Astrovirus-induced epithelial-mesenchymal transition via activated TGF-β increases viral replication.

Astrovirus-induced epithelial-mesenchymal transition via activated TGF-β increases viral replication.

Human astroviruses (HAstV), positive sense single-stranded RNA viruses, are one of the leading causes of diarrhea worldwide. Despite their high prevalence, the cellular mechanisms of astrovirus pathogenesis remain ill-defined. Previous studies showed HAstV increased epithelial barrier permeability b...

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Bibliographic Details
Main Authors: Virginia Hargest, Theresa Bub, Geoffrey Neale, Stacey Schultz-Cherry
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009716

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