Phytochemistry, Pharmacology and Molecular Mechanisms of Herbal Bioactive Compounds for Sickness Behaviour
The host’s response to acute infections or tissue injury is a sophisticated and coordinated adaptive modification called sickness behaviour. Many herbs have been studied for their ability to protect animals against experimentally induced sickness behaviour. However, there is a lack of knowledge and...
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MDPI AG
2022-12-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/12/1215 |
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| author | Ghallab Hamoud Sinhat Alotaibi Thippeswamy Boreddy Shivanandappa Maheswari Chinnadhurai Sudharshan Reddy Dachani Mahmad Dabeer Ahmad Khalid Abdullah Aldaajanii |
| author_facet | Ghallab Hamoud Sinhat Alotaibi Thippeswamy Boreddy Shivanandappa Maheswari Chinnadhurai Sudharshan Reddy Dachani Mahmad Dabeer Ahmad Khalid Abdullah Aldaajanii |
| author_sort | Ghallab Hamoud Sinhat Alotaibi |
| collection | DOAJ |
| description | The host’s response to acute infections or tissue injury is a sophisticated and coordinated adaptive modification called sickness behaviour. Many herbs have been studied for their ability to protect animals against experimentally induced sickness behaviour. However, there is a lack of knowledge and experimental evidence on the use of herbal bioactive compounds (HBACs) in the management of sick behaviour. The goal of this review is to provide a concise summary of the protective benefits and putative mechanisms of action of phytochemicals on the reduction of lipopolysaccharide (LPS)-induced sickness behaviour. Relevant studies were gathered from the search engines Scopus, ScienceDirect, PubMed, Google Scholar, and other scientific databases (between 2000 and to date). The keywords used for the search included “Lipopolysaccharide” OR “LPS” OR “Sickness behaviour” OR “Sickness” AND “Bioactive compounds” OR “Herbal medicine” OR “Herbal drug” OR “Natural products” OR “Isolated compounds”. A total of 41 published articles that represented data on the effect of HBACs in LPS-induced sickness behaviour were reviewed and summarised systemically. There were 33 studies that were conducted in mice and 8 studies in rats. A total of 34 HBACs have had their effects against LPS-induced changes in behaviour and biochemistry investigated. In this review, we examined 34 herbal bioactive components that have been tested in animal models to see if they can fight LPS-induced sickness behaviour. Future research should concentrate on the efficacy, safety, and dosage needed to protect against illness behaviour in humans, because there is a critical shortage of data in this area. |
| first_indexed | 2024-03-09T16:06:19Z |
| format | Article |
| id | doaj.art-8e3b5e3c42dd421ea405685fe8a3f151 |
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| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T16:06:19Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-8e3b5e3c42dd421ea405685fe8a3f1512023-11-24T16:37:39ZengMDPI AGMetabolites2218-19892022-12-011212121510.3390/metabo12121215Phytochemistry, Pharmacology and Molecular Mechanisms of Herbal Bioactive Compounds for Sickness BehaviourGhallab Hamoud Sinhat Alotaibi0Thippeswamy Boreddy Shivanandappa1Maheswari Chinnadhurai2Sudharshan Reddy Dachani3Mahmad Dabeer Ahmad4Khalid Abdullah Aldaajanii5Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Al-Dawadmi Campus, Al-Dawadmi 11961, Saudi ArabiaDepartment of Biomedical Science, College of Pharmacy, Shaqra University, Al-Dawadmi Campus, Al-Dawadmi 11961, Saudi ArabiaDepartment of Pharmacy Practice, College of Pharmacy, Shaqra University, Al-Dawadmi Campus, Al-Dawadmi 11961, Saudi ArabiaDepartment of Pharmacy Practice, College of Pharmacy, Shaqra University, Al-Dawadmi Campus, Al-Dawadmi 11961, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Al-Dawadmi Campus, Al-Dawadmi 11961, Saudi ArabiaDepartment of Biomedical Science, College of Pharmacy, Shaqra University, Al-Dawadmi Campus, Al-Dawadmi 11961, Saudi ArabiaThe host’s response to acute infections or tissue injury is a sophisticated and coordinated adaptive modification called sickness behaviour. Many herbs have been studied for their ability to protect animals against experimentally induced sickness behaviour. However, there is a lack of knowledge and experimental evidence on the use of herbal bioactive compounds (HBACs) in the management of sick behaviour. The goal of this review is to provide a concise summary of the protective benefits and putative mechanisms of action of phytochemicals on the reduction of lipopolysaccharide (LPS)-induced sickness behaviour. Relevant studies were gathered from the search engines Scopus, ScienceDirect, PubMed, Google Scholar, and other scientific databases (between 2000 and to date). The keywords used for the search included “Lipopolysaccharide” OR “LPS” OR “Sickness behaviour” OR “Sickness” AND “Bioactive compounds” OR “Herbal medicine” OR “Herbal drug” OR “Natural products” OR “Isolated compounds”. A total of 41 published articles that represented data on the effect of HBACs in LPS-induced sickness behaviour were reviewed and summarised systemically. There were 33 studies that were conducted in mice and 8 studies in rats. A total of 34 HBACs have had their effects against LPS-induced changes in behaviour and biochemistry investigated. In this review, we examined 34 herbal bioactive components that have been tested in animal models to see if they can fight LPS-induced sickness behaviour. Future research should concentrate on the efficacy, safety, and dosage needed to protect against illness behaviour in humans, because there is a critical shortage of data in this area.https://www.mdpi.com/2218-1989/12/12/1215sickness behaviourphytomedicinenatural productslipopolysaccharideacute infections |
| spellingShingle | Ghallab Hamoud Sinhat Alotaibi Thippeswamy Boreddy Shivanandappa Maheswari Chinnadhurai Sudharshan Reddy Dachani Mahmad Dabeer Ahmad Khalid Abdullah Aldaajanii Phytochemistry, Pharmacology and Molecular Mechanisms of Herbal Bioactive Compounds for Sickness Behaviour Metabolites sickness behaviour phytomedicine natural products lipopolysaccharide acute infections |
| title | Phytochemistry, Pharmacology and Molecular Mechanisms of Herbal Bioactive Compounds for Sickness Behaviour |
| title_full | Phytochemistry, Pharmacology and Molecular Mechanisms of Herbal Bioactive Compounds for Sickness Behaviour |
| title_fullStr | Phytochemistry, Pharmacology and Molecular Mechanisms of Herbal Bioactive Compounds for Sickness Behaviour |
| title_full_unstemmed | Phytochemistry, Pharmacology and Molecular Mechanisms of Herbal Bioactive Compounds for Sickness Behaviour |
| title_short | Phytochemistry, Pharmacology and Molecular Mechanisms of Herbal Bioactive Compounds for Sickness Behaviour |
| title_sort | phytochemistry pharmacology and molecular mechanisms of herbal bioactive compounds for sickness behaviour |
| topic | sickness behaviour phytomedicine natural products lipopolysaccharide acute infections |
| url | https://www.mdpi.com/2218-1989/12/12/1215 |
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