Intraoperative Administration of Adipose Stromal Vascular Fraction Does Not Improve Functional Outcomes in Young Patients with Anterior Cruciate Ligament Reconstruction
Adipose stromal vascular fraction (SVF) has a versatile cellular system for biologically augmented therapies. However, there have been no clinical studies investigating the benefits of the augmentation of anterior cruciate ligament reconstruction (ACLR) with SVF. We conducted a retrospective study i...
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MDPI AG
2022-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/21/6240 |
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| author | Wen-Chin Su Ho-Yi Tuan-Mu Hung-Maan Lee Ting-Yu Hung Kuan-Lin Liu |
| author_facet | Wen-Chin Su Ho-Yi Tuan-Mu Hung-Maan Lee Ting-Yu Hung Kuan-Lin Liu |
| author_sort | Wen-Chin Su |
| collection | DOAJ |
| description | Adipose stromal vascular fraction (SVF) has a versatile cellular system for biologically augmented therapies. However, there have been no clinical studies investigating the benefits of the augmentation of anterior cruciate ligament reconstruction (ACLR) with SVF. We conducted a retrospective study in assessing the effects of intraoperative SVF administration on the functional outcomes in young patients with ACLR. The enrolled patients were divided into the control group (ACLR only) and the SVF group (ACLR with SVF). The functional outcomes in both groups were assessed by the Lysholm knee scoring system, the Tegner activity scale, and the International Knee Documentation Committee (IKDC) subjective evaluation form, and compared at several time points during a 12-month follow-up. We found that the sex distribution and pre-surgery scores were similar in the two groups, whereas the mean age of the SVF group was higher than that of the control group (<i>p</i> = 0.046). The between-group analysis and generalized estimating equation model analysis revealed that, while patients in the SVF group significantly improved all their functional outcomes at 12 months after surgery, this improvement was not significantly different from the results of patients in the control group (Lysholm, <i>p =</i> 0.553; Tegner, <i>p =</i> 0.197; IKDC, <i>p =</i> 0.486). No side effects were observed in either group. We concluded that the intraoperative administration of SVF does not improve or accelerate functional recovery after ACLR in young patients. |
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| language | English |
| last_indexed | 2024-03-09T18:58:46Z |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-8e3f6730f9344ea98c93c888b7c937de2023-11-24T05:14:32ZengMDPI AGJournal of Clinical Medicine2077-03832022-10-011121624010.3390/jcm11216240Intraoperative Administration of Adipose Stromal Vascular Fraction Does Not Improve Functional Outcomes in Young Patients with Anterior Cruciate Ligament ReconstructionWen-Chin Su0Ho-Yi Tuan-Mu1Hung-Maan Lee2Ting-Yu Hung3Kuan-Lin Liu4Department of Orthopedics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, TaiwanDepartment of Physical Therapy, College of Medicine, Tzu Chi University, Hualien 97004, TaiwanDepartment of Orthopedics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, TaiwanSports Medicine Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, TaiwanDepartment of Orthopedics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, TaiwanAdipose stromal vascular fraction (SVF) has a versatile cellular system for biologically augmented therapies. However, there have been no clinical studies investigating the benefits of the augmentation of anterior cruciate ligament reconstruction (ACLR) with SVF. We conducted a retrospective study in assessing the effects of intraoperative SVF administration on the functional outcomes in young patients with ACLR. The enrolled patients were divided into the control group (ACLR only) and the SVF group (ACLR with SVF). The functional outcomes in both groups were assessed by the Lysholm knee scoring system, the Tegner activity scale, and the International Knee Documentation Committee (IKDC) subjective evaluation form, and compared at several time points during a 12-month follow-up. We found that the sex distribution and pre-surgery scores were similar in the two groups, whereas the mean age of the SVF group was higher than that of the control group (<i>p</i> = 0.046). The between-group analysis and generalized estimating equation model analysis revealed that, while patients in the SVF group significantly improved all their functional outcomes at 12 months after surgery, this improvement was not significantly different from the results of patients in the control group (Lysholm, <i>p =</i> 0.553; Tegner, <i>p =</i> 0.197; IKDC, <i>p =</i> 0.486). No side effects were observed in either group. We concluded that the intraoperative administration of SVF does not improve or accelerate functional recovery after ACLR in young patients.https://www.mdpi.com/2077-0383/11/21/6240biologic augmentationadipose stromal vascular fractionfunctional outcomesanterior cruciate ligament reconstruction |
| spellingShingle | Wen-Chin Su Ho-Yi Tuan-Mu Hung-Maan Lee Ting-Yu Hung Kuan-Lin Liu Intraoperative Administration of Adipose Stromal Vascular Fraction Does Not Improve Functional Outcomes in Young Patients with Anterior Cruciate Ligament Reconstruction Journal of Clinical Medicine biologic augmentation adipose stromal vascular fraction functional outcomes anterior cruciate ligament reconstruction |
| title | Intraoperative Administration of Adipose Stromal Vascular Fraction Does Not Improve Functional Outcomes in Young Patients with Anterior Cruciate Ligament Reconstruction |
| title_full | Intraoperative Administration of Adipose Stromal Vascular Fraction Does Not Improve Functional Outcomes in Young Patients with Anterior Cruciate Ligament Reconstruction |
| title_fullStr | Intraoperative Administration of Adipose Stromal Vascular Fraction Does Not Improve Functional Outcomes in Young Patients with Anterior Cruciate Ligament Reconstruction |
| title_full_unstemmed | Intraoperative Administration of Adipose Stromal Vascular Fraction Does Not Improve Functional Outcomes in Young Patients with Anterior Cruciate Ligament Reconstruction |
| title_short | Intraoperative Administration of Adipose Stromal Vascular Fraction Does Not Improve Functional Outcomes in Young Patients with Anterior Cruciate Ligament Reconstruction |
| title_sort | intraoperative administration of adipose stromal vascular fraction does not improve functional outcomes in young patients with anterior cruciate ligament reconstruction |
| topic | biologic augmentation adipose stromal vascular fraction functional outcomes anterior cruciate ligament reconstruction |
| url | https://www.mdpi.com/2077-0383/11/21/6240 |
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