Prognostic Markers of Microinvasive Breast Carcinoma: A Systematic Review and Meta-Analysis
(1) Background: The prognostic factors of microinvasive (≤1 mm) breast carcinoma are not completely clear. The aim of this study was to perform a systematic review and meta-analysis to clarify these factors. (2) Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/11/3007 |
| _version_ | 1797597807256797184 |
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| author | Andrea Ambrosini-Spaltro Francesco Di Donato Luca Saragoni Gábor Cserni Emad Rakha Maria Pia Foschini |
| author_facet | Andrea Ambrosini-Spaltro Francesco Di Donato Luca Saragoni Gábor Cserni Emad Rakha Maria Pia Foschini |
| author_sort | Andrea Ambrosini-Spaltro |
| collection | DOAJ |
| description | (1) Background: The prognostic factors of microinvasive (≤1 mm) breast carcinoma are not completely clear. The aim of this study was to perform a systematic review and meta-analysis to clarify these factors. (2) Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology was followed. Two databases were interrogated, PubMed and Embase, and papers in English were included to address this question. The selected studies were those that reported on female patients affected by microinvasive carcinoma, and on prognostic factors with a hazard ratio (HR) for disease-free survival (DFS) and overall survival (OS). (3) Results: In total, 618 records were identified. After removing duplicates (166), identification, and screening (336 by title and abstract alone, 116 by full text and eventual supplementary material), 5 papers were selected. Seven different meta-analyses were conducted in this study, all referring to DFS, analyzing the following prognostic factors: estrogen receptor, progesterone receptor, HER2 status, multifocality and grade of microinvasion, patient’s age, and lymph node status. Only lymph node status was associated with prognosis and DFS (total number of cases: 1528; Z = 1.94; <i>p</i> = 0.05). The other factors examined did not significantly affect prognosis (<i>p</i> > 0.05). (4) Conclusions: Positive lymph node status significantly worsens prognosis in patients with microinvasive breast carcinoma. |
| first_indexed | 2024-03-11T03:10:40Z |
| format | Article |
| id | doaj.art-8e51b429493649be8b9a16d80ced2910 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T03:10:40Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8e51b429493649be8b9a16d80ced29102023-11-18T07:39:28ZengMDPI AGCancers2072-66942023-05-011511300710.3390/cancers15113007Prognostic Markers of Microinvasive Breast Carcinoma: A Systematic Review and Meta-AnalysisAndrea Ambrosini-Spaltro0Francesco Di Donato1Luca Saragoni2Gábor Cserni3Emad Rakha4Maria Pia Foschini5Pathology Unit, Morgani-Pierantoni Hospital, AUSL Romagna, 47121 Forlì, ItalyPathology Unit, Santa Maria delle Croci Hospital, AUSL Romagna, 48121 Ravenna, ItalyPathology Unit, Santa Maria delle Croci Hospital, AUSL Romagna, 48121 Ravenna, ItalyDepartment of Pathology, Bács-Kiskun County Teaching Hospital, 6000 Kecskemét, HungaryHistopathology Department, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UKUnit of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bellaria Hospital, 40139 Bologna, Italy(1) Background: The prognostic factors of microinvasive (≤1 mm) breast carcinoma are not completely clear. The aim of this study was to perform a systematic review and meta-analysis to clarify these factors. (2) Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology was followed. Two databases were interrogated, PubMed and Embase, and papers in English were included to address this question. The selected studies were those that reported on female patients affected by microinvasive carcinoma, and on prognostic factors with a hazard ratio (HR) for disease-free survival (DFS) and overall survival (OS). (3) Results: In total, 618 records were identified. After removing duplicates (166), identification, and screening (336 by title and abstract alone, 116 by full text and eventual supplementary material), 5 papers were selected. Seven different meta-analyses were conducted in this study, all referring to DFS, analyzing the following prognostic factors: estrogen receptor, progesterone receptor, HER2 status, multifocality and grade of microinvasion, patient’s age, and lymph node status. Only lymph node status was associated with prognosis and DFS (total number of cases: 1528; Z = 1.94; <i>p</i> = 0.05). The other factors examined did not significantly affect prognosis (<i>p</i> > 0.05). (4) Conclusions: Positive lymph node status significantly worsens prognosis in patients with microinvasive breast carcinoma.https://www.mdpi.com/2072-6694/15/11/3007microinvasivebreastcarcinomaprognostic factorsystematic reviewmeta-analysis |
| spellingShingle | Andrea Ambrosini-Spaltro Francesco Di Donato Luca Saragoni Gábor Cserni Emad Rakha Maria Pia Foschini Prognostic Markers of Microinvasive Breast Carcinoma: A Systematic Review and Meta-Analysis Cancers microinvasive breast carcinoma prognostic factor systematic review meta-analysis |
| title | Prognostic Markers of Microinvasive Breast Carcinoma: A Systematic Review and Meta-Analysis |
| title_full | Prognostic Markers of Microinvasive Breast Carcinoma: A Systematic Review and Meta-Analysis |
| title_fullStr | Prognostic Markers of Microinvasive Breast Carcinoma: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Prognostic Markers of Microinvasive Breast Carcinoma: A Systematic Review and Meta-Analysis |
| title_short | Prognostic Markers of Microinvasive Breast Carcinoma: A Systematic Review and Meta-Analysis |
| title_sort | prognostic markers of microinvasive breast carcinoma a systematic review and meta analysis |
| topic | microinvasive breast carcinoma prognostic factor systematic review meta-analysis |
| url | https://www.mdpi.com/2072-6694/15/11/3007 |
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