Anti-tumor targeted drug delivery systems mediated by aminopeptidase N/CD13
Aminopeptidase N (APN)/CD13 is a transmembrane glycoprotein, which is overexpressed on tumor neovascular endothelial cells and most tumor cells, where it plays an important role in tumor angiogenesis. Peptides containing the Asn-Gly-Arg (NGR) motif can specifically recognize APN/CD13 allowing them t...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2011-08-01
|
| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383511000402 |
| _version_ | 1818893985874182144 |
|---|---|
| author | Xun Wang Bin Wang Qiang Zhang |
| author_facet | Xun Wang Bin Wang Qiang Zhang |
| author_sort | Xun Wang |
| collection | DOAJ |
| description | Aminopeptidase N (APN)/CD13 is a transmembrane glycoprotein, which is overexpressed on tumor neovascular endothelial cells and most tumor cells, where it plays an important role in tumor angiogenesis. Peptides containing the Asn-Gly-Arg (NGR) motif can specifically recognize APN/CD13 allowing them to act as tumor-homing peptides for the targeted delivery of anti-tumor drugs to tumor neovascular endothelial cells and tumor cells. This article reviews the literature and recent developments related to APN/CD13, its role in tumor growth and some anti-tumor drug delivery systems containing NGR peptides designed to target APN/CD13. |
| first_indexed | 2024-12-19T18:21:18Z |
| format | Article |
| id | doaj.art-8e3533d4f65641749a41bbdb2123e5bf |
| institution | Directory Open Access Journal |
| issn | 2211-3835 2211-3843 |
| language | English |
| last_indexed | 2024-12-19T18:21:18Z |
| publishDate | 2011-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-8e3533d4f65641749a41bbdb2123e5bf2022-12-21T20:10:59ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432011-08-0112808310.1016/j.apsb.2011.06.002Anti-tumor targeted drug delivery systems mediated by aminopeptidase N/CD13Xun Wang0Bin Wang1Qiang Zhang2School of Pharmaceutical Sciences, Peking University, Beijing 100191, ChinaDepartment of Endocrinology, Guang'an men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaSchool of Pharmaceutical Sciences, Peking University, Beijing 100191, ChinaAminopeptidase N (APN)/CD13 is a transmembrane glycoprotein, which is overexpressed on tumor neovascular endothelial cells and most tumor cells, where it plays an important role in tumor angiogenesis. Peptides containing the Asn-Gly-Arg (NGR) motif can specifically recognize APN/CD13 allowing them to act as tumor-homing peptides for the targeted delivery of anti-tumor drugs to tumor neovascular endothelial cells and tumor cells. This article reviews the literature and recent developments related to APN/CD13, its role in tumor growth and some anti-tumor drug delivery systems containing NGR peptides designed to target APN/CD13.http://www.sciencedirect.com/science/article/pii/S2211383511000402Aminopeptidase N/CD13NGR peptidesAnti-tumorTargeted drug delivery system |
| spellingShingle | Xun Wang Bin Wang Qiang Zhang Anti-tumor targeted drug delivery systems mediated by aminopeptidase N/CD13 Acta Pharmaceutica Sinica B Aminopeptidase N/CD13 NGR peptides Anti-tumor Targeted drug delivery system |
| title | Anti-tumor targeted drug delivery systems mediated by aminopeptidase N/CD13 |
| title_full | Anti-tumor targeted drug delivery systems mediated by aminopeptidase N/CD13 |
| title_fullStr | Anti-tumor targeted drug delivery systems mediated by aminopeptidase N/CD13 |
| title_full_unstemmed | Anti-tumor targeted drug delivery systems mediated by aminopeptidase N/CD13 |
| title_short | Anti-tumor targeted drug delivery systems mediated by aminopeptidase N/CD13 |
| title_sort | anti tumor targeted drug delivery systems mediated by aminopeptidase n cd13 |
| topic | Aminopeptidase N/CD13 NGR peptides Anti-tumor Targeted drug delivery system |
| url | http://www.sciencedirect.com/science/article/pii/S2211383511000402 |
| work_keys_str_mv | AT xunwang antitumortargeteddrugdeliverysystemsmediatedbyaminopeptidasencd13 AT binwang antitumortargeteddrugdeliverysystemsmediatedbyaminopeptidasencd13 AT qiangzhang antitumortargeteddrugdeliverysystemsmediatedbyaminopeptidasencd13 |