The role of tumor neogenesis pipelines in tumor progression and their therapeutic potential
Abstract Pipeline formation between tumor cells and the tumor microenvironment (TME) is a key event leading to tumor progression. These pipelines include blood vessels, lymphatics, and membranous vessels (the former two can be collectively referred to as vasculature). Pipeline regeneration is a feat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.4979 |
| _version_ | 1811176395331600384 |
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| author | Zhanqi Fu Yuan Yuan |
| author_facet | Zhanqi Fu Yuan Yuan |
| author_sort | Zhanqi Fu |
| collection | DOAJ |
| description | Abstract Pipeline formation between tumor cells and the tumor microenvironment (TME) is a key event leading to tumor progression. These pipelines include blood vessels, lymphatics, and membranous vessels (the former two can be collectively referred to as vasculature). Pipeline regeneration is a feature of all solid tumors; it delivers nutrients to tumors and promotes tumor invasion and metastasis such that cancer cells grow rapidly, escape unfavorable TME, spread to secondary sites, generate tumor drug resistance, and promote postoperative tumor recurrence. Novel tumor therapy strategies must exploit the molecular mechanisms underpinning these pipelines to facilitate more targeted drug therapies. In this review, pipeline generation, influencing factors, pipeline functions during tumor progression, and pipeline potential as drug targets are systematically summarized. |
| first_indexed | 2024-04-10T19:51:52Z |
| format | Article |
| id | doaj.art-8e55061eafb546959b81ba6cd56d8afc |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-10T19:51:52Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-8e55061eafb546959b81ba6cd56d8afc2023-01-28T05:30:04ZengWileyCancer Medicine2045-76342023-01-011221558157110.1002/cam4.4979The role of tumor neogenesis pipelines in tumor progression and their therapeutic potentialZhanqi Fu0Yuan Yuan1Tumor Etiology and Screening Department of Cancer Institute and General Surgery The First Hospital of China Medical University Shenyang ChinaTumor Etiology and Screening Department of Cancer Institute and General Surgery The First Hospital of China Medical University Shenyang ChinaAbstract Pipeline formation between tumor cells and the tumor microenvironment (TME) is a key event leading to tumor progression. These pipelines include blood vessels, lymphatics, and membranous vessels (the former two can be collectively referred to as vasculature). Pipeline regeneration is a feature of all solid tumors; it delivers nutrients to tumors and promotes tumor invasion and metastasis such that cancer cells grow rapidly, escape unfavorable TME, spread to secondary sites, generate tumor drug resistance, and promote postoperative tumor recurrence. Novel tumor therapy strategies must exploit the molecular mechanisms underpinning these pipelines to facilitate more targeted drug therapies. In this review, pipeline generation, influencing factors, pipeline functions during tumor progression, and pipeline potential as drug targets are systematically summarized.https://doi.org/10.1002/cam4.4979neogenesis pipelinetherapeutic targettumortumor invasiontumor progression |
| spellingShingle | Zhanqi Fu Yuan Yuan The role of tumor neogenesis pipelines in tumor progression and their therapeutic potential Cancer Medicine neogenesis pipeline therapeutic target tumor tumor invasion tumor progression |
| title | The role of tumor neogenesis pipelines in tumor progression and their therapeutic potential |
| title_full | The role of tumor neogenesis pipelines in tumor progression and their therapeutic potential |
| title_fullStr | The role of tumor neogenesis pipelines in tumor progression and their therapeutic potential |
| title_full_unstemmed | The role of tumor neogenesis pipelines in tumor progression and their therapeutic potential |
| title_short | The role of tumor neogenesis pipelines in tumor progression and their therapeutic potential |
| title_sort | role of tumor neogenesis pipelines in tumor progression and their therapeutic potential |
| topic | neogenesis pipeline therapeutic target tumor tumor invasion tumor progression |
| url | https://doi.org/10.1002/cam4.4979 |
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