Heme biosensor-guided in vivo pathway optimization and directed evolution for efficient biosynthesis of heme

Heme biosensor-guided in vivo pathway optimization and directed evolution for efficient biosynthesis of heme

Abstract Background Heme has attracted much attention because of its wide applications in medicine and food. The products of genes hemBCDEFY convert 5-aminolevulinic acid to protoporphyrin IX (PPIX; the immediate precursor of heme); protoporphyrin ferrochelatase (FECH) inserts Fe2+ into PPIX to gene...

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Bibliographic Details
Main Authors: Jian Zhang, Qingbin Li, Qi Wang, Jingyu Zhao, Yuan Zhu, Tianyuan Su, Qingsheng Qi, Qian Wang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Biotechnology for Biofuels and Bioproducts
Subjects:
Heme biosynthesis
Biosensor-based high-throughput screening
In vivo evolution
Protoporphyrin IX
Online Access:https://doi.org/10.1186/s13068-023-02285-4

Internet

https://doi.org/10.1186/s13068-023-02285-4

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