Whole-Transcriptome Analysis of Repeated Low-Level Sarin-Exposed Rat Hippocampus and Identification of Cerna Networks to Investigate the Mechanism of Sarin-Induced Cognitive Impairment

Whole-Transcriptome Analysis of Repeated Low-Level Sarin-Exposed Rat Hippocampus and Identification of Cerna Networks to Investigate the Mechanism of Sarin-Induced Cognitive Impairment

Sarin is a potent organophosphorus nerve agent that causes cognitive dysfunction, but its underlying molecular mechanisms are poorly understood. In this study, a rat model of repeated low-level sarin exposure was established using the subcutaneous injection of 0.4 × LD<sub>50</sub> for 2...

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Bibliographic Details
Main Authors: Jingjing Shi, Dongxin Liu, Qian Jin, Xuejun Chen, Ruihua Zhang, Tong Shi, Siqing Zhu, Yi Zhang, Xingxing Zong, Chen Wang, Liqin Li
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Biology
Subjects:
sarin
cognitive impairment
synaptic plasticity
whole-transcriptome
circRNA
lncRNA
Online Access:https://www.mdpi.com/2079-7737/12/4/627

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