Impacting the Remedial Potential of Nano Delivery-Based Flavonoids for Breast Cancer Treatment
Breast cancer persists as a diffuse source of cancer despite persistent detection and treatment. Flavonoids, a type of polyphenol, appear to be a productive option in the treatment of breast cancer, because of their capacity to regulate the tumor related functions of class of compounds. Plant polyph...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/17/5163 |
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| author | Rakesh K. Sindhu Rishu Verma Twinkle Salgotra Md. Habibur Rahman Muddaser Shah Rokeya Akter Waheed Murad Sidra Mubin Parveen Bibi Safaa Qusti Eida M. Alshammari Gaber El-Saber Batiha Michał Tomczyk Hayder M. Al-kuraishy |
| author_facet | Rakesh K. Sindhu Rishu Verma Twinkle Salgotra Md. Habibur Rahman Muddaser Shah Rokeya Akter Waheed Murad Sidra Mubin Parveen Bibi Safaa Qusti Eida M. Alshammari Gaber El-Saber Batiha Michał Tomczyk Hayder M. Al-kuraishy |
| author_sort | Rakesh K. Sindhu |
| collection | DOAJ |
| description | Breast cancer persists as a diffuse source of cancer despite persistent detection and treatment. Flavonoids, a type of polyphenol, appear to be a productive option in the treatment of breast cancer, because of their capacity to regulate the tumor related functions of class of compounds. Plant polyphenols are flavonoids that appear to exhibit properties which are beneficial for breast cancer therapy. Numerous epidemiologic studies have been performed on the dynamic effect of plant polyphenols in the prevention of breast cancer. There are also subclasses of flavonoids that have antioxidant and anticarcinogenic activity. These can regulate the scavenging activity of reactive oxygen species (ROS) which help in cell cycle arrest and suppress the uncontrolled division of cancer cells. Numerous studies have also been performed at the population level, one of which reported a connection between cancer risk and intake of dietary flavonoids. Breast cancer appears to show intertumoral heterogeneity with estrogen receptor positive and negative cells. This review describes breast cancer, its various factors, and the function of flavonoids in the prevention and treatment of breast cancer, namely, how flavonoids and their subtypes are used in treatment. This review proposes that cancer risk can be reduced, and that cancer can be even cured by improving dietary intake. A large number of studies also suggested that the intake of fruit and vegetables is associated with reduced breast cancer and paper also includes the role and the use of nanodelivery of flavonoids in the healing of breast cancer. In addition, the therapeutic potential of orally administered phyto-bioactive compounds (PBCs) is narrowed because of poor stability and oral bioavailability of compounds in the gastrointestinal tract (GIT), and solubility also affects bioavailability. In recent years, creative nanotechnology-based approaches have been advised to enhance the activity of PBCs. Nanotechnology also offers the potential to become aware of disease at earlier stages, such as the detection of hidden or unconcealed metastasis colonies in patients diagnosed with lung, colon, prostate, ovarian, and breast cancer. However, nanoformulation-related effects and safety must not be overlooked. This review gives a brief discussion of nanoformulations and the effect of nanotechnology on herbal drugs. |
| first_indexed | 2024-03-10T08:07:00Z |
| format | Article |
| id | doaj.art-8e57f7beb30e429087e83bc429f8a462 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T08:07:00Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8e57f7beb30e429087e83bc429f8a4622023-11-22T11:00:00ZengMDPI AGMolecules1420-30492021-08-012617516310.3390/molecules26175163Impacting the Remedial Potential of Nano Delivery-Based Flavonoids for Breast Cancer TreatmentRakesh K. Sindhu0Rishu Verma1Twinkle Salgotra2Md. Habibur Rahman3Muddaser Shah4Rokeya Akter5Waheed Murad6Sidra Mubin7Parveen Bibi8Safaa Qusti9Eida M. Alshammari10Gaber El-Saber Batiha11Michał Tomczyk12Hayder M. Al-kuraishy13Chitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaChitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaChitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaDepartment of Pharmacy, Southeast University, Banani, Dhaka 1213, BangladeshDepartment of Botany, Abdul Wali Khan University Mardan, Mardan 23200, PakistanDepartment of Global Medical Science, Wonju College of Medicine, Yonsei University, Gangwon, Wonju 26426, KoreaDepartment