The pleotropic role of statins: Could it be the imminent host modulation agent in periodontics?
Periodontal disease is a chronic inflammatory disease which represents a primarily anaerobic Gram-negative oral infection that results in gingival inflammation, loss of attachment, bone destruction. Bacterial endotoxins in the form of lipopolysaccharides (LPS) that are instrumental in generating a h...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Dental Research Journal |
| Subjects: | |
| Online Access: | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2013;volume=10;issue=2;spage=143;epage=148;aulast=Grover |
| _version_ | 1818309897674031104 |
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| author | Harpreet Singh Grover Shailly Luthra Shruti Maroo Niteeka Maroo |
| author_facet | Harpreet Singh Grover Shailly Luthra Shruti Maroo Niteeka Maroo |
| author_sort | Harpreet Singh Grover |
| collection | DOAJ |
| description | Periodontal disease is a chronic inflammatory disease which represents a primarily anaerobic Gram-negative oral infection that results in gingival inflammation, loss of attachment, bone destruction. Bacterial endotoxins in the form of lipopolysaccharides (LPS) that are instrumental in generating a host-mediated tissue destructive immune response by mobilizing their defensive cells and releasing cytokines like Interleukin-1β (IL-1β), Tumor Necrosis Factor-α (TNF-α), and Interleukin-6 (IL-6), which lead to tissue destruction by stimulating the production of the collagenolytic enzymes: Matrix metalloproteinases (MMPs). Since the host-mediated tissue destruction is to be controlled, various means have been employed for modulating this response. Statins, 3-hydroxy-3-methylglutarylcoenzyme A (HMG CoA) reductase inhibitors, besides having lipid-lowering abilities also have antioxidant, antithrombotic, anti-inflammatory, immunomodulatory and osteomodulatory properties . All of these pleiotropic effects of statins point out to it perhaps becoming the novel host modulation agent in periodontics. |
| first_indexed | 2024-12-13T07:37:28Z |
| format | Article |
| id | doaj.art-8e35cdba8fdf49f7bcc5e9d2200d9603 |
| institution | Directory Open Access Journal |
| issn | 1735-3327 2008-0255 |
| language | English |
| last_indexed | 2024-12-13T07:37:28Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dental Research Journal |
| spelling | doaj.art-8e35cdba8fdf49f7bcc5e9d2200d96032022-12-21T23:55:02ZengWolters Kluwer Medknow PublicationsDental Research Journal1735-33272008-02552013-01-0110214314810.4103/1735-3327.113319The pleotropic role of statins: Could it be the imminent host modulation agent in periodontics?Harpreet Singh GroverShailly LuthraShruti MarooNiteeka MarooPeriodontal disease is a chronic inflammatory disease which represents a primarily anaerobic Gram-negative oral infection that results in gingival inflammation, loss of attachment, bone destruction. Bacterial endotoxins in the form of lipopolysaccharides (LPS) that are instrumental in generating a host-mediated tissue destructive immune response by mobilizing their defensive cells and releasing cytokines like Interleukin-1β (IL-1β), Tumor Necrosis Factor-α (TNF-α), and Interleukin-6 (IL-6), which lead to tissue destruction by stimulating the production of the collagenolytic enzymes: Matrix metalloproteinases (MMPs). Since the host-mediated tissue destruction is to be controlled, various means have been employed for modulating this response. Statins, 3-hydroxy-3-methylglutarylcoenzyme A (HMG CoA) reductase inhibitors, besides having lipid-lowering abilities also have antioxidant, antithrombotic, anti-inflammatory, immunomodulatory and osteomodulatory properties . All of these pleiotropic effects of statins point out to it perhaps becoming the novel host modulation agent in periodontics.http://www.drjjournal.net/article.asp?issn=1735-3327;year=2013;volume=10;issue=2;spage=143;epage=148;aulast=GroverAnti-inflammatoryhost modulationimmunomodulationosseo-modulatoryperiodonticsstatins |
| spellingShingle | Harpreet Singh Grover Shailly Luthra Shruti Maroo Niteeka Maroo The pleotropic role of statins: Could it be the imminent host modulation agent in periodontics? Dental Research Journal Anti-inflammatory host modulation immunomodulation osseo-modulatory periodontics statins |
| title | The pleotropic role of statins: Could it be the imminent host modulation agent in periodontics? |
| title_full | The pleotropic role of statins: Could it be the imminent host modulation agent in periodontics? |
| title_fullStr | The pleotropic role of statins: Could it be the imminent host modulation agent in periodontics? |
| title_full_unstemmed | The pleotropic role of statins: Could it be the imminent host modulation agent in periodontics? |
| title_short | The pleotropic role of statins: Could it be the imminent host modulation agent in periodontics? |
| title_sort | pleotropic role of statins could it be the imminent host modulation agent in periodontics |
| topic | Anti-inflammatory host modulation immunomodulation osseo-modulatory periodontics statins |
| url | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2013;volume=10;issue=2;spage=143;epage=148;aulast=Grover |
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