MSH2 Overexpression Due to an Unclassified Variant in 3’-Untranslated Region in a Patient with Colon Cancer

MSH2 Overexpression Due to an Unclassified Variant in 3’-Untranslated Region in a Patient with Colon Cancer

Background: The loss or low expression of DNA mismatch repair (MMR) genes can result in genomic instability and tumorigenesis. One such gene, MSH2, is mutated or rearranged in Lynch syndrome (LS), which is characterized by a high risk of tumor development, including colorectal cancer. However, many...

Full description

Bibliographic Details
Main Authors: Raffaella Liccardo, Antonio Nolano, Matilde Lambiase, Carlo Della Ragione, Marina De Rosa, Paola Izzo, Francesca Duraturo
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Biomedicines
Subjects:
MSH2 3’UTR variant
hereditary colon cancer
Lynch syndrome
MSH2 protein
over expression MSH2
MMR gene
Online Access:https://www.mdpi.com/2227-9059/8/6/167

Similar Items

Similar Items