Different predictors of right and left ventricular metabolism in healthy middle-aged men
Dysfunction of the right ventricle (RV) plays a crucial role in the outcome of various cardiovascular diseases. Previous studies on RV metabolism are sparse although evidence implies it may differ from left ventricular (LV) metabolism. Therefore, the aims of this study were 1) to determine predictor...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-12-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00389/full |
| _version_ | 1818893986108014592 |
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| author | Marja eHeiskanen Tuija eLeskinen Jari-Joonas eEskelinen Ilkka HA Heinonen Ilkka HA Heinonen Eliisa eLöyttyniemi Kirsi eVirtanen Jussi ePärkkä Jarna eHannukainen Kari eKalliokoski |
| author_facet | Marja eHeiskanen Tuija eLeskinen Jari-Joonas eEskelinen Ilkka HA Heinonen Ilkka HA Heinonen Eliisa eLöyttyniemi Kirsi eVirtanen Jussi ePärkkä Jarna eHannukainen Kari eKalliokoski |
| author_sort | Marja eHeiskanen |
| collection | DOAJ |
| description | Dysfunction of the right ventricle (RV) plays a crucial role in the outcome of various cardiovascular diseases. Previous studies on RV metabolism are sparse although evidence implies it may differ from left ventricular (LV) metabolism. Therefore, the aims of this study were 1) to determine predictors of RV glucose uptake (GU) and free fatty acid uptake (FFAU) and 2) to compare them to predictors of LV metabolism in healthy middle-aged men. Altogether 28 healthy, sedentary, middle-aged (40-55 years) men were studied. Insulin-stimulated GU and fasting FFAU were measured by positron emission tomography and RV and LV structural and functional parameters by cardiac magnetic resonance. Several parameters related to whole-body health were also measured. Predictors of RV and LV metabolism were determined by pairwise correlation analysis, lasso regression models, and variable clustering using heatmap. RVGU was most strongly predicted by age and moderately by RV ejection fraction (EF). The strongest determinants of RVFFAU were exercise capacity (peak oxygen uptake), resting heart rate, LVEF, and whole-body insulin-stimulated glucose uptake rate. When considering LV metabolism, age and RVEF were associated also with LVGU. In addition, LVGU was strongly, and negatively, influenced by whole-body insulin-stimulated glucose uptake rate. LVFFAU was predicted only by LVEF. This study shows that while RV and LV metabolism have shared characteristics, they also have unique properties. Age of the subject should be taken into account when measuring myocardial glucose utilization. Ejection fraction is related to myocardial metabolism, and even so that RVEF may be more closely related to GU of both ventricles and LVEF to FFAU of both ventricles, a finding supporting the ventricular interdependence. However, only RV fatty acid utilization associates with exercise capacity so that better physical fitness in a relatively sedentary population is related with decreased RV fat metabolism. To conclude, this study highlights the need for further study designed specifically on less-known RV, as the results on LV metabolism and physiology may not be directly applicable to the RV. |
| first_indexed | 2024-12-19T18:21:18Z |
| format | Article |
| id | doaj.art-8e3ade2822e64fd0b9c3bcda1c752d5f |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-19T18:21:18Z |
| publishDate | 2015-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-8e3ade2822e64fd0b9c3bcda1c752d5f2022-12-21T20:10:59ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2015-12-01610.3389/fphys.2015.00389173475Different predictors of right and left ventricular metabolism in healthy middle-aged menMarja eHeiskanen0Tuija eLeskinen1Jari-Joonas eEskelinen2Ilkka HA Heinonen3Ilkka HA Heinonen4Eliisa eLöyttyniemi5Kirsi eVirtanen6Jussi ePärkkä7Jarna eHannukainen8Kari eKalliokoski9University of TurkuUniversity of TurkuUniversity of TurkuUniversity of TurkuUniversity Of Western AustraliaUniversity of TurkuUniversity of TurkuUniversity of TurkuUniversity of TurkuUniversity of TurkuDysfunction of the right ventricle (RV) plays a crucial role in the outcome of various cardiovascular diseases. Previous studies on RV metabolism are sparse although evidence implies it may differ from left ventricular (LV) metabolism. Therefore, the aims of this study were 1) to determine predictors of RV glucose uptake (GU) and free fatty acid uptake (FFAU) and 2) to compare them to predictors of LV metabolism in healthy middle-aged men. Altogether 28 healthy, sedentary, middle-aged (40-55 years) men were studied. Insulin-stimulated GU and fasting FFAU were measured by positron emission tomography and RV and LV structural and functional parameters by cardiac magnetic resonance. Several parameters related to whole-body health were also measured. Predictors of RV and LV metabolism were determined by pairwise correlation analysis, lasso regression models, and variable clustering using heatmap. RVGU was most strongly predicted by age and moderately by RV ejection fraction (EF). The strongest determinants of RVFFAU were exercise capacity (peak oxygen uptake), resting heart rate, LVEF, and whole-body insulin-stimulated glucose uptake rate. When considering LV metabolism, age and RVEF were associated also with LVGU. In addition, LVGU was strongly, and negatively, influenced by whole-body insulin-stimulated glucose uptake rate. LVFFAU was predicted only by LVEF. This study shows that while RV and LV metabolism have shared characteristics, they also have unique properties. Age of the subject should be taken into account when measuring myocardial glucose utilization. Ejection fraction is related to myocardial metabolism, and even so that RVEF may be more closely related to GU of both ventricles and LVEF to FFAU of both ventricles, a finding supporting the ventricular interdependence. However, only RV fatty acid utilization associates with exercise capacity so that better physical fitness in a relatively sedentary population is related with decreased RV fat metabolism. To conclude, this study highlights the need for further study designed specifically on less-known RV, as the results on LV metabolism and physiology may not be directly applicable to the RV.http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00389/fullExerciseHeartMagnetic Resonance ImagingMetabolismPositron-Emission Tomographyglucose uptake |
| spellingShingle | Marja eHeiskanen Tuija eLeskinen Jari-Joonas eEskelinen Ilkka HA Heinonen Ilkka HA Heinonen Eliisa eLöyttyniemi Kirsi eVirtanen Jussi ePärkkä Jarna eHannukainen Kari eKalliokoski Different predictors of right and left ventricular metabolism in healthy middle-aged men Frontiers in Physiology Exercise Heart Magnetic Resonance Imaging Metabolism Positron-Emission Tomography glucose uptake |
| title | Different predictors of right and left ventricular metabolism in healthy middle-aged men |
| title_full | Different predictors of right and left ventricular metabolism in healthy middle-aged men |
| title_fullStr | Different predictors of right and left ventricular metabolism in healthy middle-aged men |
| title_full_unstemmed | Different predictors of right and left ventricular metabolism in healthy middle-aged men |
| title_short | Different predictors of right and left ventricular metabolism in healthy middle-aged men |
| title_sort | different predictors of right and left ventricular metabolism in healthy middle aged men |
| topic | Exercise Heart Magnetic Resonance Imaging Metabolism Positron-Emission Tomography glucose uptake |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00389/full |
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