Epigenetics and microRNAs in UGT1As
Abstract UDP-glucuronosyltransferases (UGTs) are the main phase II drug-metabolizing enzymes mediating the most extensive glucuronidation-binding reaction in the human body. The UGT1A family is involved in more than half of glucuronidation reactions. However, significant differences exist in the dis...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-05-01
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| Series: | Human Genomics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40246-021-00331-6 |
| _version_ | 1818002316870025216 |
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| author | Cui-Lan Meng Wei Zhao Dan-Ni Zhong |
| author_facet | Cui-Lan Meng Wei Zhao Dan-Ni Zhong |
| author_sort | Cui-Lan Meng |
| collection | DOAJ |
| description | Abstract UDP-glucuronosyltransferases (UGTs) are the main phase II drug-metabolizing enzymes mediating the most extensive glucuronidation-binding reaction in the human body. The UGT1A family is involved in more than half of glucuronidation reactions. However, significant differences exist in the distribution of UGT1As in vivo and the expression of UGT1As among individuals, and these differences are related to the occurrence of disease and differences in metabolism. In addition to genetic polymorphisms, there is now interest in the contribution of epigenetics and noncoding RNAs (especially miRNAs) to this differential change. Epigenetics regulates UGT1As pretranscriptionally through DNA methylation and histone modification, and miRNAs are considered the key mechanism of posttranscriptional regulation of UGT1As. Both epigenetic inheritance and miRNAs are involved in the differences in sex expression and in vivo distribution of UGT1As. Moreover, epigenetic changes early in life have been shown to affect gene expression throughout life. Here, we review and summarize the current regulatory role of epigenetics in the UGT1A family and discuss the relationship among epigenetics and UGT1A-related diseases and treatment, with references for future research. |
| first_indexed | 2024-04-14T03:45:16Z |
| format | Article |
| id | doaj.art-8e45412ce2fb4a639fdb66d7ebee1643 |
| institution | Directory Open Access Journal |
| issn | 1479-7364 |
| language | English |
| last_indexed | 2024-04-14T03:45:16Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj.art-8e45412ce2fb4a639fdb66d7ebee16432022-12-22T02:14:20ZengBMCHuman Genomics1479-73642021-05-0115111110.1186/s40246-021-00331-6Epigenetics and microRNAs in UGT1AsCui-Lan Meng0Wei Zhao1Dan-Ni Zhong2Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Guangxi Medical UniversityAbstract UDP-glucuronosyltransferases (UGTs) are the main phase II drug-metabolizing enzymes mediating the most extensive glucuronidation-binding reaction in the human body. The UGT1A family is involved in more than half of glucuronidation reactions. However, significant differences exist in the distribution of UGT1As in vivo and the expression of UGT1As among individuals, and these differences are related to the occurrence of disease and differences in metabolism. In addition to genetic polymorphisms, there is now interest in the contribution of epigenetics and noncoding RNAs (especially miRNAs) to this differential change. Epigenetics regulates UGT1As pretranscriptionally through DNA methylation and histone modification, and miRNAs are considered the key mechanism of posttranscriptional regulation of UGT1As. Both epigenetic inheritance and miRNAs are involved in the differences in sex expression and in vivo distribution of UGT1As. Moreover, epigenetic changes early in life have been shown to affect gene expression throughout life. Here, we review and summarize the current regulatory role of epigenetics in the UGT1A family and discuss the relationship among epigenetics and UGT1A-related diseases and treatment, with references for future research.https://doi.org/10.1186/s40246-021-00331-6UDP-glucuronosyltransferase (UGT)1AsEpigeneticsmiRNADrug-metabolizing enzymesPosttranscriptional regulation |
| spellingShingle | Cui-Lan Meng Wei Zhao Dan-Ni Zhong Epigenetics and microRNAs in UGT1As Human Genomics UDP-glucuronosyltransferase (UGT)1As Epigenetics miRNA Drug-metabolizing enzymes Posttranscriptional regulation |
| title | Epigenetics and microRNAs in UGT1As |
| title_full | Epigenetics and microRNAs in UGT1As |
| title_fullStr | Epigenetics and microRNAs in UGT1As |
| title_full_unstemmed | Epigenetics and microRNAs in UGT1As |
| title_short | Epigenetics and microRNAs in UGT1As |
| title_sort | epigenetics and micrornas in ugt1as |
| topic | UDP-glucuronosyltransferase (UGT)1As Epigenetics miRNA Drug-metabolizing enzymes Posttranscriptional regulation |
| url | https://doi.org/10.1186/s40246-021-00331-6 |
| work_keys_str_mv | AT cuilanmeng epigeneticsandmicrornasinugt1as AT weizhao epigeneticsandmicrornasinugt1as AT dannizhong epigeneticsandmicrornasinugt1as |