Effect of maternal hypertensive disorders during pregnancy on offspring's early childhood body weight: A population-based cohort study
Objective: The prevalence of hypertensive disorder during pregnancy (HDP) and childhood obesity is increasing worldwide. HDP or obesity in mothers can increase the risk of overweight/obesity (OWOB) in their children. Few longitudinal studies have examined the associations of maternal body weight wit...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455922002054 |
| _version_ | 1811275402523443200 |
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| author | Yuan-Der Huang Yun-Ru Luo Meng-Chih Lee Chih-Jung Yeh |
| author_facet | Yuan-Der Huang Yun-Ru Luo Meng-Chih Lee Chih-Jung Yeh |
| author_sort | Yuan-Der Huang |
| collection | DOAJ |
| description | Objective: The prevalence of hypertensive disorder during pregnancy (HDP) and childhood obesity is increasing worldwide. HDP or obesity in mothers can increase the risk of overweight/obesity (OWOB) in their children. Few longitudinal studies have examined the associations of maternal body weight with the growth and risk factors for overweight in infants born to mothers with HDP. This study examined the risk factors for childhood OWOB through the age of 66 months in children born to mothers with HDP. Materials and methods: In total, 24,200 pairs of mothers and their children were selected from the Taiwan Birth Cohort Study. The children's body weights were classified and analyzed to determine infant growth at birth and at the ages of 12, 24, 36, and 66 months. Multiple logistic regression analyses with different model settings were performed to identify the factors affecting growth and childhood OWOB in the children of mothers with HDP. Results: The average birth weight of children was lower in the HDP group than in the non-HDP group. The catch-up phenomenon began at the age of 18 months. The incidence of OWOB was higher in the children in the HDP group than in those in the non-HDP group from the age of 24 months and increased with the children's age. At every age point, maternal overweight before pregnancy was the main risk factor for childhood OWOB, and this effect increased with the children's age (odds ratio [OR]: 1.83 at 66 months). The effect of excessive maternal gestational weight gain on childhood OWOB was significant (OR: 1.26–1.44 for various age points). Conclusion: Maternal overweight is the main risk factor for OWOB in children born to mothers with HDP. After adjusting for related confounders, we determined that HDP did not exert a significant effect on the risk of childhood OWOB. |
| first_indexed | 2024-04-12T23:38:20Z |
| format | Article |
| id | doaj.art-8e5dac4e95364a078298b0bfea9198ca |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-04-12T23:38:20Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-8e5dac4e95364a078298b0bfea9198ca2022-12-22T03:12:04ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592022-09-01615761767Effect of maternal hypertensive disorders during pregnancy on offspring's early childhood body weight: A population-based cohort studyYuan-Der Huang0Yun-Ru Luo1Meng-Chih Lee2Chih-Jung Yeh3Department of Public Health, Chung-Shan Medical University, Taichung, Taiwan; Department of Obstetrics and Gynecology, Chia-Yi Hospital, Ministry of Health and Welfare, Chia-Yi, TaiwanDepartment of Public Health, Chung-Shan Medical University, Taichung, TaiwanDepartment of Family Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan; College of Management, Chaoyang University of Technology, Taichung, Taiwan; Corresponding author. Department of Family Medicine, Taichung Hospital, Ministry of Health and Welfare, No. 199, Sec. 1, Sanmin Rd., West Dist., Taichung City 403, Taiwan.Department of Public Health, Chung-Shan Medical University, Taichung, Taiwan; Corresponding author. Department of Public Health, Chung-Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd., South Dist., Taichung City 402, Taiwan.Objective: The prevalence of hypertensive disorder during pregnancy (HDP) and childhood obesity is increasing worldwide. HDP or obesity in mothers can increase the risk of overweight/obesity (OWOB) in their children. Few longitudinal studies have examined the associations of maternal body weight with the growth and risk factors for overweight in infants born to mothers with HDP. This study examined the risk factors for childhood OWOB through the age of 66 months in children born to mothers with HDP. Materials and methods: In total, 24,200 pairs of mothers and their children were selected from the Taiwan Birth Cohort Study. The children's body weights were classified and analyzed to determine infant growth at birth and at the ages of 12, 24, 36, and 66 months. Multiple logistic regression analyses with different model settings were performed to identify the factors affecting growth and childhood OWOB in the children of mothers with HDP. Results: The average birth weight of children was lower in the HDP group than in the non-HDP group. The catch-up phenomenon began at the age of 18 months. The incidence of OWOB was higher in the children in the HDP group than in those in the non-HDP group from the age of 24 months and increased with the children's age. At every age point, maternal overweight before pregnancy was the main risk factor for childhood OWOB, and this effect increased with the children's age (odds ratio [OR]: 1.83 at 66 months). The effect of excessive maternal gestational weight gain on childhood OWOB was significant (OR: 1.26–1.44 for various age points). Conclusion: Maternal overweight is the main risk factor for OWOB in children born to mothers with HDP. After adjusting for related confounders, we determined that HDP did not exert a significant effect on the risk of childhood OWOB.http://www.sciencedirect.com/science/article/pii/S1028455922002054Birth cohortChildhood overweightGrowthHypertensive disorder during pregnancy |
| spellingShingle | Yuan-Der Huang Yun-Ru Luo Meng-Chih Lee Chih-Jung Yeh Effect of maternal hypertensive disorders during pregnancy on offspring's early childhood body weight: A population-based cohort study Taiwanese Journal of Obstetrics & Gynecology Birth cohort Childhood overweight Growth Hypertensive disorder during pregnancy |
| title | Effect of maternal hypertensive disorders during pregnancy on offspring's early childhood body weight: A population-based cohort study |
| title_full | Effect of maternal hypertensive disorders during pregnancy on offspring's early childhood body weight: A population-based cohort study |
| title_fullStr | Effect of maternal hypertensive disorders during pregnancy on offspring's early childhood body weight: A population-based cohort study |
| title_full_unstemmed | Effect of maternal hypertensive disorders during pregnancy on offspring's early childhood body weight: A population-based cohort study |
| title_short | Effect of maternal hypertensive disorders during pregnancy on offspring's early childhood body weight: A population-based cohort study |
| title_sort | effect of maternal hypertensive disorders during pregnancy on offspring s early childhood body weight a population based cohort study |
| topic | Birth cohort Childhood overweight Growth Hypertensive disorder during pregnancy |
| url | http://www.sciencedirect.com/science/article/pii/S1028455922002054 |
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