A 6-month exercise intervention clinical trial in women: effects of physical activity on multi-omics biomarkers and health during the first wave of COVID-19 in Korea
Abstract Background Coronavirus disease 2019 (COVID-19) was first reported in December 2019 and the first case in Korea was confirmed on January 20, 2020. Due to the absence of therapeutic agents and vaccines, the Korean government implemented social distancing on February 29, 2020. This study aimed...
| Những tác giả chính: | , , , , , , , , , |
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| Định dạng: | Bài viết |
| Ngôn ngữ: | English |
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BMC
2024-01-01
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| Loạt: | BMC Sports Science, Medicine and Rehabilitation |
| Những chủ đề: | |
| Truy cập trực tuyến: | https://doi.org/10.1186/s13102-024-00824-6 |
| _version_ | 1827326590162305024 |
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| author | JooYong Park Jaemyung Kim Jihyun Kang Jaesung Choi Ji-Eun Kim Kyung-Joon Min Seong-Woo Choi Joo-Youn Cho Miyoung Lee Ji-Yeob Choi |
| author_facet | JooYong Park Jaemyung Kim Jihyun Kang Jaesung Choi Ji-Eun Kim Kyung-Joon Min Seong-Woo Choi Joo-Youn Cho Miyoung Lee Ji-Yeob Choi |
| author_sort | JooYong Park |
| collection | DOAJ |
| description | Abstract Background Coronavirus disease 2019 (COVID-19) was first reported in December 2019 and the first case in Korea was confirmed on January 20, 2020. Due to the absence of therapeutic agents and vaccines, the Korean government implemented social distancing on February 29, 2020. This study aimed to examine the effect of physical activity (PA) on health through changes in multi-omics biomarkers with a 6-month of exercise intervention during the first wave of COVID-19 in Korea. Methods Twenty-seven healthy middle-aged women were recruited and 14 subjects completed the exercise intervention. The mean age (± SD) was 46.3 (± 5.33) and the mean BMI (± SD) was 24.9 (± 3.88). A total of three blood and stool samples were collected at enrollment, after period 1, and after period 2 (3-month intervals). The amount of PA was measured with an accelerometer and by questionnaire. Clinical variables were used, including blood pressure, grip strength, flexibility, and blood glucose levels and lipid markers obtained from laboratory tests. The concentration of blood metabolites was measured by targeted metabolomics. Fecal microbiome data were obtained by 16 S rRNA gene amplicon sequencing. Results During the second half period (period 2), Coronavirus disease 2019 occurred and spread out in Korea, and PA decreased compared with the first half period (period 1) (185.9 ± 168.73 min/week to 102.5 ± 82.30 min/week; p = 0.0101). Blood pressure, hemoglobin A1c (HbA1c), and low-density lipoprotein cholesterol (LDL-C) decreased in period 1 (p < 0.05) and tended to increase again during period 2 (p < 0.05). Forty metabolites were changed significantly during period 1 (FDR p < 0.05), and we found that 6 of them were correlated with changes in blood pressure, HbA1c, and LDL-C via network analysis. Conclusions Our results may suggest that exercise improves health through changes in biomarkers at multi-omics levels. However, reduced PA due to COVID-19 can adversely affect health, emphasizing the necessity for sustained exercise and support for home-based fitness to maintain health. Trial Registration The trial is retrospectively registered on ClinicalTrials.gov (NCT05927675; June 30, 2023). |
| first_indexed | 2024-03-07T14:46:50Z |
| format | Article |
| id | doaj.art-8e504c6fd4094e859609f3d030f1cea2 |
| institution | Directory Open Access Journal |
| issn | 2052-1847 |
| language | English |
| last_indexed | 2024-03-07T14:46:50Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Sports Science, Medicine and Rehabilitation |
