ENDOSCOPIC AND HISTOPATHOLOGIC GASTRIC CHANGES IN CHRONIC USERS OF PROTON-PUMP INHIBITORS
Background Proton-pump inhibitors have been used for at least two decades. They are among the most commonly sold drugs in the world. However, some controversy remains about the indications for their use and the consequences of their prolonged use. Objectives To evaluate and compare the endoscopic an...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)
2015-03-01
|
| Series: | Arquivos de Gastroenterologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032015000100013&lng=en&tlng=en |
| _version_ | 1811268847128281088 |
|---|---|
| author | Sílvia Maria Perrone CAMILO Élia Cláudia de Souza ALMEIDA Benito André Silveira MIRANZI Juliano Carvalho SILVA Rosemary Simões NOMELINI Renata Margarida ETCHEBEHERE |
| author_facet | Sílvia Maria Perrone CAMILO Élia Cláudia de Souza ALMEIDA Benito André Silveira MIRANZI Juliano Carvalho SILVA Rosemary Simões NOMELINI Renata Margarida ETCHEBEHERE |
| author_sort | Sílvia Maria Perrone CAMILO |
| collection | DOAJ |
| description | Background Proton-pump inhibitors have been used for at least two decades. They are among the most commonly sold drugs in the world. However, some controversy remains about the indications for their use and the consequences of their prolonged use. Objectives To evaluate and compare the endoscopic and histopathologic gastric changes in chronic users of proton-pump inhibitors to changes in non-users. Methods A prospective study performed at a tertiary Public Hospital involving 105 patients undergoing upper-gastrointestinal endoscopy. Subjects included 81 proton-pump inhibitor users and 24 non-users (control group). Biopsies of the antral-type mucosa, the antral-fundic transition, and the fundus were evaluated by the Sydney System. The presence of erosion or ulceration, lymphatic follicles, reactive gastropathy, and polypoid or epithelial hyperplasia was also determined. Serum levels of gastrin were measured. Results We found two polyps, one in each group, both of which were negative for Helicobacter pylori. There were two cases of parietal cell hyperplasia in users of proton-pump inhibitors. Gastrin was elevated in 28 users of proton-pump inhibitors and in four members of the control group. We did not find statistically significant differences in the endoscopic or histopathologic findings between the two groups. Conclusions Chronic use of proton-pump inhibitors for the duration examined was not associated with significant gastric changes. An interesting finding was that the 4 chronic users of proton-pump inhibitors who had serum gastrin levels above 500 pg/mL also had positive serology for Chagas disease. |
| first_indexed | 2024-04-12T21:30:13Z |
| format | Article |
| id | doaj.art-8e3d45e3e6a74cb9bcf73e7fc8707017 |
| institution | Directory Open Access Journal |
| issn | 1678-4219 |
| language | English |
| last_indexed | 2024-04-12T21:30:13Z |
| publishDate | 2015-03-01 |
| publisher | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) |
| record_format | Article |
| series | Arquivos de Gastroenterologia |
| spelling | doaj.art-8e3d45e3e6a74cb9bcf73e7fc87070172022-12-22T03:16:04ZengInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)Arquivos de Gastroenterologia1678-42192015-03-01521596410.1590/S0004-28032015000100013S0004-28032015000100013ENDOSCOPIC AND HISTOPATHOLOGIC GASTRIC CHANGES IN CHRONIC USERS OF PROTON-PUMP INHIBITORSSílvia Maria Perrone CAMILOÉlia Cláudia de Souza ALMEIDABenito André Silveira MIRANZIJuliano Carvalho SILVARosemary Simões NOMELINIRenata Margarida ETCHEBEHEREBackground Proton-pump inhibitors have been used for at least two decades. They