Mitophagy in the Pathogenesis of Liver Diseases
Autophagy is a catabolic process involving vacuolar sequestration of intracellular components and their targeting to lysosomes for degradation, thus supporting nutrient recycling and energy regeneration. Accumulating evidence indicates that in addition to being a bulk, nonselective degradation mecha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/4/831 |
| _version_ | 1797571886529380352 |
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| author | Po-Yuan Ke |
| author_facet | Po-Yuan Ke |
| author_sort | Po-Yuan Ke |
| collection | DOAJ |
| description | Autophagy is a catabolic process involving vacuolar sequestration of intracellular components and their targeting to lysosomes for degradation, thus supporting nutrient recycling and energy regeneration. Accumulating evidence indicates that in addition to being a bulk, nonselective degradation mechanism, autophagy may selectively eliminate damaged mitochondria to promote mitochondrial turnover, a process termed “mitophagy”. Mitophagy sequesters dysfunctional mitochondria via ubiquitination and cargo receptor recognition and has emerged as an important event in the regulation of liver physiology. Recent studies have shown that mitophagy may participate in the pathogenesis of various liver diseases, such as liver injury, liver steatosis/fatty liver disease, hepatocellular carcinoma, viral hepatitis, and hepatic fibrosis. This review summarizes the current knowledge on the molecular regulations and functions of mitophagy in liver physiology and the roles of mitophagy in the development of liver-related diseases. Furthermore, the therapeutic implications of targeting hepatic mitophagy to design a new strategy to cure liver diseases are discussed. |
| first_indexed | 2024-03-10T20:48:01Z |
| format | Article |
| id | doaj.art-8e41cdc4a6ed4f58b7d90cea8834cf4c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T20:48:01Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8e41cdc4a6ed4f58b7d90cea8834cf4c2023-11-19T20:11:34ZengMDPI AGCells2073-44092020-03-019483110.3390/cells9040831Mitophagy in the Pathogenesis of Liver DiseasesPo-Yuan Ke0Department of Biochemistry & Molecular Biology and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, TaiwanAutophagy is a catabolic process involving vacuolar sequestration of intracellular components and their targeting to lysosomes for degradation, thus supporting nutrient recycling and energy regeneration. Accumulating evidence indicates that in addition to being a bulk, nonselective degradation mechanism, autophagy may selectively eliminate damaged mitochondria to promote mitochondrial turnover, a process termed “mitophagy”. Mitophagy sequesters dysfunctional mitochondria via ubiquitination and cargo receptor recognition and has emerged as an important event in the regulation of liver physiology. Recent studies have shown that mitophagy may participate in the pathogenesis of various liver diseases, such as liver injury, liver steatosis/fatty liver disease, hepatocellular carcinoma, viral hepatitis, and hepatic fibrosis. This review summarizes the current knowledge on the molecular regulations and functions of mitophagy in liver physiology and the roles of mitophagy in the development of liver-related diseases. Furthermore, the therapeutic implications of targeting hepatic mitophagy to design a new strategy to cure liver diseases are discussed.https://www.mdpi.com/2073-4409/9/4/831autophagymitophagyliver diseaseliver injuryhepatitissteatosis |
| spellingShingle | Po-Yuan Ke Mitophagy in the Pathogenesis of Liver Diseases Cells autophagy mitophagy liver disease liver injury hepatitis steatosis |
| title | Mitophagy in the Pathogenesis of Liver Diseases |
| title_full | Mitophagy in the Pathogenesis of Liver Diseases |
| title_fullStr | Mitophagy in the Pathogenesis of Liver Diseases |
| title_full_unstemmed | Mitophagy in the Pathogenesis of Liver Diseases |
| title_short | Mitophagy in the Pathogenesis of Liver Diseases |
| title_sort | mitophagy in the pathogenesis of liver diseases |
| topic | autophagy mitophagy liver disease liver injury hepatitis steatosis |
| url | https://www.mdpi.com/2073-4409/9/4/831 |
| work_keys_str_mv | AT poyuanke mitophagyinthepathogenesisofliverdiseases |