Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2

Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2

Pulmonary fibrosis (PF) is a chronic and progressive process of tissue repair. Azithromycin (AZM) may be beneficial for the treatment of PF because AZM has anti-inflammatory and immune regulatory roles and inhibits remodeling, but the mechanism is not entirely clear. In this study, we established a...

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Bibliographic Details
Main Authors: Xiang Tong, Shijie Zhang, Dongguang Wang, Li Zhang, Jizheng Huang, Tianli Zhang, Hong Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary fibrosis
azithromycin
LOX
JNK pathway
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.709819/full

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