Erucin Exerts Cardioprotective Effects on Ischemia/Reperfusion Injury through the Modulation of mitoKATP Channels
Modulation of mitochondrial K channels represents a pharmacological strategy to promote cardioprotective effects. Isothiocyanates emerge as molecules capable of releasing hydrogen sulfide (H<sub>2</sub>S), an endogenous pleiotropic gasotransmitter responsible for anti-ischemic cardioprot...
Main Authors: | Lorenzo Flori, Rosangela Montanaro, Eleonora Pagnotta, Luisa Ugolini, Laura Righetti, Alma Martelli, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Vincenzo Brancaleone, Lara Testai, Vincenzo Calderone |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-12-01
|
Series: | Biomedicines |
Subjects: | |
Online Access: | https://www.mdpi.com/2227-9059/11/12/3281 |
Similar Items
-
The H<sub>2</sub>S-Donor Erucin Exhibits Protective Effects against Vascular Inflammation in Human Endothelial and Smooth Muscle Cells
by: Alma Martelli, et al.
Published: (2021-06-01) -
Anti-Inflammatory Effect of the Natural H<sub>2</sub>S-Donor Erucin in Vascular Endothelium
by: Valerio Ciccone, et al.
Published: (2022-12-01) -
Anti-Proliferative Properties of the Novel Hybrid Drug Met-ITC, Composed of the Native Drug Metformin with the Addition of an Isothiocyanate H<sub>2</sub>S Donor Moiety, in Different Cancer Cell Lines
by: Valentina Citi, et al.
Published: (2023-11-01) -
Overexpression of a Short Sulfonylurea Splice Variant Increases Cardiac Glucose Uptake and Uncouples Mitochondria by Regulating ROMK Activity
by: Sarah K. El-Meanawy, et al.
Published: (2023-04-01) -
Pharmacological Characterization of a Recombinant Mitochondrial ROMK2 Potassium Channel Expressed in Bacteria and Reconstituted in Planar Lipid Bilayers
by: Milena Krajewska, et al.
Published: (2023-03-01)