The Associations of Two Novel Inflammation Biomarkers, SIRI and SII, with Mortality Risk in Patients with Chronic Heart Failure
Di Zhu,1,2,* Chi Wang,1,* You Zhou,3 Hebin Che,1 Ruiqing Wang,1,2 Liting Cheng,3 Chongyou Rao,1,2 Qin Zhong,1 Zongren Li,1 Yongjie Duan,1,2 Kunlun He1 1Medical Big Data Research Center, Medical Innovation Research Department of PLA General Hospital, Beijing, 100853, People’s Republic...
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Dove Medical Press
2024-02-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/the-associations-of-two-novel-inflammation-biomarkers-siri-and-sii-wit-peer-reviewed-fulltext-article-JIR |
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| author | Zhu D Wang C Zhou Y Che H Wang R Cheng L Rao C Zhong Q Li Z Duan Y He K |
| author_facet | Zhu D Wang C Zhou Y Che H Wang R Cheng L Rao C Zhong Q Li Z Duan Y He K |
| author_sort | Zhu D |
| collection | DOAJ |
| description | Di Zhu,1,2,* Chi Wang,1,* You Zhou,3 Hebin Che,1 Ruiqing Wang,1,2 Liting Cheng,3 Chongyou Rao,1,2 Qin Zhong,1 Zongren Li,1 Yongjie Duan,1,2 Kunlun He1 1Medical Big Data Research Center, Medical Innovation Research Department of PLA General Hospital, Beijing, 100853, People’s Republic of China; 2Graduate School of PLA General Hospital, Beijing, 100853, People’s Republic of China; 3School of Medicine, Nankai University, Tianjin, 300071, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kunlun He, Medical Big Data Research Center, Medical Innovation Research Department of PLA General Hospital, 28 Fuxing Road, Beijing, 100853, People’s Republic of China, Tel +86-10-66939107, Email kunlunhe@plagh.orgBackground: The associations of two novel inflammation biomarkers, systemic inflammation response index (SIRI) and systemic immune inflammation index (SII), with mortality risk in patients with chronic heart failure (CHF) are not well-characterized.Methods: This retrospective cohort study included patients with CHF in two medical centers of Chinese People’s Liberation Army General Hospital, Beijing, China. The outcomes of this study included in-hospital mortality and long-term mortality. Associations of SIRI and SII with mortality were assessed using multivariable regressions and receiver operating characteristic (ROC) analyses.Results: A total of 6232 patients with CHF were included in the present study. We documented 97 cases of in-hospital mortality and 1738 cases of long-term mortality during an average 5.01-year follow-up. Compared with patients in the lowest quartile of SIRI, those in the highest quartile exhibited 134% higher risk of in-hospital mortality (adjusted odds ratio, 2.34; 95% confidence interval [CI], 1.16– 4.72) and 45% higher risk of long-term mortality (adjusted hazard ratio, 1.45; 95% CI, 1.25– 1.67). Compared with patients in the lowest quartile of SII, those in the highest quartile exhibited 27% higher risk of long-term mortality (adjusted hazard ratio, 1.27; 95% CI, 1.11– 1.46). In ROC analyses, SIRI showed better prognostic discrimination than C-reactive protein (area under the curve: 69.39 vs 60.91, P = 0.01, for in-hospital mortality; 61.82 vs 58.67, P = 0.03, for 3-year mortality), whereas SII showed similar prognostic value with C-reactive protein.Conclusion: SIRI and SII were significantly associated with mortality risk in patients with CHF. SIRI may provide better prognostic discrimination than C-reactive protein.Keywords: systemic inflammation, systemic immune inflammation index, systemic inflammation response index, chronic heart failure, mortality risk |
| first_indexed | 2024-03-07T21:45:33Z |
| format | Article |
| id | doaj.art-8e33532fb2144427a4cf3ec33bae697e |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-03-07T21:45:33Z |
| publishDate | 2024-02-01 |
