Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction

Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction

Summary: MCL-1 is a high-priority target due to its dominant role in the pathogenesis and chemoresistance of cancer, yet clinical trials of MCL-1 inhibitors are revealing toxic side effects. MCL-1 biology is complex, extending beyond apoptotic regulation and confounded by its multiple isoforms, its...

Full description

Bibliographic Details
Main Authors: Utsarga Adhikary, Joao A. Paulo, Marina Godes, Shrabasti Roychoudhury, Michelle S. Prew, Yael Ben-Nun, Ellen W. Yu, Amit Budhraja, Joseph T. Opferman, Dipanjan Chowdhury, Steven P. Gygi, Loren D. Walensky
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723011889

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723011889

Similar Items