Fully implanted battery-free high power platform for chronic spinal and muscular functional electrical stimulation
Abstract Electrical stimulation of the neuromuscular system holds promise for both scientific and therapeutic biomedical applications. Supplying and maintaining the power necessary to drive stimulation chronically is a fundamental challenge in these applications, especially when high voltages or cur...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-43669-2 |
| _version_ | 1797414670349369344 |
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| author | Alex Burton Zhong Wang Dan Song Sam Tran Jessica Hanna Dhrubo Ahmad Jakob Bakall David Clausen Jerry Anderson Roberto Peralta Kirtana Sandepudi Alex Benedetto Ethan Yang Diya Basrai Lee E. Miller Matthew C. Tresch Philipp Gutruf |
| author_facet | Alex Burton Zhong Wang Dan Song Sam Tran Jessica Hanna Dhrubo Ahmad Jakob Bakall David Clausen Jerry Anderson Roberto Peralta Kirtana Sandepudi Alex Benedetto Ethan Yang Diya Basrai Lee E. Miller Matthew C. Tresch Philipp Gutruf |
| author_sort | Alex Burton |
| collection | DOAJ |
| description | Abstract Electrical stimulation of the neuromuscular system holds promise for both scientific and therapeutic biomedical applications. Supplying and maintaining the power necessary to drive stimulation chronically is a fundamental challenge in these applications, especially when high voltages or currents are required. Wireless systems, in which energy is supplied through near field power transfer, could eliminate complications caused by battery packs or external connections, but currently do not provide the harvested power and voltages required for applications such as muscle stimulation. Here, we introduce a passive resonator optimized power transfer design that overcomes these limitations, enabling voltage compliances of ± 20 V and power over 300 mW at device volumes of 0.2 cm2, thereby improving power transfer 500% over previous systems. We show that this improved performance enables multichannel, biphasic, current-controlled operation at clinically relevant voltage and current ranges with digital control and telemetry in freely behaving animals. Preliminary chronic results indicate that implanted devices remain operational over 6 weeks in both intact and spinal cord injured rats and are capable of producing fine control of spinal and muscle stimulation. |
| first_indexed | 2024-03-09T05:36:55Z |
| format | Article |
| id | doaj.art-8e3e0b6525cc484f987973d17ecaef97 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-09T05:36:55Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8e3e0b6525cc484f987973d17ecaef972023-12-03T12:28:09ZengNature PortfolioNature Communications2041-17232023-11-0114111710.1038/s41467-023-43669-2Fully implanted battery-free high power platform for chronic spinal and muscular functional electrical stimulationAlex Burton0Zhong Wang1Dan Song2Sam Tran3Jessica Hanna4Dhrubo Ahmad5Jakob Bakall6David Clausen7Jerry Anderson8Roberto Peralta9Kirtana Sandepudi10Alex Benedetto11Ethan Yang12Diya Basrai13Lee E. Miller14Matthew C. Tresch15Philipp Gutruf16Department of Biomedical Engineering, University of ArizonaDepartment of Neuroscience, Northwestern UniversityDepartment of Biomedical Engineering, Northwestern UniversityDepartment of Neuroscience, Northwestern UniversityDepartment of Biomedical Engineering, University of ArizonaDepartment of Biomedical Engineering, University of ArizonaDepartment of Biomedical Engineering, University of ArizonaDepartment of Biomedical Engineering, University of ArizonaDepartment of Biomedical Engineering, University of ArizonaDepartment of Biomedical Engineering, University of ArizonaDepartment of Biomedical Engineering, Northwestern UniversityInterdepartmental Neuroscience, Northwestern UniversityDepartment of Neuroscience, Northwestern UniversityDepartment of Neuroscience, Northwestern UniversityDepartment of Neuroscience, Northwestern UniversityDepartment of Biomedical Engineering, Northwestern UniversityDepartment of Biomedical Engineering, University of ArizonaAbstract Electrical stimulation of the neuromuscular system holds promise for both scientific and therapeutic biomedical applications. Supplying and maintaining the power necessary to drive stimulation chronically is a fundamental challenge in these applications, especially when high voltages or currents are required. Wireless systems, in which energy is supplied through near field power transfer, could eliminate complications caused by battery packs or external connections, but currently do not provide the harvested power and voltages required for applications such as muscle stimulation. Here, we introduce a passive resonator optimized power transfer design that overcomes these limitations, enabling voltage compliances of ± 20 V and power over 300 mW at device volumes of 0.2 cm2, thereby improving power transfer 500% over previous systems. We show that this improved performance enables multichannel, biphasic, current-controlled operation at clinically relevant voltage and current ranges with digital control and telemetry in freely behaving animals. Preliminary chronic results indicate that implanted devices remain operational over 6 weeks in both intact and spinal cord injured rats and are capable of producing fine control of spinal and muscle stimulation.https://doi.org/10.1038/s41467-023-43669-2 |
| spellingShingle | Alex Burton Zhong Wang Dan Song Sam Tran Jessica Hanna Dhrubo Ahmad Jakob Bakall David Clausen Jerry Anderson Roberto Peralta Kirtana Sandepudi Alex Benedetto Ethan Yang Diya Basrai Lee E. Miller Matthew C. Tresch Philipp Gutruf Fully implanted battery-free high power platform for chronic spinal and muscular functional electrical stimulation Nature Communications |
| title | Fully implanted battery-free high power platform for chronic spinal and muscular functional electrical stimulation |
| title_full | Fully implanted battery-free high power platform for chronic spinal and muscular functional electrical stimulation |
| title_fullStr | Fully implanted battery-free high power platform for chronic spinal and muscular functional electrical stimulation |
| title_full_unstemmed | Fully implanted battery-free high power platform for chronic spinal and muscular functional electrical stimulation |
| title_short | Fully implanted battery-free high power platform for chronic spinal and muscular functional electrical stimulation |
| title_sort | fully implanted battery free high power platform for chronic spinal and muscular functional electrical stimulation |
| url | https://doi.org/10.1038/s41467-023-43669-2 |
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