Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients
Objective:This study aimed to investigate the risk factors for hypothyroidism in patients with adult epilepsy patients.Methods:Hospital charts of 530 patients were reviewed retrospectively. Patients with a definite diagnosis of hypothyroidism with persistent adherence to antiseizure medications (ASM...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2023-06-01
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| Series: | Archives of Epilepsy |
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| Online Access: |
http://archepilepsy.org/archives/archive-detail/article-preview/risk-factors-for-clinically-overt-hypothyroidism-i/60571
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| _version_ | 1797767407061696512 |
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| author | Naciye Çilem Çarkı Bal Ebru Apaydın Doğan Yeşim Şenol |
| author_facet | Naciye Çilem Çarkı Bal Ebru Apaydın Doğan Yeşim Şenol |
| author_sort | Naciye Çilem Çarkı Bal |
| collection | DOAJ |
| description | Objective:This study aimed to investigate the risk factors for hypothyroidism in patients with adult epilepsy patients.Methods:Hospital charts of 530 patients were reviewed retrospectively. Patients with a definite diagnosis of hypothyroidism with persistent adherence to antiseizure medications (ASM) were included. An age and gender-matched group of 110 patients was selected as the control group.Results:The rate of hypothyroidism was significantly higher in patients with epilepsy (p=0.01). The patients with epilepsy were separated into two groups-the patients with and without hypothyroidism. The distribution of other neurologic disorders was similar in epilepsy patients with and without hypothyroidism (p=0.46). The comparison of the two groups showed that, independent of the ASM type, receiving any polytherapy regimen was a significant risk factor for hypothyroidism (p=0.02) and epilepsy patients with hypothyroidism had a longer duration of epilepsy (p=0.03). Logistic regression analysis revealed that the only independent risk factor for hypothyroidism was being on a polytherapy regimen (p=0.02).Conclusion:In this study, we found two major results: i) compared with an age and gender-matched control group, epilepsy is a major risk factor for hypothyroidism, ii) independent of the ASM type, receiving a polytherapy regimen is a predictive risk factor for hypothyroidism. |
| first_indexed | 2024-03-12T20:38:16Z |
| format | Article |
| id | doaj.art-8e3b277c61354898b9862c4b37193c30 |
| institution | Directory Open Access Journal |
| issn | 2792-0550 |
| language | English |
| last_indexed | 2024-03-12T20:38:16Z |
| publishDate | 2023-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Archives of Epilepsy |
| spelling | doaj.art-8e3b277c61354898b9862c4b37193c302023-08-01T11:14:29ZengGalenos YayineviArchives of Epilepsy2792-05502023-06-01292464910.4274/ArchEpilepsy.2023.22102113049054Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy PatientsNaciye Çilem Çarkı Bal0Ebru Apaydın Doğan1Yeşim Şenol2 Akdeniz University Faculty of Medicine, Department of Neurology, Antalya, Turkey Akdeniz University Faculty of Medicine, Department of Neurology, Antalya, Turkey Akdeniz University Faculty of Medicine, Department of Medical Education, Antalya, Turkey Objective:This study aimed to investigate the risk factors for hypothyroidism in patients with adult epilepsy patients.Methods:Hospital charts of 530 patients were reviewed retrospectively. Patients with a definite diagnosis of hypothyroidism with persistent adherence to antiseizure medications (ASM) were included. An age and gender-matched group of 110 patients was selected as the control group.Results:The rate of hypothyroidism was significantly higher in patients with epilepsy (p=0.01). The patients with epilepsy were separated into two groups-the patients with and without hypothyroidism. The distribution of other neurologic disorders was similar in epilepsy patients with and without hypothyroidism (p=0.46). The comparison of the two groups showed that, independent of the ASM type, receiving any polytherapy regimen was a significant risk factor for hypothyroidism (p=0.02) and epilepsy patients with hypothyroidism had a longer duration of epilepsy (p=0.03). Logistic regression analysis revealed that the only independent risk factor for hypothyroidism was being on a polytherapy regimen (p=0.02).Conclusion:In this study, we found two major results: i) compared with an age and gender-matched control group, epilepsy is a major risk factor for hypothyroidism, ii) independent of the ASM type, receiving a polytherapy regimen is a predictive risk factor for hypothyroidism. http://archepilepsy.org/archives/archive-detail/article-preview/risk-factors-for-clinically-overt-hypothyroidism-i/60571 hypothyroidismepilepsypolytherapy |
| spellingShingle | Naciye Çilem Çarkı Bal Ebru Apaydın Doğan Yeşim Şenol Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients Archives of Epilepsy hypothyroidism epilepsy polytherapy |
| title | Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients |
| title_full | Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients |
| title_fullStr | Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients |
| title_full_unstemmed | Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients |
| title_short | Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients |
| title_sort | risk factors for clinically overt hypothyroidism in unselected population of adult epilepsy patients |
| topic | hypothyroidism epilepsy polytherapy |
| url |
http://archepilepsy.org/archives/archive-detail/article-preview/risk-factors-for-clinically-overt-hypothyroidism-i/60571
|
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