransplantationforacutemyeloidleukemiaandmyelodysplasticsyndrome AT leabernard donorageandnonrelapsemortalitystudyoftheirassociationafterhlamatchedallogeneichematopoieticcelltransplantationforacutemyeloidleukemiaandmyelodysplasticsyndrome AT sandracohen donorageandnonrelapsemortalitystudyoftheirassociationafterhlamatchedallogeneichematopoieticcelltransplantationforacutemyeloidleukemiaandmyelodysplasticsyndrome AT jeansebastiendelisle donorageandnonrelapsemortalitystudyoftheirassociationafterhlamatchedallogeneichematopoieticcelltransplantationforacutemyeloidleukemiaandmyelodysplasticsyndrome AT thomaskiss donorageandnonrelapsemortalitystudyoftheirassociationafterhlamatchedallogeneichematopoieticcelltransplantationforacutemyeloidleukemiaandmyelodysplasticsyndrome AT sylvielachance donorageandnonrelapsemortalitystudyoftheirassociationafterhlamatchedallogeneichematopoieticcelltransplantationforacutemyeloidleukemiaandmyelodysplasticsyndrome AT denisclauderoy donorageandnonrelapsemortalitystudyoftheirassociationafterhlamatchedallogeneichematopoieticcelltransplantationforacutemyeloidleukemiaandmyelodysplasticsyndrome AT guysauvageau donorageandnonrelapsemortalitystudyoftheirassociationafterhlamatchedallogeneichematopoieticcelltransplantationforacutemyeloidleukemiaandmyelodysplasticsyndrome AT olivierveilleux donorageandnonrelapsemortalitystudyoftheirassociationafterhlamatchedallogeneichematopoieticcelltransplantationforacutemyeloidleukemiaandmyelodysplasticsyndrome AT jeanroy donorageandnonrelapsemortalitystudyoftheirassociationafterhlamatchedallogeneichematopoieticcelltransplantationforacutemyeloidleukemiaandmyelodysplasticsyndrome AT imranahmad donorageandnonrelapsemortalitystudyoftheirassociationafterhlamatchedallogeneichematopoieticcelltransplantationforacutemyeloidleukemiaandmyelodysplasticsyndrome |