Changes in adipokine levels and metabolic profiles following bariatric surgery
Abstract Background Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients. Abdominal obesity is frequently accompanied by metabolic syndrome (MS). Adipokines are cell signaling proteins that have direct impact upon the metabolic homeostasis....
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-022-00942-7 |
| _version_ | 1818083045809324032 |
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| author | Natalja Šebunova Jelena Štšepetova Tiiu Kullisaar Kadri Suija Anneli Rätsep Igor Junkin Hiie Soeorg Margus Lember Toomas Sillakivi Reet Mändar |
| author_facet | Natalja Šebunova Jelena Štšepetova Tiiu Kullisaar Kadri Suija Anneli Rätsep Igor Junkin Hiie Soeorg Margus Lember Toomas Sillakivi Reet Mändar |
| author_sort | Natalja Šebunova |
| collection | DOAJ |
| description | Abstract Background Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients. Abdominal obesity is frequently accompanied by metabolic syndrome (MS). Adipokines are cell signaling proteins that have direct impact upon the metabolic homeostasis. The purpose of this analysis was to evaluate the effect of bariatric surgery, including laparoscopic sleeve gastrectomy (LSG) and laparoscopic gastric bypass (LRYGB) on the adipokine levels and metabolic profile as well as MS and status of type 2 diabetes (T2D). Methods We analyzed anthropometric parameters, blood levels of adipokines, vitamins, lipids and inflammatory markers in 30 bariatric surgery patients with obesity of class II or III 1 month before and 1 year after surgery as well as in 60 obese patients from general practice (GP) and 15 patients with normal body mass (control). Results The BMI was significantly higher among patients before surgery and GP patients in comparison to control and post-surgery patients. The levels of glucose, cholesterol and LDL-cholesterol, triglyceride and hs-CRP were the highest in patients before surgery but decreased significantly after surgery, while the level of HDL-cholesterol increased after surgery. The levels of adiponectin increased and that of leptin decreased after surgery. The significant difference in the concentration of resistin was revealed between LSG and LRYGB methods. The relationship between resistin and vitamin D was also found. The patients with MS and T2D displayed significantly greater reduction in lipid markers and adipokine levels than the rest of patients. Conclusion Remarkable changes in levels of adipokines after bariatric surgery appear like increase in adiponectin and decrease in leptin levels. Significant improvement in anthropometric parameters, metabolic and inflammatory markers occurs, suggesting high potential for reduction of metabolic syndrome and risk for type 2 diabetes. We have shown for the first time ever that level of vitamin D may be involved in resistin regulation. |
| first_indexed | 2024-12-10T19:31:45Z |
| format | Article |
| id | doaj.art-8e3aec10ed784490a8d167c424fa47a2 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-10T19:31:45Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-8e3aec10ed784490a8d167c424fa47a22022-12-22T01:36:14ZengBMCBMC Endocrine Disorders1472-68232022-02-0122111210.1186/s12902-022-00942-7Changes in adipokine levels and metabolic profiles following bariatric surgeryNatalja Šebunova0Jelena Štšepetova1Tiiu Kullisaar2Kadri Suija3Anneli Rätsep4Igor Junkin5Hiie Soeorg6Margus Lember7Toomas Sillakivi8Reet Mändar9Department of Microbiology, Institute of Biomedicine and Translational Medicine, University of TartuDepartment of Microbiology, Institute of Biomedicine and Translational Medicine, University of TartuDepartment of Biochemistry, Institute of Biomedicine and Translational Medicine, University of TartuDepartment of Family Medicine, Faculty of Medicine, Institute of Family Medicine and Public Health, University of TartuDepartment of Family Medicine, Faculty of Medicine, Institute of Family Medicine and Public Health, University of TartuDepartment of Family Medicine, Faculty of Medicine, Institute of Family Medicine and Public Health, University of TartuDepartment of Microbiology, Institute of Biomedicine and Translational Medicine, University of TartuDepartment of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, University of TartuAbdominal Surgery Department, Tartu University HospitalDepartment of Microbiology, Institute of Biomedicine and Translational Medicine, University of TartuAbstract Background Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients. Abdominal obesity is frequently accompanied by metabolic syndrome (MS). Adipokines are cell signaling proteins that have direct impact upon the metabolic homeostasis. The purpose of this analysis was to evaluate the effect of bariatric surgery, including laparoscopic sleeve gastrectomy (LSG) and laparoscopic gastric bypass (LRYGB) on the adipokine levels and metabolic profile as well as MS and status of type 2 diabetes (T2D). Methods We analyzed anthropometric parameters, blood levels of adipokines, vitamins, lipids and inflammatory markers in 30 bariatric surgery patients with obesity of class II or III 1 month before and 1 year after surgery as well as in 60 obese patients from general practice (GP) and 15 patients with normal body mass (control). Results The BMI was significantly higher among patients before surgery and GP patients in comparison to control and post-surgery patients. The levels of glucose, cholesterol and LDL-cholesterol, triglyceride and hs-CRP were the highest in patients before surgery but decreased significantly after surgery, while the level of HDL-cholesterol increased after surgery. The levels of adiponectin increased and that of leptin decreased after surgery. The significant difference in the concentration of resistin was revealed between LSG and LRYGB methods. The relationship between resistin and vitamin D was also found. The patients with MS and T2D displayed significantly greater reduction in lipid markers and adipokine levels than the rest of patients. Conclusion Remarkable changes in levels of adipokines after bariatric surgery appear like increase in adiponectin and decrease in leptin levels. Significant improvement in anthropometric parameters, metabolic and inflammatory markers occurs, suggesting high potential for reduction of metabolic syndrome and risk for type 2 diabetes. We have shown for the first time ever that level of vitamin D may be involved in resistin regulation.https://doi.org/10.1186/s12902-022-00942-7AdipokinesBariatric surgeryMetabolic syndromeWeight lossBlood indices |
| spellingShingle | Natalja Šebunova Jelena Štšepetova Tiiu Kullisaar Kadri Suija Anneli Rätsep Igor Junkin Hiie Soeorg Margus Lember Toomas Sillakivi Reet Mändar Changes in adipokine levels and metabolic profiles following bariatric surgery BMC Endocrine Disorders Adipokines Bariatric surgery Metabolic syndrome Weight loss Blood indices |
| title | Changes in adipokine levels and metabolic profiles following bariatric surgery |
| title_full | Changes in adipokine levels and metabolic profiles following bariatric surgery |
| title_fullStr | Changes in adipokine levels and metabolic profiles following bariatric surgery |
| title_full_unstemmed | Changes in adipokine levels and metabolic profiles following bariatric surgery |
| title_short | Changes in adipokine levels and metabolic profiles following bariatric surgery |
| title_sort | changes in adipokine levels and metabolic profiles following bariatric surgery |
| topic | Adipokines Bariatric surgery Metabolic syndrome Weight loss Blood indices |
| url | https://doi.org/10.1186/s12902-022-00942-7 |
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