Targeting Neuropilin-1 with Nanobodies Reduces Colorectal Carcinoma Development

Targeting Neuropilin-1 with Nanobodies Reduces Colorectal Carcinoma Development

Neuropilin-1 (NRP-1) is a co-receptor for semaphorins and vascular endothelial growth factor (VEGF) family members that can be expressed on cancer cells and tumor-infiltrating myeloid, endothelial and lymphoid cells. It has been linked to a tumor-promoting environment upon interaction with semaphori...

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Bibliographic Details
Main Authors: Yannick De Vlaeminck, Stefano Bonelli, Robin Maximilian Awad, Maarten Dewilde, Sabrina Rizzolio, Quentin Lecocq, Evangelia Bolli, Ana Rita Santos, Damya Laoui, Steve Schoonooghe, Luca Tamagnone, Cleo Goyvaerts, Massimiliano Mazzone, Karine Breckpot, Jo A. Van Ginderachter
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
neuropilin-1
nanobody
single-domain antibody fragment
cancer
immune checkpoint
immunotherapy
Online Access:https://www.mdpi.com/2072-6694/12/12/3582

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