HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1

HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1

Abstract Background Castration-resistant prostate cancer (CRPC) is refractory to hormone treatment, and the underlying mechanism has not been fully elucidated. This study aimed to clarify the role and mechanism of Human antigen R (HuR) as a therapeutic target for CRPC progression. Methods HuR was kn...

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Bibliographic Details
Main Authors: Hang You, Guojing Song, Zhizhen Xu, Saipeng Chen, Wenhao Shen, Heting Liu, Bingqian Deng, Jun Li, Gang Huang
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Translational Medicine
Subjects:
Human antigen R
Branched-chain amino transferase 1
Castration-resistant prostate cancer
ERK5
KH-3
Online Access:https://doi.org/10.1186/s12967-024-04970-w

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