of Botany, Abdul Wali Khan University Mardan, Mardan 23200, PakistanDepartment of Botany, Hazara University Mansehra, Mansehra 21310, PakistanDepartment of Botany, Abdul Wali Khan University Mardan, Mardan 23200, PakistanBiochemistry Department, Faculty of Science, King Abdul Aziz University, Jeddah 22230, Saudi ArabiaDepartment of Chemistry, College of Sciences, University of Ha’il, Ha’il 55211, Saudi ArabiaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Al Beheira, EgyptDepartment of Pharmacognosy, Medical University of Białystok, ul. Mickiewicza 2a, 15-230 Białystok, PolandDepartment of Clinical Pharmacology and Medicine, College of Medicine, Al Mustanysiriyia University, Baghdad 10011, IraqBreast cancer persists as a diffuse source of cancer despite persistent detection and treatment. Flavonoids, a type of polyphenol, appear to be a productive option in the treatment of breast cancer, because of their capacity to regulate the tumor related functions of class of compounds. Plant polyphenols are flavonoids that appear to exhibit properties which are beneficial for breast cancer therapy. Numerous epidemiologic studies have been performed on the dynamic effect of plant polyphenols in the prevention of breast cancer. There are also subclasses of flavonoids that have antioxidant and anticarcinogenic activity. These can regulate the scavenging activity of reactive oxygen species (ROS) which help in cell cycle arrest and suppress the uncontrolled division of cancer cells. Numerous studies have also been performed at the population level, one of which reported a connection between cancer risk and intake of dietary flavonoids. Breast cancer appears to show intertumoral heterogeneity with estrogen receptor positive and negative cells. This review describes breast cancer, its various factors, and the function of flavonoids in the prevention and treatment of breast cancer, namely, how flavonoids and their subtypes are used in treatment. This review proposes that cancer risk can be reduced, and that cancer can be even cured by improving dietary intake. A large number of studies also suggested that the intake of fruit and vegetables is associated with reduced breast cancer and paper also includes the role and the use of nanodelivery of flavonoids in the healing of breast cancer. In addition, the therapeutic potential of orally administered phyto-bioactive compounds (PBCs) is narrowed because of poor stability and oral bioavailability of compounds in the gastrointestinal tract (GIT), and solubility also affects bioavailability. In recent years, creative nanotechnology-based approaches have been advised to enhance the activity of PBCs. Nanotechnology also offers the potential to become aware of disease at earlier stages, such as the detection of hidden or unconcealed metastasis colonies in patients diagnosed with lung, colon, prostate, ovarian, and breast cancer. However, nanoformulation-related effects and safety must not be overlooked. This review gives a brief discussion of nanoformulations and the effect of nanotechnology on herbal drugs.https://www.mdpi.com/1420-3049/26/17/5163flavonoidsnanoparticlesbreast cancerdrug delivery systemcancer therapeuticsanticancer |
| spellingShingle | Rakesh K. Sindhu Rishu Verma Twinkle Salgotra Md. Habibur Rahman Muddaser Shah Rokeya Akter Waheed Murad Sidra Mubin Parveen Bibi Safaa Qusti Eida M. Alshammari Gaber El-Saber Batiha Michał Tomczyk Hayder M. Al-kuraishy Impacting the Remedial Potential of Nano Delivery-Based Flavonoids for Breast Cancer Treatment Molecules flavonoids nanoparticles breast cancer drug delivery system cancer therapeutics anticancer |
| title | Impacting the Remedial Potential of Nano Delivery-Based Flavonoids for Breast Cancer Treatment |
| title_full | Impacting the Remedial Potential of Nano Delivery-Based Flavonoids for Breast Cancer Treatment |
| title_fullStr | Impacting the Remedial Potential of Nano Delivery-Based Flavonoids for Breast Cancer Treatment |
| title_full_unstemmed | Impacting the Remedial Potential of Nano Delivery-Based Flavonoids for Breast Cancer Treatment |
| title_short | Impacting the Remedial Potential of Nano Delivery-Based Flavonoids for Breast Cancer Treatment |
| title_sort | impacting the remedial potential of nano delivery based flavonoids for breast cancer treatment |
| topic | flavonoids nanoparticles breast cancer drug delivery system cancer therapeutics anticancer |
| url | https://www.mdpi.com/1420-3049/26/17/5163 |
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