CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder

CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder

IntroductionDNA methylation (DNAm), an epigenetic mechanism, has been associated with opioid use disorder (OUD) in preclinical and human studies. However, most of the studies have focused on DNAm at CpG sites. DNAm at non-CpG sites (mCpHs, where H indicates A, T, or C) has been recently shown to hav...

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Main Authors: Sheila T. Nagamatsu, Gregory Rompala, Yasmin L. Hurd, Diana L. Núñez-Rios, Janitza L. Montalvo-Ortiz, Traumatic Stress Brain Research Group, Victor E. Alvarez, David Benedek, Alicia Che, Dianne A. Cruz, David A. Davis, Matthew J. Girgenti, Ellen Hoffman, Paul E. Holtzheimer, Bertrand R. Huber, Alfred Kaye, John H. Krystal, Adam T. Labadorf, Terence M. Keane, Mark W. Logue, Ann McKee, Brian Marx, Deborah Mash, Mark W. Miller, Crystal Noller, JM-O, William K. Scott, Paula Schnurr, Thor Stein, Robert Ursano, Douglas E. Williamson, Erika J. Wolf, Keith A. Young
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Psychiatry
Subjects:
opioid
methylation
non-CpG site
postmortem human brain
orbitofrontal cortex
epigenetic
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1078894/full

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