Kcs1 and Vip1: The Key Enzymes behind Inositol Pyrophosphate Signaling in <i>Saccharomyces cerevisiae</i>
The inositol pyrophosphate pathway, a complex cell signaling network, plays a pivotal role in orchestrating vital cellular processes in the budding yeast, where it regulates cell cycle progression, growth, endocytosis, exocytosis, apoptosis, telomere elongation, ribosome biogenesis, and stress respo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/2/152 |
| _version_ | 1797298769255989248 |
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| author | Larisa Ioana Gogianu Lavinia Liliana Ruta Ileana Cornelia Farcasanu |
| author_facet | Larisa Ioana Gogianu Lavinia Liliana Ruta Ileana Cornelia Farcasanu |
| author_sort | Larisa Ioana Gogianu |
| collection | DOAJ |
| description | The inositol pyrophosphate pathway, a complex cell signaling network, plays a pivotal role in orchestrating vital cellular processes in the budding yeast, where it regulates cell cycle progression, growth, endocytosis, exocytosis, apoptosis, telomere elongation, ribosome biogenesis, and stress responses. This pathway has gained significant attention in pharmacology and medicine due to its role in generating inositol pyrophosphates, which serve as crucial signaling molecules not only in yeast, but also in higher eukaryotes. As targets for therapeutic development, genetic modifications within this pathway hold promise for disease treatment strategies, offering practical applications in biotechnology. The model organism <i>Saccharomyces cerevisiae</i>, renowned for its genetic tractability, has been instrumental in various studies related to the inositol pyrophosphate pathway. This review is focused on the Kcs1 and Vip1, the two enzymes involved in the biosynthesis of inositol pyrophosphate in <i>S. cerevisiae</i>, highlighting their roles in various cell processes, and providing an up-to-date overview of their relationship with phosphate homeostasis. Moreover, the review underscores the potential applications of these findings in the realms of medicine and biotechnology, highlighting the profound implications of comprehending this intricate signaling network. |
| first_indexed | 2024-03-07T22:40:50Z |
| format | Article |
| id | doaj.art-8e3ed36c427147a5a832c58e29e512c8 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-07T22:40:50Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-8e3ed36c427147a5a832c58e29e512c82024-02-23T15:09:14ZengMDPI AGBiomolecules2218-273X2024-01-0114215210.3390/biom14020152Kcs1 and Vip1: The Key Enzymes behind Inositol Pyrophosphate Signaling in <i>Saccharomyces cerevisiae</i>Larisa Ioana Gogianu0Lavinia Liliana Ruta1Ileana Cornelia Farcasanu2Doctoral School of Biology, Faculty of Biology, University of Bucharest, Splaiul Independenței 91-95, 050095 Bucharest, RomaniaFaculty of Chemistry, University of Bucharest, Panduri Road 90-92, 050663 Bucharest, RomaniaDoctoral School of Biology, Faculty of Biology, University of Bucharest, Splaiul Independenței 91-95, 050095 Bucharest, RomaniaThe inositol pyrophosphate pathway, a complex cell signaling network, plays a pivotal role in orchestrating vital cellular processes in the budding yeast, where it regulates cell cycle progression, growth, endocytosis, exocytosis, apoptosis, telomere elongation, ribosome biogenesis, and stress responses. This pathway has gained significant attention in pharmacology and medicine due to its role in generating inositol pyrophosphates, which serve as crucial signaling molecules not only in yeast, but also in higher eukaryotes. As targets for therapeutic development, genetic modifications within this pathway hold promise for disease treatment strategies, offering practical applications in biotechnology. The model organism <i>Saccharomyces cerevisiae</i>, renowned for its genetic tractability, has been instrumental in various studies related to the inositol pyrophosphate pathway. This review is focused on the Kcs1 and Vip1, the two enzymes involved in the biosynthesis of inositol pyrophosphate in <i>S. cerevisiae</i>, highlighting their roles in various cell processes, and providing an up-to-date overview of their relationship with phosphate homeostasis. Moreover, the review underscores the potential applications of these findings in the realms of medicine and biotechnology, highlighting the profound implications of comprehending this intricate signaling network.https://www.mdpi.com/2218-273X/14/2/152inositol pyrophosphateinositol hexakisphosphate kinase<i>Saccharomyces cerevisiae</i>Kcs1Vip1 |
| spellingShingle | Larisa Ioana Gogianu Lavinia Liliana Ruta Ileana Cornelia Farcasanu Kcs1 and Vip1: The Key Enzymes behind Inositol Pyrophosphate Signaling in <i>Saccharomyces cerevisiae</i> Biomolecules inositol pyrophosphate inositol hexakisphosphate kinase <i>Saccharomyces cerevisiae</i> Kcs1 Vip1 |
| title | Kcs1 and Vip1: The Key Enzymes behind Inositol Pyrophosphate Signaling in <i>Saccharomyces cerevisiae</i> |
| title_full | Kcs1 and Vip1: The Key Enzymes behind Inositol Pyrophosphate Signaling in <i>Saccharomyces cerevisiae</i> |
| title_fullStr | Kcs1 and Vip1: The Key Enzymes behind Inositol Pyrophosphate Signaling in <i>Saccharomyces cerevisiae</i> |
| title_full_unstemmed | Kcs1 and Vip1: The Key Enzymes behind Inositol Pyrophosphate Signaling in <i>Saccharomyces cerevisiae</i> |
| title_short | Kcs1 and Vip1: The Key Enzymes behind Inositol Pyrophosphate Signaling in <i>Saccharomyces cerevisiae</i> |
| title_sort | kcs1 and vip1 the key enzymes behind inositol pyrophosphate signaling in i saccharomyces cerevisiae i |
| topic | inositol pyrophosphate inositol hexakisphosphate kinase <i>Saccharomyces cerevisiae</i> Kcs1 Vip1 |
| url | https://www.mdpi.com/2218-273X/14/2/152 |
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