Mouse Model of Small for Gestational Age Offspring with Catch-up Growth Failure and Dysregulated Glucose Metabolism in Adulthood
Background: We aimed to build mouse models of small for gestational age (SGA), recapitulating failure of catch-up growth and dysregulated metabolic outcomes in adulthood. Methods: Pregnant C57BL/6 mice were given a protein-restricted diet (PRD; 6% kcal from protein) during pregnancy without (model 1...
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| Format: | Article |
| Language: | English |
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Korean Society for the Study of Obesity
2022-03-01
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| Series: | Journal of Obesity & Metabolic Syndrome |
| Subjects: | |
| Online Access: | http://journaleditor.inforang.com/journal/view.html?doi=10.7570/jomes22013 |
| _version_ | 1818393634176761856 |
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| author | Hyeon Seok Moon Hanbin Kim Bohye Kim Min-Seon Kim Jae Hyun Kim Obin Kwon |
| author_facet | Hyeon Seok Moon Hanbin Kim Bohye Kim Min-Seon Kim Jae Hyun Kim Obin Kwon |
| author_sort | Hyeon Seok Moon |
| collection | DOAJ |
| description | Background: We aimed to build mouse models of small for gestational age (SGA), recapitulating failure of catch-up growth and dysregulated metabolic outcomes in adulthood. Methods: Pregnant C57BL/6 mice were given a protein-restricted diet (PRD; 6% kcal from protein) during pregnancy without (model 1) or with cross-fostering (model 2). Model 3 extended the PRD to the end of the lactation period. Model 4 changed to a 9% PRD without cross-fostering. Results: Model 1 yielded a reduced size of offspring with a poor survival rate. Model 2 improved survival but offspring showed early catch-up growth. Model 3 maintained a reduced size of offspring after weaning with a higher body mass index and blood glucose levels in adult stages. Model 4 increased the survival of the offspring while maintaining a reduced size and dysregulated glucose metabolism. Conclusion: Models 3 and 4 are suitable for studying SGA accompanying adulthood short stature and metabolic disorders. |
| first_indexed | 2024-12-14T05:48:26Z |
| format | Article |
| id | doaj.art-8e5d1cb906b443d1b1f3129a4276f8d1 |
| institution | Directory Open Access Journal |
| issn | 2508-6235 |
| language | English |
| last_indexed | 2024-12-14T05:48:26Z |
| publishDate | 2022-03-01 |
| publisher | Korean Society for the Study of Obesity |
| record_format | Article |
| series | Journal of Obesity & Metabolic Syndrome |
| spelling | doaj.art-8e5d1cb906b443d1b1f3129a4276f8d12022-12-21T23:14:48ZengKorean Society for the Study of ObesityJournal of Obesity & Metabolic Syndrome2508-62352022-03-01311818510.7570/jomes22013jomes22013Mouse Model of Small for Gestational Age Offspring with Catch-up Growth Failure and Dysregulated Glucose Metabolism in AdulthoodHyeon Seok Moon0Hanbin Kim1Bohye Kim2Min-Seon Kim3Jae Hyun Kim4Obin Kwon5Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, KoreaDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, KoreaDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Diabetes Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Pediatrics, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, KoreaBackground: We aimed to build mouse models of small for gestational age (SGA), recapitulating failure of catch-up growth and dysregulated metabolic outcomes in adulthood. Methods: Pregnant C57BL/6 mice were given a protein-restricted diet (PRD; 6% kcal from protein) during pregnancy without (model 1) or with cross-fostering (model 2). Model 3 extended the PRD to the end of the lactation period. Model 4 changed to a 9% PRD without cross-fostering. Results: Model 1 yielded a reduced size of offspring with a poor survival rate. Model 2 improved survival but offspring showed early catch-up growth. Model 3 maintained a reduced size of offspring after weaning with a higher body mass index and blood glucose levels in adult stages. Model 4 increased the survival of the offspring while maintaining a reduced size and dysregulated glucose metabolism. Conclusion: Models 3 and 4 are suitable for studying SGA accompanying adulthood short stature and metabolic disorders.http://journaleditor.inforang.com/journal/view.html?doi=10.7570/jomes22013small for gestational agegrowth failureglucose metabolism disordersobesity |
| spellingShingle | Hyeon Seok Moon Hanbin Kim Bohye Kim Min-Seon Kim Jae Hyun Kim Obin Kwon Mouse Model of Small for Gestational Age Offspring with Catch-up Growth Failure and Dysregulated Glucose Metabolism in Adulthood Journal of Obesity & Metabolic Syndrome small for gestational age growth failure glucose metabolism disorders obesity |
| title | Mouse Model of Small for Gestational Age Offspring with Catch-up Growth Failure and Dysregulated Glucose Metabolism in Adulthood |
| title_full | Mouse Model of Small for Gestational Age Offspring with Catch-up Growth Failure and Dysregulated Glucose Metabolism in Adulthood |
| title_fullStr | Mouse Model of Small for Gestational Age Offspring with Catch-up Growth Failure and Dysregulated Glucose Metabolism in Adulthood |
| title_full_unstemmed | Mouse Model of Small for Gestational Age Offspring with Catch-up Growth Failure and Dysregulated Glucose Metabolism in Adulthood |
| title_short | Mouse Model of Small for Gestational Age Offspring with Catch-up Growth Failure and Dysregulated Glucose Metabolism in Adulthood |
| title_sort | mouse model of small for gestational age offspring with catch up growth failure and dysregulated glucose metabolism in adulthood |
| topic | small for gestational age growth failure glucose metabolism disorders obesity |
| url | http://journaleditor.inforang.com/journal/view.html?doi=10.7570/jomes22013 |
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