The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release
Hypothalamic magnocellular neurons release vasopressin and oxytocin not only from their axon terminals into the blood, but also from their somata and dendrites into the extracellular space of the brain, and this can be regulated independently. Differential release of neurotransmitters from different...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-07-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00261/full |
| _version_ | 1818839723461836800 |
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| author | Vicky A. Tobin Gareth eLeng Mike eLudwig |
| author_facet | Vicky A. Tobin Gareth eLeng Mike eLudwig |
| author_sort | Vicky A. Tobin |
| collection | DOAJ |
| description | Hypothalamic magnocellular neurons release vasopressin and oxytocin not only from their axon terminals into the blood, but also from their somata and dendrites into the extracellular space of the brain, and this can be regulated independently. Differential release of neurotransmitters from different compartments of a single neuron requires subtle regulatory mechanisms. Somato-dendritic, but not axon terminal release can be modulated by changes in intracellular calcium concentration ([Ca2+]) by release of calcium from intracellular stores, resulting in priming of dendritic pools for activity-dependent release. This review focuses on our current understanding of the mechanisms of priming and the roles of actin remodelling, voltage-operated calcium channels and SNARE proteins in the regulation somato-dendritic and axon terminal peptide release. |
| first_indexed | 2024-12-19T03:58:49Z |
| format | Article |
| id | doaj.art-8e53a0e3ed8349229a72ea7f89733f98 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-19T03:58:49Z |
| publishDate | 2012-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-8e53a0e3ed8349229a72ea7f89733f982022-12-21T20:36:45ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2012-07-01310.3389/fphys.2012.0026129203The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin releaseVicky A. Tobin0Gareth eLeng1Mike eLudwig2University of EdinburghUniversity of EdinburghUniversity of EdinburghHypothalamic magnocellular neurons release vasopressin and oxytocin not only from their axon terminals into the blood, but also from their somata and dendrites into the extracellular space of the brain, and this can be regulated independently. Differential release of neurotransmitters from different compartments of a single neuron requires subtle regulatory mechanisms. Somato-dendritic, but not axon terminal release can be modulated by changes in intracellular calcium concentration ([Ca2+]) by release of calcium from intracellular stores, resulting in priming of dendritic pools for activity-dependent release. This review focuses on our current understanding of the mechanisms of priming and the roles of actin remodelling, voltage-operated calcium channels and SNARE proteins in the regulation somato-dendritic and axon terminal peptide release.http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00261/fullExocytosisHypothalamusNeuropeptidesOxytocinvasopressinposterior pituitary |
| spellingShingle | Vicky A. Tobin Gareth eLeng Mike eLudwig The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release Frontiers in Physiology Exocytosis Hypothalamus Neuropeptides Oxytocin vasopressin posterior pituitary |
| title | The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release |
| title_full | The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release |
| title_fullStr | The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release |
| title_full_unstemmed | The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release |
| title_short | The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release |
| title_sort | involvement of actin calcium channels and exocytosis proteins in somato dendritic oxytocin and vasopressin release |
| topic | Exocytosis Hypothalamus Neuropeptides Oxytocin vasopressin posterior pituitary |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00261/full |
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