Vitamin insufficiency after surgery for oesophagogastric neoplasms: a study protocol for a prospective intervention study
Introduction Oesophageal cancer (EC) and gastric cancer (GC) are among the top 10 cancers worldwide. Both diseases impact the nutritional status of patients and their Quality of Life (QoL). Preoperative malnutrition is reported in 42%–80%. However, studies investigating postoperative nutritional sta...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/7/e067981.full |
| _version_ | 1797745687547346944 |
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| author | Ariadne L van der Velden Thomas A Vermeer Evert-Jan G Boerma Eric HJ Belgers Jan HMB Stoot Mathie PG Leers Meindert N Sosef Guy HEJ Vijgen |
| author_facet | Ariadne L van der Velden Thomas A Vermeer Evert-Jan G Boerma Eric HJ Belgers Jan HMB Stoot Mathie PG Leers Meindert N Sosef Guy HEJ Vijgen |
| author_sort | Ariadne L van der Velden |
| collection | DOAJ |
| description | Introduction Oesophageal cancer (EC) and gastric cancer (GC) are among the top 10 cancers worldwide. Both diseases impact the nutritional status of patients and their Quality of Life (QoL). Preoperative malnutrition is reported in 42%–80%. However, studies investigating postoperative nutritional status are limited, and postoperative identification and treatment of micronutrient and macronutrient deficiencies are currently lacking in (inter-)national guidelines. The aim of this study is to identify and target micronutrient deficiencies after surgery for oesophagogastric neoplasms.Methods This is a single-centre prospective intervention trial performed in Zuyderland Medical Centre. 248 patients who underwent oesophagectomy (n=124) or (sub)total gastrectomy (n=124) from 2011 until 2022 will be included. Both groups will receive Calcium Soft Chew D3 and a multivitamin supplement (MVS) specifically developed according to the type of operation patients underwent; the oesophagectomy group will receive Multi-E and the gastrectomy group will receive Multi-G. The MVSs will be taken once daily and Calcium Soft Chew D3 two times per day. Supplementation will start after baseline measurements. At baseline (T0), blood withdrawal for micronutrient analysis and faecal elastase-1 analysis for exocrine pancreatic insufficiency (EPI) will be performed. Additionally, patients will receive questionnaires regarding QoL and dietary behaviour. After 180 days of supplementation (T1), baseline measurements will be repeated, and the supplement tolerance questionnaire will be completed. Measurements will also be conducted after 360 days (T2) and after 720 days (T3) of supplementation. The main study parameter is micronutrient deficiency (yes/no) for all measurements. Secondary parameters include occurrence of EPI (n, %), diarrhoea (n, %), steatorrhoea (n, %) or bloating (n, %), time between surgery and start of supplementation (mean in months), and QoL at all time points.Ethics and dissemination The study was approved by the Zuyderland Medical Centre Ethics Committee, Heerlen, the Netherlands. The findings will be disseminated through scientific congresses and in peer-reviewed journals.Trial registration number NCT05281380. |
| first_indexed | 2024-03-12T15:27:42Z |
| format | Article |
| id | doaj.art-8e317ed035d34ddb8d7c8326c6168c18 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-12T15:27:42Z |
| publishDate | 2023-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-8e317ed035d34ddb8d7c8326c6168c182023-08-10T12:05:07ZengBMJ Publishing GroupBMJ Open2044-60552023-07-0113710.1136/bmjopen-2022-067981Vitamin insufficiency after surgery for oesophagogastric neoplasms: a study protocol for a prospective intervention studyAriadne L van der Velden0Thomas A Vermeer1Evert-Jan G Boerma2Eric HJ Belgers3Jan HMB Stoot4Mathie PG Leers5Meindert N Sosef6Guy HEJ Vijgen71 Department of Surgery, Zuyderland Medical Centre, Heerlen, The Netherlands1 Department of Surgery, Zuyderland Medical Centre, Heerlen, The Netherlands1 Department of Surgery, Zuyderland Medical Centre, Heerlen, The Netherlands1 Department of Surgery, Zuyderland Medical Centre, Heerlen, The Netherlands1 Department of Surgery, Zuyderland Medical Centre, Heerlen, The Netherlands2 Clinical Chemistry & Hematology, Zuyderland Medical Centre, Heerlen, The Netherlands1 Department of Surgery, Zuyderland Medical Centre, Heerlen, The Netherlands1 Department of Surgery, Zuyderland Medical Centre, Heerlen, The NetherlandsIntroduction Oesophageal cancer (EC) and gastric cancer (GC) are among the top 10 cancers worldwide. Both diseases impact the nutritional status of patients and their Quality of Life (QoL). Preoperative malnutrition is reported in 42%–80%. However, studies investigating postoperative nutritional status are limited, and postoperative identification and treatment of micronutrient and macronutrient deficiencies are currently lacking in (inter-)national guidelines. The aim of this study is to identify and target micronutrient deficiencies after surgery for oesophagogastric neoplasms.Methods This is a single-centre prospective intervention trial performed in Zuyderland Medical Centre. 248 patients who underwent oesophagectomy (n=124) or (sub)total gastrectomy (n=124) from 2011 until 2022 will be included. Both groups will receive Calcium Soft Chew D3 and a multivitamin supplement (MVS) specifically developed according to the type of operation patients underwent; the oesophagectomy group will receive Multi-E and the gastrectomy group will receive Multi-G. The MVSs will be taken once daily and Calcium Soft Chew D3 two times per day. Supplementation will start after baseline measurements. At baseline (T0), blood withdrawal for micronutrient analysis and faecal elastase-1 analysis for exocrine pancreatic insufficiency (EPI) will be performed. Additionally, patients will receive questionnaires regarding QoL and dietary behaviour. After 180 days of supplementation (T1), baseline measurements will be repeated, and the supplement tolerance questionnaire will be completed. Measurements will also be conducted after 360 days (T2) and after 720 days (T3) of supplementation. The main study parameter is micronutrient deficiency (yes/no) for all measurements. Secondary parameters include occurrence of EPI (n, %), diarrhoea (n, %), steatorrhoea (n, %) or bloating (n, %), time between surgery and start of supplementation (mean in months), and QoL at all time points.Ethics and dissemination The study was approved by the Zuyderland Medical Centre Ethics Committee, Heerlen, the Netherlands. The findings will be disseminated through scientific congresses and in peer-reviewed journals.Trial registration number NCT05281380.https://bmjopen.bmj.com/content/13/7/e067981.full |
| spellingShingle | Ariadne L van der Velden Thomas A Vermeer Evert-Jan G Boerma Eric HJ Belgers Jan HMB Stoot Mathie PG Leers Meindert N Sosef Guy HEJ Vijgen Vitamin insufficiency after surgery for oesophagogastric neoplasms: a study protocol for a prospective intervention study BMJ Open |
| title | Vitamin insufficiency after surgery for oesophagogastric neoplasms: a study protocol for a prospective intervention study |
| title_full | Vitamin insufficiency after surgery for oesophagogastric neoplasms: a study protocol for a prospective intervention study |
| title_fullStr | Vitamin insufficiency after surgery for oesophagogastric neoplasms: a study protocol for a prospective intervention study |
| title_full_unstemmed | Vitamin insufficiency after surgery for oesophagogastric neoplasms: a study protocol for a prospective intervention study |
| title_short | Vitamin insufficiency after surgery for oesophagogastric neoplasms: a study protocol for a prospective intervention study |
| title_sort | vitamin insufficiency after surgery for oesophagogastric neoplasms a study protocol for a prospective intervention study |
| url | https://bmjopen.bmj.com/content/13/7/e067981.full |
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