Early-onset neonatal sepsis and the implementation of group B streptococcus prophylaxis in a Brazilian maternity hospital: a descriptive study
Objectives: To describe early-onset neonatal sepsis (EOS) epidemiology in a public maternity hospital in Brasilia, Brazil. Methods: We defined EOS as a positive blood culture result obtained from infants aged ≤72 hours of life plus treatment with antibiotic therapy for ≥5 days. Incidence was calcula...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867016305116 |
| _version_ | 1819171500124536832 |
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| author | Felipe Teixeira de Mello Freitas Gustavo Adolfo Sierra Romero |
| author_facet | Felipe Teixeira de Mello Freitas Gustavo Adolfo Sierra Romero |
| author_sort | Felipe Teixeira de Mello Freitas |
| collection | DOAJ |
| description | Objectives: To describe early-onset neonatal sepsis (EOS) epidemiology in a public maternity hospital in Brasilia, Brazil. Methods: We defined EOS as a positive blood culture result obtained from infants aged ≤72 hours of life plus treatment with antibiotic therapy for ≥5 days. Incidence was calculated based on the number of cases and total live births (LB). This is a descriptive study comparing the period of 2012–2013 with the period of 2014–September 2015, before and after implementation of antibiotic prophylaxis during labor for group B streptococcus (GBS) prevention, respectively. Results: Overall, 36 infants developed EOS among 21,219 LB (1.7 cases per 1000 LB) and 16 died (case fatality rate of 44%). From 2014, 305 vaginal-rectal swabs were collected from high-risk women and 74 (24%) turned out positive for GBS. After implementation of GBS prevention guidelines, no new cases of GBS were detected, and the EOS incidence was reduced from 1.9 (95% CI 1.3–2.8) to 1.3 (95% CI 0.7–2.3) cases per 1000 LB from 2012–2013 to 2014–September 2015 (p = 0.32). Conclusions: Although the reduction of EOS incidence was not significant, GBS colonization among pregnant women was high, no cases of neonatal GBS have occurred after implementation of prevention guidelines. Keywords: Neonatal sepsis, Group B streptococcal disease, Escherichia coli infection, Brazil |
| first_indexed | 2024-12-22T19:52:16Z |
| format | Article |
| id | doaj.art-8e5a6e45d4d74dd7af15e0e8715d6a7b |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-22T19:52:16Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-8e5a6e45d4d74dd7af15e0e8715d6a7b2022-12-21T18:14:30ZengElsevierBrazilian Journal of Infectious Diseases1413-86702017-01-012119297S1413-86702017000100092Early-onset neonatal sepsis and the implementation of group B streptococcus prophylaxis in a Brazilian maternity hospital: a descriptive studyFelipe Teixeira de Mello Freitas0Gustavo Adolfo Sierra Romero1Secretaria de Estado de Saúde do Distrito Federal, Hospital Materno Infantil de Brasília, Brasília, DF, Brazil; Universidade de Brasília, Núcleo de Medicina Tropical, Brasília, DF, Brazil; Corresponding author.Universidade de Brasília, Núcleo de Medicina Tropical, Brasília, DF, BrazilObjectives: To describe early-onset neonatal sepsis (EOS) epidemiology in a public maternity hospital in Brasilia, Brazil. Methods: We defined EOS as a positive blood culture result obtained from infants aged ≤72 hours of life plus treatment with antibiotic therapy for ≥5 days. Incidence was calculated based on the number of cases and total live births (LB). This is a descriptive study comparing the period of 2012–2013 with the period of 2014–September 2015, before and after implementation of antibiotic prophylaxis during labor for group B streptococcus (GBS) prevention, respectively. Results: Overall, 36 infants developed EOS among 21,219 LB (1.7 cases per 1000 LB) and 16 died (case fatality rate of 44%). From 2014, 305 vaginal-rectal swabs were collected from high-risk women and 74 (24%) turned out positive for GBS. After implementation of GBS prevention guidelines, no new cases of GBS were detected, and the EOS incidence was reduced from 1.9 (95% CI 1.3–2.8) to 1.3 (95% CI 0.7–2.3) cases per 1000 LB from 2012–2013 to 2014–September 2015 (p = 0.32). Conclusions: Although the reduction of EOS incidence was not significant, GBS colonization among pregnant women was high, no cases of neonatal GBS have occurred after implementation of prevention guidelines. Keywords: Neonatal sepsis, Group B streptococcal disease, Escherichia coli infection, Brazilhttp://www.sciencedirect.com/science/article/pii/S1413867016305116 |
| spellingShingle | Felipe Teixeira de Mello Freitas Gustavo Adolfo Sierra Romero Early-onset neonatal sepsis and the implementation of group B streptococcus prophylaxis in a Brazilian maternity hospital: a descriptive study Brazilian Journal of Infectious Diseases |
| title | Early-onset neonatal sepsis and the implementation of group B streptococcus prophylaxis in a Brazilian maternity hospital: a descriptive study |
| title_full | Early-onset neonatal sepsis and the implementation of group B streptococcus prophylaxis in a Brazilian maternity hospital: a descriptive study |
| title_fullStr | Early-onset neonatal sepsis and the implementation of group B streptococcus prophylaxis in a Brazilian maternity hospital: a descriptive study |
| title_full_unstemmed | Early-onset neonatal sepsis and the implementation of group B streptococcus prophylaxis in a Brazilian maternity hospital: a descriptive study |
| title_short | Early-onset neonatal sepsis and the implementation of group B streptococcus prophylaxis in a Brazilian maternity hospital: a descriptive study |
| title_sort | early onset neonatal sepsis and the implementation of group b streptococcus prophylaxis in a brazilian maternity hospital a descriptive study |
| url | http://www.sciencedirect.com/science/article/pii/S1413867016305116 |
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