Differences in spine volumetric bone mineral density between grade 1 vertebral fracture and non-fractured participants in the China action on spine and hip status study
PurposeThis study evaluated the prevalence of vertebral fractures (VF) in middle-aged and elderly Chinese men and women and explored the differences in lumbar spine volumetric bone mineral density (vBMD) derived from quantitative CT (QCT) between those with a grade 1 vertebral fracture and non-fract...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1013597/full |
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| author | Yandong Liu Aihong Yu Kai Li Ling Wang Pengju Huang Jian Geng Yong Zhang Yang-yang Duanmu Glen M. Blake Xiaoguang Cheng |
| author_facet | Yandong Liu Aihong Yu Kai Li Ling Wang Pengju Huang Jian Geng Yong Zhang Yang-yang Duanmu Glen M. Blake Xiaoguang Cheng |
| author_sort | Yandong Liu |
| collection | DOAJ |
| description | PurposeThis study evaluated the prevalence of vertebral fractures (VF) in middle-aged and elderly Chinese men and women and explored the differences in lumbar spine volumetric bone mineral density (vBMD) derived from quantitative CT (QCT) between those with a grade 1 vertebral fracture and non-fractured individuals.Materials and methods3,457 participants were enrolled in the China Action on Spine and Hip Status (CASH) study and had upper abdominal CT examinations. Vertebral fractures were identified by Genant’s semi-quantitative method from lateral CT scout views or CT sagittal views. L1-3 vBMD was measured by Mindways QCT Pro v5.0 software. The characteristics of different fracture severity groups were compared using one-way ANOVA, independent-samples t-tests, and Kruskal-Wallis H-tests.Results1267 males (aged 62.77 ± 9.20 years) and 2170 females (aged 61.41 ± 9.01 years) were included in the analysis. In men, the prevalence of VF increased from 14.7% at age<50 years to 23.2% at age ≥70 years, and in women from 5.1% at age<50 years to 33.0% at age ≥70 years. Differences in mean age and vBMD were found between the different fracture grade groups. After age stratification, vBMD differences in men aged < 50 years old disappeared (p = 0.162) but remained in the older age bands. There was no significant difference in mean vBMD between those with multiple mild fractures and those with a single mild fracture.ConclusionIn women, the prevalence of VF increased rapidly after age 50, while it grew more slowly in men. In general, with the exception of men <50 years old, participants with a grade 1 VF had lower vBMD than non-fractured individuals. The majority of women younger than 50 with a grade 1 VF had normal bone mass. We recommend that a vertebral height reduction ratio of <25% be diagnosed as a deformity rather than a fracture in people under the age of 50. The presence of multiple mild fractured vertebrae does not imply lower BMD. |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T01:28:43Z |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-8e3f4ae446ed4318979ceb5f0808a37d2022-12-22T03:53:33ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-10-011310.3389/fendo.2022.10135971013597Differences in spine volumetric bone mineral density between grade 1 vertebral fracture and non-fractured participants in the China action on spine and hip status studyYandong Liu0Aihong Yu1Kai Li2Ling Wang3Pengju Huang4Jian Geng5Yong Zhang6Yang-yang Duanmu7Glen M. Blake8Xiaoguang Cheng9Radiology Department, Peking University Fourth School of Clinical Medicine, Beijing, ChinaRadiology Department, Beijing Anding Hospital Capital Medical University, Beijing, ChinaRadiology Department, Peking University Fourth School of Clinical Medicine, Beijing, ChinaRadiology Department, Peking University Fourth School of Clinical Medicine, Beijing, ChinaRadiology Department, Peking University Fourth School of Clinical Medicine, Beijing, ChinaRadiology Department, Peking University Fourth School of Clinical Medicine, Beijing, ChinaIntervention Department, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaSouth Medical Image Center, The First Affiliated Hospital of University of Science and Technology of China (USTC), Anhui, ChinaSchool of Biomedical Engineering and Imaging Sciences, King’s College London, St Thomas’ Hospital, London, United KingdomRadiology Department, Peking University Fourth School of Clinical Medicine, Beijing, ChinaPurposeThis study evaluated the prevalence of vertebral fractures (VF) in middle-aged and elderly Chinese men and women and explored the differences in lumbar spine volumetric bone mineral density (vBMD) derived from quantitative CT (QCT) between those with a grade 1 vertebral fracture and non-fractured individuals.Materials and methods3,457 participants were enrolled in the China Action on Spine and Hip Status (CASH) study and had upper abdominal CT examinations. Vertebral fractures were identified by Genant’s semi-quantitative method from lateral CT scout views or CT sagittal views. L1-3 vBMD was measured by Mindways QCT Pro v5.0 software. The characteristics of different fracture severity groups were compared using one-way ANOVA, independent-samples t-tests, and Kruskal-Wallis H-tests.Results1267 males (aged 62.77 ± 9.20 years) and 2170 females (aged 61.41 ± 9.01 years) were included in the analysis. In men, the prevalence of VF increased from 14.7% at age<50 years to 23.2% at age ≥70 years, and in women from 5.1% at age<50 years to 33.0% at age ≥70 years. Differences in mean age and vBMD were found between the different fracture grade groups. After age stratification, vBMD differences in men aged < 50 years old disappeared (p = 0.162) but remained in the older age bands. There was no significant difference in mean vBMD between those with multiple mild fractures and those with a single mild fracture.ConclusionIn women, the prevalence of VF increased rapidly after age 50, while it grew more slowly in men. In general, with the exception of men <50 years old, participants with a grade 1 VF had lower vBMD than non-fractured individuals. The majority of women younger than 50 with a grade 1 VF had normal bone mass. We recommend that a vertebral height reduction ratio of <25% be diagnosed as a deformity rather than a fracture in people under the age of 50. The presence of multiple mild fractured vertebrae does not imply lower BMD.https://www.frontiersin.org/articles/10.3389/fendo.2022.1013597/fullvertebral fractureprevalenceGenant’s semi-quantitative methodQCTvolumetric bone mineral density |
| spellingShingle | Yandong Liu Aihong Yu Kai Li Ling Wang Pengju Huang Jian Geng Yong Zhang Yang-yang Duanmu Glen M. Blake Xiaoguang Cheng Differences in spine volumetric bone mineral density between grade 1 vertebral fracture and non-fractured participants in the China action on spine and hip status study Frontiers in Endocrinology vertebral fracture prevalence Genant’s semi-quantitative method QCT volumetric bone mineral density |
| title | Differences in spine volumetric bone mineral density between grade 1 vertebral fracture and non-fractured participants in the China action on spine and hip status study |
| title_full | Differences in spine volumetric bone mineral density between grade 1 vertebral fracture and non-fractured participants in the China action on spine and hip status study |
| title_fullStr | Differences in spine volumetric bone mineral density between grade 1 vertebral fracture and non-fractured participants in the China action on spine and hip status study |
| title_full_unstemmed | Differences in spine volumetric bone mineral density between grade 1 vertebral fracture and non-fractured participants in the China action on spine and hip status study |
| title_short | Differences in spine volumetric bone mineral density between grade 1 vertebral fracture and non-fractured participants in the China action on spine and hip status study |
| title_sort | differences in spine volumetric bone mineral density between grade 1 vertebral fracture and non fractured participants in the china action on spine and hip status study |
| topic | vertebral fracture prevalence Genant’s semi-quantitative method QCT volumetric bone mineral density |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1013597/full |
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