Enhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer
Abstract Ferroptosis provides an opportunity to overcome the cancer cell therapeutic resistance and modulate the immune system. Here an interaction between ferroptosis of cancer cells and natural killer (NK) cells was investigated with a clinical grade iron oxide nanoparticle (ferumoxytol) for poten...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-09-01
|
| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01635-y |
| _version_ | 1811200828348825600 |
|---|---|
| author | Kwang-Soo Kim Bongseo Choi Hyunjun Choi Min Jun Ko Dong-Hwan Kim Dong-Hyun Kim |
| author_facet | Kwang-Soo Kim Bongseo Choi Hyunjun Choi Min Jun Ko Dong-Hwan Kim Dong-Hyun Kim |
| author_sort | Kwang-Soo Kim |
| collection | DOAJ |
| description | Abstract Ferroptosis provides an opportunity to overcome the cancer cell therapeutic resistance and modulate the immune system. Here an interaction between ferroptosis of cancer cells and natural killer (NK) cells was investigated with a clinical grade iron oxide nanoparticle (ferumoxytol) for potential synergistic anti-cancer effect of ferroptosis and NK cell therapy in prostate cancer. When ferumoxytol mediated ferroptosis of cancer cells was combined with NK cells, the NK cells’ cytotoxic function was increased. Observed ferroptosis mediated NK cell activation was also confirmed with IFN-γ secretion and lytic degranulation. Upregulation of ULBPs, which is one of the ligands for NK cell activating receptor NKG2D, was observed in the co-treatment of ferumoxytol mediated ferroptosis and NK cells. Additionally, HMGB1 and PD-L1 expression of cancer cells were observed in the treatment of ferroptosis + NK cells. Finally, in vivo therapeutic efficacy of ferumoxytol mediated ferroptosis and NK cell therapy was observed with significant tumor volume regression in a prostate cancer mice model. These results suggest that the NK cells’ function can be enhanced with ferumoxytol mediated ferroptosis. |
| first_indexed | 2024-04-12T02:11:26Z |
| format | Article |
| id | doaj.art-8e57f2b00aed4899ab9645a8db81fd34 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-12T02:11:26Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-8e57f2b00aed4899ab9645a8db81fd342022-12-22T03:52:24ZengBMCJournal of Nanobiotechnology1477-31552022-09-0120111210.1186/s12951-022-01635-yEnhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancerKwang-Soo Kim0Bongseo Choi1Hyunjun Choi2Min Jun Ko3Dong-Hwan Kim4Dong-Hyun Kim5Department of Radiology, Feinberg School of Medicine, Northwestern UniversityDepartment of Radiology, Feinberg School of Medicine, Northwestern UniversityDepartment of Radiology, Feinberg School of Medicine, Northwestern UniversityDepartment of Radiology, Feinberg School of Medicine, Northwestern UniversitySchool of Chemical Engineering, Sungkyunkwan University (SKKU)Department of Radiology, Feinberg School of Medicine, Northwestern UniversityAbstract Ferroptosis provides an opportunity to overcome the cancer cell therapeutic resistance and modulate the immune system. Here an interaction between ferroptosis of cancer cells and natural killer (NK) cells was investigated with a clinical grade iron oxide nanoparticle (ferumoxytol) for potential synergistic anti-cancer effect of ferroptosis and NK cell therapy in prostate cancer. When ferumoxytol mediated ferroptosis of cancer cells was combined with NK cells, the NK cells’ cytotoxic function was increased. Observed ferroptosis mediated NK cell activation was also confirmed with IFN-γ secretion and lytic degranulation. Upregulation of ULBPs, which is one of the ligands for NK cell activating receptor NKG2D, was observed in the co-treatment of ferumoxytol mediated ferroptosis and NK cells. Additionally, HMGB1 and PD-L1 expression of cancer cells were observed in the treatment of ferroptosis + NK cells. Finally, in vivo therapeutic efficacy of ferumoxytol mediated ferroptosis and NK cell therapy was observed with significant tumor volume regression in a prostate cancer mice model. These results suggest that the NK cells’ function can be enhanced with ferumoxytol mediated ferroptosis.https://doi.org/10.1186/s12951-022-01635-yNK cellsFerroptosisCancer therapyNanomedicineProstate cancer |
| spellingShingle | Kwang-Soo Kim Bongseo Choi Hyunjun Choi Min Jun Ko Dong-Hwan Kim Dong-Hyun Kim Enhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer Journal of Nanobiotechnology NK cells Ferroptosis Cancer therapy Nanomedicine Prostate cancer |
| title | Enhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer |
| title_full | Enhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer |
| title_fullStr | Enhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer |
| title_full_unstemmed | Enhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer |
| title_short | Enhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer |
| title_sort | enhanced natural killer cell anti tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer |
| topic | NK cells Ferroptosis Cancer therapy Nanomedicine Prostate cancer |
| url | https://doi.org/10.1186/s12951-022-01635-y |
| work_keys_str_mv | AT kwangsookim enhancednaturalkillercellantitumoractivitywithnanoparticlesmediatedferroptosisandpotentialtherapeuticapplicationinprostatecancer AT bongseochoi enhancednaturalkillercellantitumoractivitywithnanoparticlesmediatedferroptosisandpotentialtherapeuticapplicationinprostatecancer AT hyunjunchoi enhancednaturalkillercellantitumoractivitywithnanoparticlesmediatedferroptosisandpotentialtherapeuticapplicationinprostatecancer AT minjunko enhancednaturalkillercellantitumoractivitywithnanoparticlesmediatedferroptosisandpotentialtherapeuticapplicationinprostatecancer AT donghwankim enhancednaturalkillercellantitumoractivitywithnanoparticlesmediatedferroptosisandpotentialtherapeuticapplicationinprostatecancer AT donghyunkim enhancednaturalkillercellantitumoractivitywithnanoparticlesmediatedferroptosisandpotentialtherapeuticapplicationinprostatecancer |