Extracellular vesicles produced by irradiated endothelial or Glioblastoma stem cells promote tumor growth and vascularization modulating tumor microenvironment

Extracellular vesicles produced by irradiated endothelial or Glioblastoma stem cells promote tumor growth and vascularization modulating tumor microenvironment

Abstract Background Glioblastoma (GBM) is the most lethal primary brain tumor in adult, characterized by highly aggressive and infiltrative growth. The current therapeutic management of GBM includes surgical resection followed by ionizing radiations and chemotherapy. Complex and dynamic interplay be...

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Main Authors: Giorgia Castellani, Mariachiara Buccarelli, Quintino Giorgio D’Alessandris, Ramona Ilari, Andrea Cappannini, Francesca Pedini, Alessandra Boe, Valentina Lulli, Isabella Parolini, Stefano Giannetti, Mauro Biffoni, Vincenzo Zappavigna, Giovanna Marziali, Roberto Pallini, Lucia Ricci-Vitiani
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cancer Cell International
Subjects:
Glioblastoma
Glioblastoma stem cells
Extracellular vesicles
Endothelial cells
Tumor microenvironment
Periostin
Online Access:https://doi.org/10.1186/s12935-024-03253-0

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