Circulating cell-free microRNA as biomarkers for screening, diagnosis and monitoring of neurodegenerative diseases and other neurologic pathologies
Many neurodegenerative diseases, such as Alzheimer’s disease, Parkinson disease, vascular and frontotemporal dementias, as well as other chronic neurological pathologies, are characterized by slow development with a long asymptomatic period followed by a stage with mild clinical symptoms. As a cons...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-09-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00150/full |
| _version_ | 1819017787866087424 |
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| author | Kira S Sheinerman Samuil R Umansky |
| author_facet | Kira S Sheinerman Samuil R Umansky |
| author_sort | Kira S Sheinerman |
| collection | DOAJ |
| description | Many neurodegenerative diseases, such as Alzheimer’s disease, Parkinson disease, vascular and frontotemporal dementias, as well as other chronic neurological pathologies, are characterized by slow development with a long asymptomatic period followed by a stage with mild clinical symptoms. As a consequence, these serious pathologies are diagnosed late in the course of a disease, when massive death of neurons has already occurred and effective therapeutic intervention is problematic. Thus, the development of screening tests capable of detecting neurodegenerative diseases during early, preferably asymptomatic, stages is a high unmet need. Since such tests are to be used for screening of large populations, they should be non-invasive and relatively inexpensive. Further, while subjects identified by screening tests can be further tested with more invasive and expensive methods, e.g. analysis of cerebrospinal fluid or imaging techniques, to be of practical utility screening tests should have high sensitivity and specificity. In this review, we discuss advantages and disadvantages of various approaches to developing screening tests based on analysis of circulating cell-free miRNA. Applications of circulating miRNA-based tests for diagnosis of acute and chronic brain pathologies, for research of normal brain aging, and for disease and treatment monitoring are also discussed. |
| first_indexed | 2024-12-21T03:09:05Z |
| format | Article |
| id | doaj.art-8e4b8103ea5947e398ad5a7063067822 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-21T03:09:05Z |
| publishDate | 2013-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-8e4b8103ea5947e398ad5a70630678222022-12-21T19:18:02ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022013-09-01710.3389/fncel.2013.0015061135Circulating cell-free microRNA as biomarkers for screening, diagnosis and monitoring of neurodegenerative diseases and other neurologic pathologiesKira S Sheinerman0Samuil R Umansky1DiamiR, LLCDiamiR, LLCMany neurodegenerative diseases, such as Alzheimer’s disease, Parkinson disease, vascular and frontotemporal dementias, as well as other chronic neurological pathologies, are characterized by slow development with a long asymptomatic period followed by a stage with mild clinical symptoms. As a consequence, these serious pathologies are diagnosed late in the course of a disease, when massive death of neurons has already occurred and effective therapeutic intervention is problematic. Thus, the development of screening tests capable of detecting neurodegenerative diseases during early, preferably asymptomatic, stages is a high unmet need. Since such tests are to be used for screening of large populations, they should be non-invasive and relatively inexpensive. Further, while subjects identified by screening tests can be further tested with more invasive and expensive methods, e.g. analysis of cerebrospinal fluid or imaging techniques, to be of practical utility screening tests should have high sensitivity and specificity. In this review, we discuss advantages and disadvantages of various approaches to developing screening tests based on analysis of circulating cell-free miRNA. Applications of circulating miRNA-based tests for diagnosis of acute and chronic brain pathologies, for research of normal brain aging, and for disease and treatment monitoring are also discussed.http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00150/fullPlasmamiRNAscreeningbiomarkerneurodegenerationAlzheimer’s disease |
| spellingShingle | Kira S Sheinerman Samuil R Umansky Circulating cell-free microRNA as biomarkers for screening, diagnosis and monitoring of neurodegenerative diseases and other neurologic pathologies Frontiers in Cellular Neuroscience Plasma miRNA screening biomarker neurodegeneration Alzheimer’s disease |
| title | Circulating cell-free microRNA as biomarkers for screening, diagnosis and monitoring of neurodegenerative diseases and other neurologic pathologies |
| title_full | Circulating cell-free microRNA as biomarkers for screening, diagnosis and monitoring of neurodegenerative diseases and other neurologic pathologies |
| title_fullStr | Circulating cell-free microRNA as biomarkers for screening, diagnosis and monitoring of neurodegenerative diseases and other neurologic pathologies |
| title_full_unstemmed | Circulating cell-free microRNA as biomarkers for screening, diagnosis and monitoring of neurodegenerative diseases and other neurologic pathologies |
| title_short | Circulating cell-free microRNA as biomarkers for screening, diagnosis and monitoring of neurodegenerative diseases and other neurologic pathologies |
| title_sort | circulating cell free microrna as biomarkers for screening diagnosis and monitoring of neurodegenerative diseases and other neurologic pathologies |
| topic | Plasma miRNA screening biomarker neurodegeneration Alzheimer’s disease |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00150/full |
| work_keys_str_mv | AT kirassheinerman circulatingcellfreemicrornaasbiomarkersforscreeningdiagnosisandmonitoringofneurodegenerativediseasesandotherneurologicpathologies AT samuilrumansky circulatingcellfreemicrornaasbiomarkersforscreeningdiagnosisandmonitoringofneurodegenerativediseasesandotherneurologicpathologies |