A Probiotic <i>Lactobacillus gasseri</i> Alleviates <i>Escherichia coli</i>-Induced Cognitive Impairment and Depression in Mice by Regulating IL-1β Expression and Gut Microbiota
Excessive expression of interleukin (IL)-1β in the brain causes depression and cognitive dysfunction. Herein, we investigated the effect of <i>Lactobacillus gasseri</i> NK109, which suppressed IL-1β expression in activated macrophages, on <i>Escherichia coli</i> K1-induced co...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/11/3441 |
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| author | Soo-Won Yun Jeon-Kyung Kim Kyung-Eon Lee Young Joon Oh Hak-Jong Choi Myung Joo Han Dong-Hyun Kim |
| author_facet | Soo-Won Yun Jeon-Kyung Kim Kyung-Eon Lee Young Joon Oh Hak-Jong Choi Myung Joo Han Dong-Hyun Kim |
| author_sort | Soo-Won Yun |
| collection | DOAJ |
| description | Excessive expression of interleukin (IL)-1β in the brain causes depression and cognitive dysfunction. Herein, we investigated the effect of <i>Lactobacillus gasseri</i> NK109, which suppressed IL-1β expression in activated macrophages, on <i>Escherichia coli</i> K1-induced cognitive impairment and depression in mice. Germ-free and specific pathogen-free mice with neuropsychiatric disorders were prepared by oral gavage of K1. NK109 alleviated K1-induced cognition-impaired and depressive behaviors, decreased the expression of IL-1β and populations of NF-κB<sup>+</sup>/Iba1<sup>+</sup> and IL-1R<sup>+</sup> cells, and increased the K1-suppressed population of BDNF<sup>+</sup>/NeuN<sup>+</sup> cells in the hippocampus. However, its effects were partially attenuated by celiac vagotomy. NK109 treatment mitigated K1-induced colitis and gut dysbiosis. Tyndallized NK109, even if lysed, alleviated cognitive impairment and depression. In conclusion, NK109 alleviated neuropsychiatric disorders and colitis by modulating IL-1β expression, gut microbiota, and vagus nerve-mediated gut–brain signaling. |
| first_indexed | 2024-03-10T14:59:00Z |
| format | Article |
| id | doaj.art-8e5d37c9f9ab421bb4acfb121f268aaa |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T14:59:00Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-8e5d37c9f9ab421bb4acfb121f268aaa2023-11-20T20:23:32ZengMDPI AGNutrients2072-66432020-11-011211344110.3390/nu12113441A Probiotic <i>Lactobacillus gasseri</i> Alleviates <i>Escherichia coli</i>-Induced Cognitive Impairment and Depression in Mice by Regulating IL-1β Expression and Gut MicrobiotaSoo-Won Yun0Jeon-Kyung Kim1Kyung-Eon Lee2Young Joon Oh3Hak-Jong Choi4Myung Joo Han5Dong-Hyun Kim6Department of Food and Nutrition, Kyung Hee University, Seoul 02447, KoreaNeurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02447, KoreaNeurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02447, KoreaDivision of Research and Development, World Institute of Kimchi, Gwangju 61755, KoreaDivision of Research and Development, World Institute of Kimchi, Gwangju 61755, KoreaDepartment of Food and Nutrition, Kyung Hee University, Seoul 02447, KoreaNeurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02447, KoreaExcessive expression of interleukin (IL)-1β in the brain causes depression and cognitive dysfunction. Herein, we investigated the effect of <i>Lactobacillus gasseri</i> NK109, which suppressed IL-1β expression in activated macrophages, on <i>Escherichia coli</i> K1-induced cognitive impairment and depression in mice. Germ-free and specific pathogen-free mice with neuropsychiatric disorders were prepared by oral gavage of K1. NK109 alleviated K1-induced cognition-impaired and depressive behaviors, decreased the expression of IL-1β and populations of NF-κB<sup>+</sup>/Iba1<sup>+</sup> and IL-1R<sup>+</sup> cells, and increased the K1-suppressed population of BDNF<sup>+</sup>/NeuN<sup>+</sup> cells in the hippocampus. However, its effects were partially attenuated by celiac vagotomy. NK109 treatment mitigated K1-induced colitis and gut dysbiosis. Tyndallized NK109, even if lysed, alleviated cognitive impairment and depression. In conclusion, NK109 alleviated neuropsychiatric disorders and colitis by modulating IL-1β expression, gut microbiota, and vagus nerve-mediated gut–brain signaling.https://www.mdpi.com/2072-6643/12/11/3441<i>Lactobacillus gasseri</i>cognition impairmentdepressionIL-1βgut microbiota |
| spellingShingle | Soo-Won Yun Jeon-Kyung Kim Kyung-Eon Lee Young Joon Oh Hak-Jong Choi Myung Joo Han Dong-Hyun Kim A Probiotic <i>Lactobacillus gasseri</i> Alleviates <i>Escherichia coli</i>-Induced Cognitive Impairment and Depression in Mice by Regulating IL-1β Expression and Gut Microbiota Nutrients <i>Lactobacillus gasseri</i> cognition impairment depression IL-1β gut microbiota |
| title | A Probiotic <i>Lactobacillus gasseri</i> Alleviates <i>Escherichia coli</i>-Induced Cognitive Impairment and Depression in Mice by Regulating IL-1β Expression and Gut Microbiota |
| title_full | A Probiotic <i>Lactobacillus gasseri</i> Alleviates <i>Escherichia coli</i>-Induced Cognitive Impairment and Depression in Mice by Regulating IL-1β Expression and Gut Microbiota |
| title_fullStr | A Probiotic <i>Lactobacillus gasseri</i> Alleviates <i>Escherichia coli</i>-Induced Cognitive Impairment and Depression in Mice by Regulating IL-1β Expression and Gut Microbiota |
| title_full_unstemmed | A Probiotic <i>Lactobacillus gasseri</i> Alleviates <i>Escherichia coli</i>-Induced Cognitive Impairment and Depression in Mice by Regulating IL-1β Expression and Gut Microbiota |
| title_short | A Probiotic <i>Lactobacillus gasseri</i> Alleviates <i>Escherichia coli</i>-Induced Cognitive Impairment and Depression in Mice by Regulating IL-1β Expression and Gut Microbiota |
| title_sort | probiotic i lactobacillus gasseri i alleviates i escherichia coli i induced cognitive impairment and depression in mice by regulating il 1β expression and gut microbiota |
| topic | <i>Lactobacillus gasseri</i> cognition impairment depression IL-1β gut microbiota |
| url | https://www.mdpi.com/2072-6643/12/11/3441 |
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