Characteristics of P-Type and N-Type Photoelectrochemical Biosensors: A Case Study for Esophageal Cancer Detection
P-type and N-type photoelectrochemical (PEC) biosensors were established in the laboratory to discuss the correlation between characteristic substances and photoactive material properties through the photogenerated charge carrier transport mechanism. Four types of human esophageal cancer cells (ECCs...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/5/1065 |
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| author | Joseph-Hang Leung Hong-Thai Nguyen Shih-Wei Feng Sofya B. Artemkina Vladimir E. Fedorov Shang-Chin Hsieh Hsiang-Chen Wang |
| author_facet | Joseph-Hang Leung Hong-Thai Nguyen Shih-Wei Feng Sofya B. Artemkina Vladimir E. Fedorov Shang-Chin Hsieh Hsiang-Chen Wang |
| author_sort | Joseph-Hang Leung |
| collection | DOAJ |
| description | P-type and N-type photoelectrochemical (PEC) biosensors were established in the laboratory to discuss the correlation between characteristic substances and photoactive material properties through the photogenerated charge carrier transport mechanism. Four types of human esophageal cancer cells (ECCs) were analyzed without requiring additional bias voltage. Photoelectrical characteristics were examined by scanning electron microscopy (SEM), X-ray diffraction (XRD), UV–vis reflectance spectroscopy, and photocurrent response analyses. Results showed that smaller photocurrent was measured in cases with advanced cancer stages. Glutathione (L-glutathione reduced, GSH) and Glutathione disulfide (GSSG) in cancer cells carry out redox reactions during carrier separation, which changes the photocurrent. The sensor can identify ECC stages with a certain level of photoelectrochemical response. The detection error can be optimized by adjusting the number of cells, and the detection time of about 5 min allowed repeated measurement. |
| first_indexed | 2024-03-10T12:06:51Z |
| format | Article |
| id | doaj.art-8e4d89cc1de14ddaaf9d36b30e388b03 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T12:06:51Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-8e4d89cc1de14ddaaf9d36b30e388b032023-11-21T16:29:47ZengMDPI AGNanomaterials2079-49912021-04-01115106510.3390/nano11051065Characteristics of P-Type and N-Type Photoelectrochemical Biosensors: A Case Study for Esophageal Cancer DetectionJoseph-Hang Leung0Hong-Thai Nguyen1Shih-Wei Feng2Sofya B. Artemkina3Vladimir E. Fedorov4Shang-Chin Hsieh5Hsiang-Chen Wang6Department of Radiology, Ditmanson Medical Foundation Chia-yi Christian Hospital, Chia Yi 60002, TaiwanDepartment of Mechanical Engineering, Advanced Institute of Manufacturing with High Tech Innovations (AIM-HI), Center for Innovative Research on Aging Society (CIRAS), National Chung Cheng University, 168, University Rd., Min Hsiung, Chia Yi 62102, TaiwanDepartment of Applied Physics, National University of Kaohsiung, 700 Kaohsiung University Rd., Nanzih District, Kaohsiung 81148, TaiwanNikolaev Institute of Inorganic Chemistry, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, RussiaNikolaev Institute of Inorganic Chemistry, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, RussiaDepartment of Plastic Surgery, Kaohsiung Armed Forces General Hospital, 2, Zhongzheng 1st. Rd., Lingya District, Kaohsiung 80284, TaiwanDepartment of Mechanical Engineering, Advanced Institute of Manufacturing with High Tech Innovations (AIM-HI), Center for Innovative Research on Aging Society (CIRAS), National Chung Cheng University, 168, University Rd., Min Hsiung, Chia Yi 62102, TaiwanP-type and N-type photoelectrochemical (PEC) biosensors were established in the laboratory to discuss the correlation between characteristic substances and photoactive material properties through the photogenerated charge carrier transport mechanism. Four types of human esophageal cancer cells (ECCs) were analyzed without requiring additional bias voltage. Photoelectrical characteristics were examined by scanning electron microscopy (SEM), X-ray diffraction (XRD), UV–vis reflectance spectroscopy, and photocurrent response analyses. Results showed that smaller photocurrent was measured in cases with advanced cancer stages. Glutathione (L-glutathione reduced, GSH) and Glutathione disulfide (GSSG) in cancer cells carry out redox reactions during carrier separation, which changes the photocurrent. The sensor can identify ECC stages with a certain level of photoelectrochemical response. The detection error can be optimized by adjusting the number of cells, and the detection time of about 5 min allowed repeated measurement.https://www.mdpi.com/2079-4991/11/5/1065esophageal squamous cell carcinomatransient photocurrentphotoelectrochemical biosensorglutathione |
| spellingShingle | Joseph-Hang Leung Hong-Thai Nguyen Shih-Wei Feng Sofya B. Artemkina Vladimir E. Fedorov Shang-Chin Hsieh Hsiang-Chen Wang Characteristics of P-Type and N-Type Photoelectrochemical Biosensors: A Case Study for Esophageal Cancer Detection Nanomaterials esophageal squamous cell carcinoma transient photocurrent photoelectrochemical biosensor glutathione |
| title | Characteristics of P-Type and N-Type Photoelectrochemical Biosensors: A Case Study for Esophageal Cancer Detection |
| title_full | Characteristics of P-Type and N-Type Photoelectrochemical Biosensors: A Case Study for Esophageal Cancer Detection |
| title_fullStr | Characteristics of P-Type and N-Type Photoelectrochemical Biosensors: A Case Study for Esophageal Cancer Detection |
| title_full_unstemmed | Characteristics of P-Type and N-Type Photoelectrochemical Biosensors: A Case Study for Esophageal Cancer Detection |
| title_short | Characteristics of P-Type and N-Type Photoelectrochemical Biosensors: A Case Study for Esophageal Cancer Detection |
| title_sort | characteristics of p type and n type photoelectrochemical biosensors a case study for esophageal cancer detection |
| topic | esophageal squamous cell carcinoma transient photocurrent photoelectrochemical biosensor glutathione |
| url | https://www.mdpi.com/2079-4991/11/5/1065 |
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