HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1
Abstract Background Castration-resistant prostate cancer (CRPC) is refractory to hormone treatment, and the underlying mechanism has not been fully elucidated. This study aimed to clarify the role and mechanism of Human antigen R (HuR) as a therapeutic target for CRPC progression. Methods HuR was kn...
Main Authors: | Hang You, Guojing Song, Zhizhen Xu, Saipeng Chen, Wenhao Shen, Heting Liu, Bingqian Deng, Jun Li, Gang Huang |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2024-02-01
|
Series: | Journal of Translational Medicine |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12967-024-04970-w |
Similar Items
-
Identification, Expression Analysis and Cloning of Capsicum chinense BCAT Gene Family
by: Bingchun XIE, et al.
Published: (2022-12-01) -
Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation
by: Feng Yang, et al.
Published: (2019-11-01) -
The mechanism of branched-chain amino acid transferases in different diseases: Research progress and future prospects
by: Xiazhen Nong, et al.
Published: (2022-09-01) -
Review: castration – animal welfare considerations
by: Gabriela A. Marquette, et al.
Published: (2023-12-01) -
Expressions of HuR, Methyl-HuR and Phospho-HuR in Endometrial Endometrioid Adenocarcinoma Are Associated with Clinical Features
by: Judicaël Hotton, et al.
Published: (2024-01-01)