| spelling | doaj.art-8e504c6fd4094e859609f3d030f1cea22024-03-05T19:55:10ZengBMCBMC Sports Science, Medicine and Rehabilitation2052-18472024-01-0116111310.1186/s13102-024-00824-6A 6-month exercise intervention clinical trial in women: effects of physical activity on multi-omics biomarkers and health during the first wave of COVID-19 in KoreaJooYong Park0Jaemyung Kim1Jihyun Kang2Jaesung Choi3Ji-Eun Kim4Kyung-Joon Min5Seong-Woo Choi6Joo-Youn Cho7Miyoung Lee8Ji-Yeob Choi9Department of Big Data Medical Convergence, Eulji UniversitySchool of Biological and Population Health Sciences, Oregon State UniversityDepartment of Biomedical Sciences Graduate School, Seoul National UniversityInstitute of Health Policy and Management, Seoul National University Medical Research CenterDepartment of Biomedical Sciences Graduate School, Seoul National UniversityDISPIS, CorporateDISPIS, CorporateDepartment of Biomedical Sciences Graduate School, Seoul National UniversityCollege of Physical Education and Sport Science, Kookmin UniversityDepartment of Biomedical Sciences Graduate School, Seoul National UniversityAbstract Background Coronavirus disease 2019 (COVID-19) was first reported in December 2019 and the first case in Korea was confirmed on January 20, 2020. Due to the absence of therapeutic agents and vaccines, the Korean government implemented social distancing on February 29, 2020. This study aimed to examine the effect of physical activity (PA) on health through changes in multi-omics biomarkers with a 6-month of exercise intervention during the first wave of COVID-19 in Korea. Methods Twenty-seven healthy middle-aged women were recruited and 14 subjects completed the exercise intervention. The mean age (± SD) was 46.3 (± 5.33) and the mean BMI (± SD) was 24.9 (± 3.88). A total of three blood and stool samples were collected at enrollment, after period 1, and after period 2 (3-month intervals). The amount of PA was measured with an accelerometer and by questionnaire. Clinical variables were used, including blood pressure, grip strength, flexibility, and blood glucose levels and lipid markers obtained from laboratory tests. The concentration of blood metabolites was measured by targeted metabolomics. Fecal microbiome data were obtained by 16 S rRNA gene amplicon sequencing. Results During the second half period (period 2), Coronavirus disease 2019 occurred and spread out in Korea, and PA decreased compared with the first half period (period 1) (185.9 ± 168.73 min/week to 102.5 ± 82.30 min/week; p = 0.0101). Blood pressure, hemoglobin A1c (HbA1c), and low-density lipoprotein cholesterol (LDL-C) decreased in period 1 (p < 0.05) and tended to increase again during period 2 (p < 0.05). Forty metabolites were changed significantly during period 1 (FDR p < 0.05), and we found that 6 of them were correlated with changes in blood pressure, HbA1c, and LDL-C via network analysis. Conclusions Our results may suggest that exercise improves health through changes in biomarkers at multi-omics levels. However, reduced PA due to COVID-19 can adversely affect health, emphasizing the necessity for sustained exercise and support for home-based fitness to maintain health. Trial Registration The trial is retrospectively registered on ClinicalTrials.gov (NCT05927675; June 30, 2023).https://doi.org/10.1186/s13102-024-00824-6SARS-CoV-2ExerciseBiomarkersMetabolomeMicrobiota |
| spellingShingle | JooYong Park Jaemyung Kim Jihyun Kang Jaesung Choi Ji-Eun Kim Kyung-Joon Min Seong-Woo Choi Joo-Youn Cho Miyoung Lee Ji-Yeob Choi A 6-month exercise intervention clinical trial in women: effects of physical activity on multi-omics biomarkers and health during the first wave of COVID-19 in Korea BMC Sports Science, Medicine and Rehabilitation SARS-CoV-2 Exercise Biomarkers Metabolome Microbiota |
| title | A 6-month exercise intervention clinical trial in women: effects of physical activity on multi-omics biomarkers and health during the first wave of COVID-19 in Korea |
| title_full | A 6-month exercise intervention clinical trial in women: effects of physical activity on multi-omics biomarkers and health during the first wave of COVID-19 in Korea |
| title_fullStr | A 6-month exercise intervention clinical trial in women: effects of physical activity on multi-omics biomarkers and health during the first wave of COVID-19 in Korea |
| title_full_unstemmed | A 6-month exercise intervention clinical trial in women: effects of physical activity on multi-omics biomarkers and health during the first wave of COVID-19 in Korea |
| title_short | A 6-month exercise intervention clinical trial in women: effects of physical activity on multi-omics biomarkers and health during the first wave of COVID-19 in Korea |
| title_sort | 6 month exercise intervention clinical trial in women effects of physical activity on multi omics biomarkers and health during the first wave of covid 19 in korea |
| topic | SARS-CoV-2 Exercise Biomarkers Metabolome Microbiota |
| url | https://doi.org/10.1186/s13102-024-00824-6 |
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