| Summary: | Background: Network biology approaches have emerged as a promising tool to study disease mechanisms and explain comorbidities. Network biology approaches can be applied to integrate the complex neural networks that can help in understanding the molecular mechanisms of neurodevelopmental disorders and hence provide an insight into the diagnosis and treatment of these disorders. Aim: To identify priority genes involved in ADHD through multiple system biology approach and its subsequent treatment through molecular interaction studies. Methodology: In the present study, genes related to the neurodevelopmental disorders associated with ADHD were identified. STRING plugin on cytoscape was used to construct network and identify the hub genes. Further, expression, mutational, and regulatory analysis of the identified priority genes was done to evaluate its expression in brain. Computational drug designing approaches were further applied to identify the natural drug that can target the identified priority gene for the treatment of neurodevelopmental disorders. Objective: The present study is an attempt to identify the priority genes and thereby explain the molecular mechanism of neurodevelopmental disorders using computational network biology approaches in integration with other in-silico tools. Result: Our study concludes that GRIN2B can be a potential target in the mechanism of different neurodevelopmental disorders. The docking of GRIN2B receptor with neuroprotectant phytochemicals revealed that Asiatic acid, a naturally occurring pentacyclic triterpenoid, extracted from Centella asiatica can be used as a potential phytocompound for the treatment of Neurodevelopmental Disorders. Conclusion: Asiatic acid can be used as a therapeutic agent against GRIN2B receptor for treatment of ADHD.
|
|---|