Sex Differences in Metabolic Indices and Chronic Neuroinflammation in Response to Prolonged High-Fat Diet in ApoE4 Knock-In Mice

Sex Differences in Metabolic Indices and Chronic Neuroinflammation in Response to Prolonged High-Fat Diet in ApoE4 Knock-In Mice

Late-onset Alzheimer’s disease (LOAD) likely results from combinations of risk factors that include both genetic predisposition and modifiable lifestyle factors. The E4 allele of apolipoprotein E (ApoE) is the most significant genetic risk factor for LOAD. A Western-pattern diet (WD) has been shown...

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Bibliographic Details
Main Authors: Jennifer M. Mattar, Mark Majchrzak, Jaclyn Iannucci, Sydney Bartman, John K. Robinson, Paula Grammas
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
late-onset Alzheimer’s disease
Western-pattern diet
memory
liver
neuroinflammation
diabetes
Online Access:https://www.mdpi.com/1422-0067/23/7/3921

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