Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database
Coronavirus disease 2019 (COVID-19) could be a risk factor for acute ischemic stroke (AIS) due to the altered coagulation process and hyperinflammation. This study examined the risk factors, clinical profile, and hospital outcomes of COVID-19 hospitalizations with AIS. This study was a retrospective...
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MDPI AG
2022-09-01
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| 丛编: | Brain Sciences |
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| 在线阅读: | https://www.mdpi.com/2076-3425/12/9/1177 |
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| author | Muni Rubens Anshul Saxena Venkataraghavan Ramamoorthy Md Ashfaq Ahmed Zhenwei Zhang Peter McGranaghan Emir Veledar Michael McDermott Felipe De Los Rios La Rosa |
| author_facet | Muni Rubens Anshul Saxena Venkataraghavan Ramamoorthy Md Ashfaq Ahmed Zhenwei Zhang Peter McGranaghan Emir Veledar Michael McDermott Felipe De Los Rios La Rosa |
| author_sort | Muni Rubens |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) could be a risk factor for acute ischemic stroke (AIS) due to the altered coagulation process and hyperinflammation. This study examined the risk factors, clinical profile, and hospital outcomes of COVID-19 hospitalizations with AIS. This study was a retrospective analysis of data from California State Inpatient Database (SID) during 2019 and 2020. COVID-19 hospitalizations with age ≥ 18 years during 2020 and a historical cohort without COVID-19 from 2019 were included in the analysis. The primary outcomes studied were in-hospital mortality and discharge to destinations other than home. There were 91,420 COVID-19 hospitalizations, of which, 1027 (1.1%) had AIS. The historical control cohort included 58,083 AIS hospitalizations without COVID-19. Conditional logistic regression analysis showed that the odds of in-hospital mortality, discharge to destinations other than home, DVT, pulmonary embolism, septic shock, and mechanical ventilation were significantly higher among COVID-19 hospitalizations with AIS, compared to those without AIS. The odds of in-hospital mortality, DVT, pulmonary embolism, septic shock, mechanical ventilation, and respiratory failure were significantly higher among COVID-19 hospitalizations with AIS, compared to AIS hospitalizations without COVID-19. Although the prevalence of AIS was low among COVID-19 hospitalizations, it was associated with higher mortality and greater rates of discharges to destinations other than home. |
| first_indexed | 2024-03-10T00:33:33Z |
| format | Article |
| id | doaj.art-8e34b9edb0574221996af8cdad78c8a2 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T00:33:33Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-8e34b9edb0574221996af8cdad78c8a22023-11-23T15:20:31ZengMDPI AGBrain Sciences2076-34252022-09-01129117710.3390/brainsci12091177Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient DatabaseMuni Rubens0Anshul Saxena1Venkataraghavan Ramamoorthy2Md Ashfaq Ahmed3Zhenwei Zhang4Peter McGranaghan5Emir Veledar6Michael McDermott7Felipe De Los Rios La Rosa8Miami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USACenter for Advanced Analytics, Baptist Health South Florida, Miami, FL 33176, USACenter for Advanced Analytics, Baptist Health South Florida, Miami, FL 33176, USACenter for Advanced Analytics, Baptist Health South Florida, Miami, FL 33176, USACenter for Advanced Analytics, Baptist Health South Florida, Miami, FL 33176, USAMiami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USACenter for Advanced Analytics, Baptist Health South Florida, Miami, FL 33176, USADepartment of Neurology, Florida International University, Miami, FL 33199, USAMiami Neuroscience Institute, Baptist Health South Florida, Miami, FL 33176, USACoronavirus disease 2019 (COVID-19) could be a risk factor for acute ischemic stroke (AIS) due to the altered coagulation process and hyperinflammation. This study examined the risk factors, clinical profile, and hospital outcomes of COVID-19 hospitalizations with AIS. This study was a retrospective analysis of data from California State Inpatient Database (SID) during 2019 and 2020. COVID-19 hospitalizations with age ≥ 18 years during 2020 and a historical cohort without COVID-19 from 2019 were included in the analysis. The primary outcomes studied were in-hospital mortality and discharge to destinations other than home. There were 91,420 COVID-19 hospitalizations, of which, 1027 (1.1%) had AIS. The historical control cohort included 58,083 AIS hospitalizations without COVID-19. Conditional logistic regression analysis showed that the odds of in-hospital mortality, discharge to destinations other than home, DVT, pulmonary embolism, septic shock, and mechanical ventilation were significantly higher among COVID-19 hospitalizations with AIS, compared to those without AIS. The odds of in-hospital mortality, DVT, pulmonary embolism, septic shock, mechanical ventilation, and respiratory failure were significantly higher among COVID-19 hospitalizations with AIS, compared to AIS hospitalizations without COVID-19. Although the prevalence of AIS was low among COVID-19 hospitalizations, it was associated with higher mortality and greater rates of discharges to destinations other than home.https://www.mdpi.com/2076-3425/12/9/1177coronavirusdeathhospitalizationischemic strokemorbidity |
| spellingShingle | Muni Rubens Anshul Saxena Venkataraghavan Ramamoorthy Md Ashfaq Ahmed Zhenwei Zhang Peter McGranaghan Emir Veledar Michael McDermott Felipe De Los Rios La Rosa Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database Brain Sciences coronavirus death hospitalization ischemic stroke morbidity |
| title | Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database |
| title_full | Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database |
| title_fullStr | Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database |
| title_full_unstemmed | Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database |
| title_short | Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database |
| title_sort | hospital outcomes among covid 19 hospitalizations with acute ischemic stroke cross sectional study results from california state inpatient database |
| topic | coronavirus death hospitalization ischemic stroke morbidity |
| url | https://www.mdpi.com/2076-3425/12/9/1177 |
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