Review of possible mechanisms of radiotherapy resistance in cervical cancer
Radiotherapy is one of the main treatments for cervical cancer. Early cervical cancer is usually considered postoperative radiotherapy alone. Radiotherapy combined with cisplatin is the standard treatment for locally advanced cervical cancer (LACC), but sometimes the disease will relapse within a sh...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1164985/full |
| _version_ | 1797737297581441024 |
|---|---|
| author | Hanqun Zhang Hanqun Zhang Xiaohu Wang Xiaohu Wang Xiaohu Wang Xiaohu Wang Yan Ma Qiuning Zhang Qiuning Zhang Qiuning Zhang Ruifeng Liu Ruifeng Liu Ruifeng Liu Hongtao Luo Hongtao Luo Hongtao Luo Zi Wang |
| author_facet | Hanqun Zhang Hanqun Zhang Xiaohu Wang Xiaohu Wang Xiaohu Wang Xiaohu Wang Yan Ma Qiuning Zhang Qiuning Zhang Qiuning Zhang Ruifeng Liu Ruifeng Liu Ruifeng Liu Hongtao Luo Hongtao Luo Hongtao Luo Zi Wang |
| author_sort | Hanqun Zhang |
| collection | DOAJ |
| description | Radiotherapy is one of the main treatments for cervical cancer. Early cervical cancer is usually considered postoperative radiotherapy alone. Radiotherapy combined with cisplatin is the standard treatment for locally advanced cervical cancer (LACC), but sometimes the disease will relapse within a short time after the end of treatment. Tumor recurrence is usually related to the inherent radiation resistance of the tumor, mainly involving cell proliferation, apoptosis, DNA repair, tumor microenvironment, tumor metabolism, and stem cells. In the past few decades, the mechanism of radiotherapy resistance of cervical cancer has been extensively studied, but due to its complex process, the specific mechanism of radiotherapy resistance of cervical cancer is still not fully understood. In this review, we discuss the current status of radiotherapy resistance in cervical cancer and the possible mechanisms of radiotherapy resistance, and provide favorable therapeutic targets for improving radiotherapy sensitivity. In conclusion, this article describes the importance of understanding the pathway and target of radioresistance for cervical cancer to promote the development of effective radiotherapy sensitizers. |
| first_indexed | 2024-03-12T13:26:39Z |
| format | Article |
| id | doaj.art-8e5e4a43a767422093be15d2df370347 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T13:26:39Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8e5e4a43a767422093be15d2df3703472023-08-25T06:10:57ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-08-011310.3389/fonc.2023.11649851164985Review of possible mechanisms of radiotherapy resistance in cervical cancerHanqun Zhang0Hanqun Zhang1Xiaohu Wang2Xiaohu Wang3Xiaohu Wang4Xiaohu Wang5Yan Ma6Qiuning Zhang7Qiuning Zhang8Qiuning Zhang9Ruifeng Liu10Ruifeng Liu11Ruifeng Liu12Hongtao Luo13Hongtao Luo14Hongtao Luo15Zi Wang16The First School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaDepartment of Oncology, Guizhou Provincial People's Hospital, Guizhou, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou, ChinaLanzhou Heavy Ion Hospital, Lanzhou, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou, ChinaLanzhou Heavy Ion Hospital, Lanzhou, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou, ChinaLanzhou Heavy Ion Hospital, Lanzhou, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou, ChinaLanzhou Heavy Ion Hospital, Lanzhou, ChinaDepartment of Oncology, Guizhou Provincial People's Hospital, Guizhou, ChinaRadiotherapy is one of the main treatments for cervical cancer. Early cervical cancer is usually considered postoperative radiotherapy alone. Radiotherapy combined with cisplatin is the standard treatment for locally advanced cervical cancer (LACC), but sometimes the disease will relapse within a short time after the end of treatment. Tumor recurrence is usually related to the inherent radiation resistance of the tumor, mainly involving cell proliferation, apoptosis, DNA repair, tumor microenvironment, tumor metabolism, and stem cells. In the past few decades, the mechanism of radiotherapy resistance of cervical cancer has been extensively studied, but due to its complex process, the specific mechanism of radiotherapy resistance of cervical cancer is still not fully understood. In this review, we discuss the current status of radiotherapy resistance in cervical cancer and the possible mechanisms of radiotherapy resistance, and provide favorable therapeutic targets for improving radiotherapy sensitivity. In conclusion, this article describes the importance of understanding the pathway and target of radioresistance for cervical cancer to promote the development of effective radiotherapy sensitizers.https://www.frontiersin.org/articles/10.3389/fonc.2023.1164985/fullcervical cancerradiotherapyradiotherapy resistancemechanismradiotherapy sensitivity |
| spellingShingle | Hanqun Zhang Hanqun Zhang Xiaohu Wang Xiaohu Wang Xiaohu Wang Xiaohu Wang Yan Ma Qiuning Zhang Qiuning Zhang Qiuning Zhang Ruifeng Liu Ruifeng Liu Ruifeng Liu Hongtao Luo Hongtao Luo Hongtao Luo Zi Wang Review of possible mechanisms of radiotherapy resistance in cervical cancer Frontiers in Oncology cervical cancer radiotherapy radiotherapy resistance mechanism radiotherapy sensitivity |
| title | Review of possible mechanisms of radiotherapy resistance in cervical cancer |
| title_full | Review of possible mechanisms of radiotherapy resistance in cervical cancer |
| title_fullStr | Review of possible mechanisms of radiotherapy resistance in cervical cancer |
| title_full_unstemmed | Review of possible mechanisms of radiotherapy resistance in cervical cancer |
| title_short | Review of possible mechanisms of radiotherapy resistance in cervical cancer |
| title_sort | review of possible mechanisms of radiotherapy resistance in cervical cancer |
| topic | cervical cancer radiotherapy radiotherapy resistance mechanism radiotherapy sensitivity |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1164985/full |
| work_keys_str_mv | AT hanqunzhang reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT hanqunzhang reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT xiaohuwang reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT xiaohuwang reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT xiaohuwang reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT xiaohuwang reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT yanma reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT qiuningzhang reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT qiuningzhang reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT qiuningzhang reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT ruifengliu reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT ruifengliu reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT ruifengliu reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT hongtaoluo reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT hongtaoluo reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT hongtaoluo reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer AT ziwang reviewofpossiblemechanismsofradiotherapyresistanceincervicalcancer |