are among the most commonly sold drugs in the world. However, some controversy remains about the indications for their use and the consequences of their prolonged use. Objectives To evaluate and compare the endoscopic and histopathologic gastric changes in chronic users of proton-pump inhibitors to changes in non-users. Methods A prospective study performed at a tertiary Public Hospital involving 105 patients undergoing upper-gastrointestinal endoscopy. Subjects included 81 proton-pump inhibitor users and 24 non-users (control group). Biopsies of the antral-type mucosa, the antral-fundic transition, and the fundus were evaluated by the Sydney System. The presence of erosion or ulceration, lymphatic follicles, reactive gastropathy, and polypoid or epithelial hyperplasia was also determined. Serum levels of gastrin were measured. Results We found two polyps, one in each group, both of which were negative for Helicobacter pylori. There were two cases of parietal cell hyperplasia in users of proton-pump inhibitors. Gastrin was elevated in 28 users of proton-pump inhibitors and in four members of the control group. We did not find statistically significant differences in the endoscopic or histopathologic findings between the two groups. Conclusions Chronic use of proton-pump inhibitors for the duration examined was not associated with significant gastric changes. An interesting finding was that the 4 chronic users of proton-pump inhibitors who had serum gastrin levels above 500 pg/mL also had positive serology for Chagas disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032015000100013&lng=en&tlng=enEndoscopia gastrointestinalInibidores da bomba de prótonsGastrinasDoença de ChagasGastriteHelicobacter pylori |
| spellingShingle | Sílvia Maria Perrone CAMILO Élia Cláudia de Souza ALMEIDA Benito André Silveira MIRANZI Juliano Carvalho SILVA Rosemary Simões NOMELINI Renata Margarida ETCHEBEHERE ENDOSCOPIC AND HISTOPATHOLOGIC GASTRIC CHANGES IN CHRONIC USERS OF PROTON-PUMP INHIBITORS Arquivos de Gastroenterologia Endoscopia gastrointestinal Inibidores da bomba de prótons Gastrinas Doença de Chagas Gastrite Helicobacter pylori |
| title | ENDOSCOPIC AND HISTOPATHOLOGIC GASTRIC CHANGES IN CHRONIC USERS OF PROTON-PUMP INHIBITORS |
| title_full | ENDOSCOPIC AND HISTOPATHOLOGIC GASTRIC CHANGES IN CHRONIC USERS OF PROTON-PUMP INHIBITORS |
| title_fullStr | ENDOSCOPIC AND HISTOPATHOLOGIC GASTRIC CHANGES IN CHRONIC USERS OF PROTON-PUMP INHIBITORS |
| title_full_unstemmed | ENDOSCOPIC AND HISTOPATHOLOGIC GASTRIC CHANGES IN CHRONIC USERS OF PROTON-PUMP INHIBITORS |
| title_short | ENDOSCOPIC AND HISTOPATHOLOGIC GASTRIC CHANGES IN CHRONIC USERS OF PROTON-PUMP INHIBITORS |
| title_sort | endoscopic and histopathologic gastric changes in chronic users of proton pump inhibitors |
| topic | Endoscopia gastrointestinal Inibidores da bomba de prótons Gastrinas Doença de Chagas Gastrite Helicobacter pylori |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032015000100013&lng=en&tlng=en |
| work_keys_str_mv | AT silviamariaperronecamilo endoscopicandhistopathologicgastricchangesinchronicusersofprotonpumpinhibitors AT eliaclaudiadesouzaalmeida endoscopicandhistopathologicgastricchangesinchronicusersofprotonpumpinhibitors AT benitoandresilveiramiranzi endoscopicandhistopathologicgastricchangesinchronicusersofprotonpumpinhibitors AT julianocarvalhosilva endoscopicandhistopathologicgastricchangesinchronicusersofprotonpumpinhibitors AT rosemarysimoesnomelini endoscopicandhistopathologicgastricchangesinchronicusersofprotonpumpinhibitors AT renatamargaridaetchebehere endoscopicandhistopathologicgastricchangesinchronicusersofprotonpumpinhibitors |