Geranylgeranylacetone attenuates cerebral ischemia–reperfusion injury in rats through the augmentation of HSP 27 phosphorylation: a preliminary study

Geranylgeranylacetone attenuates cerebral ischemia–reperfusion injury in rats through the augmentation of HSP 27 phosphorylation: a preliminary study

Abstract Background We previously reported that heat shock protein 27 (HSP27) phosphorylation plays an important role in the activation of glucose-6-phosphate dehydrogenase (G6PD), resulting in the upregulation of the pentose phosphate pathway and antioxidant effects against cerebral ischemia–reperf...

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Bibliographic Details
Main Authors: Kazuya Matsuo, Kohkichi Hosoda, Jun Tanaka, Yusuke Yamamoto, Taichiro Imahori, Tomoaki Nakai, Yasuhiro Irino, Masakazu Shinohara, Takashi Sasayama, Eiji Kohmura
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Neuroscience
Subjects:
Glucose-6-phosphate dehydrogenase
Heat shock protein
Metabolomics
Oxidative stress
Reperfusion injury
Stroke
Online Access:https://doi.org/10.1186/s12868-021-00614-7

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