Osthole: An up-to-date review of its anticancer potential and mechanisms of action
With its high incidence and mortality rates, cancer is one of the largest health problems worldwide. Investigating various cancer treatment options has been the focus of many domestic and international researchers, and significant progress has been made in the study of the anticancer effects of trad...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.945627/full |
| _version_ | 1828409488546201600 |
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| author | Shaojie Yang Wanlin Dai Jingnan Wang Xiaolin Zhang Yuting Zheng Shiyuan Bi Liwei Pang Tengqi Ren Ye Yang Yang Sun Zhuyuan Zheng Shuodong Wu Jing Kong |
| author_facet | Shaojie Yang Wanlin Dai Jingnan Wang Xiaolin Zhang Yuting Zheng Shiyuan Bi Liwei Pang Tengqi Ren Ye Yang Yang Sun Zhuyuan Zheng Shuodong Wu Jing Kong |
| author_sort | Shaojie Yang |
| collection | DOAJ |
| description | With its high incidence and mortality rates, cancer is one of the largest health problems worldwide. Investigating various cancer treatment options has been the focus of many domestic and international researchers, and significant progress has been made in the study of the anticancer effects of traditional Chinese medicines. Osthole, a coumarin compound extracted from Cnidium monnieri (L.) Cuss., has become a new research hotspot. There have been many reports on its anticancer effects, and recent studies have elucidated that its underlying mechanism of action mainly involves inhibiting cancer cell proliferation, inducing cancer cell apoptosis, inhibiting invasion and migration of cancer cells, inhibiting cancer angiogenesis, increasing sensitivity to chemotherapy drugs, and reversing multidrug resistance of cancer cells. This mini-review summarizes the research progress on the anticancer effects of osthole in recent years. |
| first_indexed | 2024-12-10T11:55:49Z |
| format | Article |
| id | doaj.art-8e3b95e7b4e84455a9b0e350b4ef6796 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T11:55:49Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-8e3b95e7b4e84455a9b0e350b4ef67962022-12-22T01:49:47ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.945627945627Osthole: An up-to-date review of its anticancer potential and mechanisms of actionShaojie Yang0Wanlin Dai1Jingnan Wang2Xiaolin Zhang3Yuting Zheng4Shiyuan Bi5Liwei Pang6Tengqi Ren7Ye Yang8Yang Sun9Zhuyuan Zheng10Shuodong Wu11Jing Kong12Biliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaInnovation Institute of China Medical University, Shenyang, ChinaBiliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaBiliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaBiliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaBiliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaBreast Surgery Unit, Department of General Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Urinary Surgery, Taizhou Enze Medical Center (Group) Enze Hospital, Taizhou, ChinaBiliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaBiliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaBiliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaBiliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaBiliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaWith its high incidence and mortality rates, cancer is one of the largest health problems worldwide. Investigating various cancer treatment options has been the focus of many domestic and international researchers, and significant progress has been made in the study of the anticancer effects of traditional Chinese medicines. Osthole, a coumarin compound extracted from Cnidium monnieri (L.) Cuss., has become a new research hotspot. There have been many reports on its anticancer effects, and recent studies have elucidated that its underlying mechanism of action mainly involves inhibiting cancer cell proliferation, inducing cancer cell apoptosis, inhibiting invasion and migration of cancer cells, inhibiting cancer angiogenesis, increasing sensitivity to chemotherapy drugs, and reversing multidrug resistance of cancer cells. This mini-review summarizes the research progress on the anticancer effects of osthole in recent years.https://www.frontiersin.org/articles/10.3389/fphar.2022.945627/fullostholeanticancerproliferationapoptosismetastasisangiogenesis |
| spellingShingle | Shaojie Yang Wanlin Dai Jingnan Wang Xiaolin Zhang Yuting Zheng Shiyuan Bi Liwei Pang Tengqi Ren Ye Yang Yang Sun Zhuyuan Zheng Shuodong Wu Jing Kong Osthole: An up-to-date review of its anticancer potential and mechanisms of action Frontiers in Pharmacology osthole anticancer proliferation apoptosis metastasis angiogenesis |
| title | Osthole: An up-to-date review of its anticancer potential and mechanisms of action |
| title_full | Osthole: An up-to-date review of its anticancer potential and mechanisms of action |
| title_fullStr | Osthole: An up-to-date review of its anticancer potential and mechanisms of action |
| title_full_unstemmed | Osthole: An up-to-date review of its anticancer potential and mechanisms of action |
| title_short | Osthole: An up-to-date review of its anticancer potential and mechanisms of action |
| title_sort | osthole an up to date review of its anticancer potential and mechanisms of action |
| topic | osthole anticancer proliferation apoptosis metastasis angiogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.945627/full |
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