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| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-8e33532fb2144427a4cf3ec33bae697e2024-02-25T18:46:48ZengDove Medical PressJournal of Inflammation Research1178-70312024-02-01Volume 171255126490681The Associations of Two Novel Inflammation Biomarkers, SIRI and SII, with Mortality Risk in Patients with Chronic Heart FailureZhu DWang CZhou YChe HWang RCheng LRao CZhong QLi ZDuan YHe KDi Zhu,1,2,* Chi Wang,1,* You Zhou,3 Hebin Che,1 Ruiqing Wang,1,2 Liting Cheng,3 Chongyou Rao,1,2 Qin Zhong,1 Zongren Li,1 Yongjie Duan,1,2 Kunlun He1 1Medical Big Data Research Center, Medical Innovation Research Department of PLA General Hospital, Beijing, 100853, People’s Republic of China; 2Graduate School of PLA General Hospital, Beijing, 100853, People’s Republic of China; 3School of Medicine, Nankai University, Tianjin, 300071, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kunlun He, Medical Big Data Research Center, Medical Innovation Research Department of PLA General Hospital, 28 Fuxing Road, Beijing, 100853, People’s Republic of China, Tel +86-10-66939107, Email kunlunhe@plagh.orgBackground: The associations of two novel inflammation biomarkers, systemic inflammation response index (SIRI) and systemic immune inflammation index (SII), with mortality risk in patients with chronic heart failure (CHF) are not well-characterized.Methods: This retrospective cohort study included patients with CHF in two medical centers of Chinese People’s Liberation Army General Hospital, Beijing, China. The outcomes of this study included in-hospital mortality and long-term mortality. Associations of SIRI and SII with mortality were assessed using multivariable regressions and receiver operating characteristic (ROC) analyses.Results: A total of 6232 patients with CHF were included in the present study. We documented 97 cases of in-hospital mortality and 1738 cases of long-term mortality during an average 5.01-year follow-up. Compared with patients in the lowest quartile of SIRI, those in the highest quartile exhibited 134% higher risk of in-hospital mortality (adjusted odds ratio, 2.34; 95% confidence interval [CI], 1.16– 4.72) and 45% higher risk of long-term mortality (adjusted hazard ratio, 1.45; 95% CI, 1.25– 1.67). Compared with patients in the lowest quartile of SII, those in the highest quartile exhibited 27% higher risk of long-term mortality (adjusted hazard ratio, 1.27; 95% CI, 1.11– 1.46). In ROC analyses, SIRI showed better prognostic discrimination than C-reactive protein (area under the curve: 69.39 vs 60.91, P = 0.01, for in-hospital mortality; 61.82 vs 58.67, P = 0.03, for 3-year mortality), whereas SII showed similar prognostic value with C-reactive protein.Conclusion: SIRI and SII were significantly associated with mortality risk in patients with CHF. SIRI may provide better prognostic discrimination than C-reactive protein.Keywords: systemic inflammation, systemic immune inflammation index, systemic inflammation response index, chronic heart failure, mortality riskhttps://www.dovepress.com/the-associations-of-two-novel-inflammation-biomarkers-siri-and-sii-wit-peer-reviewed-fulltext-article-JIRsystemic inflammationsystemic immune inflammation indexsystemic inflammation response indexchronic heart failuremortality risk. |
| spellingShingle | Zhu D Wang C Zhou Y Che H Wang R Cheng L Rao C Zhong Q Li Z Duan Y He K The Associations of Two Novel Inflammation Biomarkers, SIRI and SII, with Mortality Risk in Patients with Chronic Heart Failure Journal of Inflammation Research systemic inflammation systemic immune inflammation index systemic inflammation response index chronic heart failure mortality risk. |
| title | The Associations of Two Novel Inflammation Biomarkers, SIRI and SII, with Mortality Risk in Patients with Chronic Heart Failure |
| title_full | The Associations of Two Novel Inflammation Biomarkers, SIRI and SII, with Mortality Risk in Patients with Chronic Heart Failure |
| title_fullStr | The Associations of Two Novel Inflammation Biomarkers, SIRI and SII, with Mortality Risk in Patients with Chronic Heart Failure |
| title_full_unstemmed | The Associations of Two Novel Inflammation Biomarkers, SIRI and SII, with Mortality Risk in Patients with Chronic Heart Failure |
| title_short | The Associations of Two Novel Inflammation Biomarkers, SIRI and SII, with Mortality Risk in Patients with Chronic Heart Failure |
| title_sort | associations of two novel inflammation biomarkers siri and sii with mortality risk in patients with chronic heart failure |
| topic | systemic inflammation systemic immune inflammation index systemic inflammation response index chronic heart failure mortality risk. |
| url | https://www.dovepress.com/the-associations-of-two-novel-inflammation-biomarkers-siri-and-sii-wit-peer-reviewed-fulltext-article-JIR |
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