In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels
Animal studies have shown that developmental exposures to polybrominated diphenyl ethers (PBDE) permanently affect blood/liver balance of lipids. No human study has evaluated associations between in utero exposures to persistent organic pollutants (POPs) and later life lipid metabolism. In this pilo...
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MDPI AG
2021-09-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/10/657 |
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| author | Maegan E. Boutot Brian W. Whitcomb Nadia Abdelouahab Andrea A. Baccarelli Amélie Boivin Artuela Caku Virginie Gillet Guillaume Martinez Jean-Charles Pasquier Jiping Zhu Larissa Takser Lindsay St-Cyr Alexander Suvorov |
| author_facet | Maegan E. Boutot Brian W. Whitcomb Nadia Abdelouahab Andrea A. Baccarelli Amélie Boivin Artuela Caku Virginie Gillet Guillaume Martinez Jean-Charles Pasquier Jiping Zhu Larissa Takser Lindsay St-Cyr Alexander Suvorov |
| author_sort | Maegan E. Boutot |
| collection | DOAJ |
| description | Animal studies have shown that developmental exposures to polybrominated diphenyl ethers (PBDE) permanently affect blood/liver balance of lipids. No human study has evaluated associations between in utero exposures to persistent organic pollutants (POPs) and later life lipid metabolism. In this pilot, maternal plasma levels of PBDEs (BDE-47, BDE-99, BDE-100, and BDE-153) and polychlorinated biphenyls (PCB-138, PCB-153, and PCB-180) were determined at delivery in participants of GESTation and Environment (GESTE) cohort. Total cholesterol (TCh), triglycerides (TG), low- and high-density lipoproteins (LDL-C and HDL-C), total lipids (TL), and PBDEs were determined in serum of 147 children at ages 6–7. General linear regression was used to estimate the relationship between maternal POPs and child lipid levels with adjustment for potential confounders, and adjustment for childhood POPs. In utero BDE-99 was associated with lower childhood levels of TG (<i>p</i> = 0.003), and non-significantly with HDL-C (<i>p</i> = 0.06) and TL (<i>p</i> = 0.07). Maternal PCB-138 was associated with lower childhood levels of TG (<i>p</i> = 0.04), LDL-C (<i>p</i> = 0.04), and TL (<i>p</i> = 0.02). Our data indicate that in utero exposures to POPs may be associated with long lasting decrease in circulating lipids in children, suggesting increased lipid accumulation in the liver, a mechanism involved in NAFLD development, consistent with previously reported animal data. |
| first_indexed | 2024-03-10T06:24:08Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T06:24:08Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-8e41a6d212f7408daa0bd30ad9cd914b2023-11-22T19:06:56ZengMDPI AGMetabolites2218-19892021-09-01111065710.3390/metabo11100657In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid LevelsMaegan E. Boutot0Brian W. Whitcomb1Nadia Abdelouahab2Andrea A. Baccarelli3Amélie Boivin4Artuela Caku5Virginie Gillet6Guillaume Martinez7Jean-Charles Pasquier8Jiping Zhu9Larissa Takser10Lindsay St-Cyr11Alexander Suvorov12Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USADepartment of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USADepartment of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, QC J1H 5N4, CanadaDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USADepartment of Pediatrics, Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, QC J1H 5N4, CanadaDepartment of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, QC J1H 5N4, CanadaDepartment of Pediatrics, Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, QC J1H 5N4, CanadaDepartment of Chemistry, Faculty of Sciences, Sherbrooke, QC J1K 2R1, CanadaDepartment of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, QC J1H 5N4, CanadaEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON K1A 0K9, CanadaDepartment of Pediatrics & Department of Psychiatry, Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, QC J1H 5N4, CanadaDepartment of Pediatrics, Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, QC J1H 5N4, CanadaDepartment of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USAAnimal studies have shown that developmental exposures to polybrominated diphenyl ethers (PBDE) permanently affect blood/liver balance of lipids. No human study has evaluated associations between in utero exposures to persistent organic pollutants (POPs) and later life lipid metabolism. In this pilot, maternal plasma levels of PBDEs (BDE-47, BDE-99, BDE-100, and BDE-153) and polychlorinated biphenyls (PCB-138, PCB-153, and PCB-180) were determined at delivery in participants of GESTation and Environment (GESTE) cohort. Total cholesterol (TCh), triglycerides (TG), low- and high-density lipoproteins (LDL-C and HDL-C), total lipids (TL), and PBDEs were determined in serum of 147 children at ages 6–7. General linear regression was used to estimate the relationship between maternal POPs and child lipid levels with adjustment for potential confounders, and adjustment for childhood POPs. In utero BDE-99 was associated with lower childhood levels of TG (<i>p</i> = 0.003), and non-significantly with HDL-C (<i>p</i> = 0.06) and TL (<i>p</i> = 0.07). Maternal PCB-138 was associated with lower childhood levels of TG (<i>p</i> = 0.04), LDL-C (<i>p</i> = 0.04), and TL (<i>p</i> = 0.02). Our data indicate that in utero exposures to POPs may be associated with long lasting decrease in circulating lipids in children, suggesting increased lipid accumulation in the liver, a mechanism involved in NAFLD development, consistent with previously reported animal data.https://www.mdpi.com/2218-1989/11/10/657dyslipidemiafetal programinglipid metabolismNAFLDpersistent organic pollutants |
| spellingShingle | Maegan E. Boutot Brian W. Whitcomb Nadia Abdelouahab Andrea A. Baccarelli Amélie Boivin Artuela Caku Virginie Gillet Guillaume Martinez Jean-Charles Pasquier Jiping Zhu Larissa Takser Lindsay St-Cyr Alexander Suvorov In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels Metabolites dyslipidemia fetal programing lipid metabolism NAFLD persistent organic pollutants |
| title | In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels |
| title_full | In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels |
| title_fullStr | In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels |
| title_full_unstemmed | In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels |
| title_short | In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels |
| title_sort | in utero exposure to persistent organic pollutants and childhood lipid levels |
| topic | dyslipidemia fetal programing lipid metabolism NAFLD persistent organic pollutants |
| url | https://www.mdpi.com/2218-1989/11/10/657 |
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